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';Arctic Sky' tells of a young climate activist who discovers her own courage in the frozen depths of a Russian prison. ';Palimpsest' is set on a bionic (living)space station that launches explorers into the farthest reaches of Time and Space. In ';The Room on the Roof' an ancient culture meets modern mysteries with unexpected results. Our non-fiction title piece, ';Utopias of the Third Kind,' is a first look at actual utopias that are responding to our looming dystopian nightmare. ';Hunger' is a short story that finds both understanding and forgiveness for humankind's original sin. Our Outspoken Interview and a bibliography round out this new collection.
Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electron microscopy & encapsulation efficiency studies. These studies favorably revealed that the mean particle diameter of optimized formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical morphology. The optimized formulation demonstrated favorable in vitro prolonged release characteristics with zero order, diffusion and erosion mechanisms. Nanoparticles also showed excellent stability. Hence, the designed delivery system can be fine tuned on the depending clinical applications.
Younguncle arrives with his family at the gloomy, mysterious Hotel Pine-Away and soon discovers that their mountain holiday is going to be anything but peaceful. As he chats with monkeys and debates the true nature of reality with an offbeat sect of the Quantum Banana spiritualists, the fate of the picturesque little valley hangs in the balance.
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