Books by Zakarya El-Khayat

Acute lymphocytic leukemia (ALL) is a malignant disorder common among children. Apoptosis or programmed cell death is greatly involved in the mechanism of cancer development as well as drug resistance to cancer and it is the primary mechanism through which most chemotherapeutic agents induce tumor cell death. Total leukocytic count, hemoglobin, platelet count and Bone marrow blast count were used for follow up of patients. CD95 % and Bcl-2 concentration used as a new markers. It was found that both CD95 % and Bcl-2 concentration are useful diagnostic markers that may help not only in diagnosis but also in follow up of ALL cases. However, further studies are still needed involving larger number of patients and comparing values at diagnosis with values after completing the whole treatment course. It's also recommended to give Zn supplement to children with ALL in order to achieve rapid and permanent recovery.

Hepatitis infection is a major cause of chronic liver disease which infects more than 170 million persons worldwide, often leading to cirrhosis, hepatic failure and hepatocellular carcinoma. D-galactosamine-induced experimental model system in rats recognized to be much like viral hepatitis in humans from both morphological and functional points of view. Food derived antioxidants have a strong potential for long-term use as chemopreventive agents in disease states involving oxidative stress, such as hepatitis and alcoholic liver diseases because they are safe. Tea and cocoa are food sources rich in phenolic compounds and have several biological activities, such as the ability to scavenge superoxide and hydroxyl radicals, reduce lipid peroxyl radicals and inhibit lipid peroxidation . This study aimed to investigate the protective effect of some polyphenolic compounds, heavily present in green tea, black tea and cocoa, against liver injury and to know the potent effect of each in protecting the liver.