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Razrabotka protezow dlq zamescheniq porazhennyh klapanow serdca i sosudow qwlqetsq aktual'nym naprawleniem razwitiq serdechno-sosudistoj hirurgii. Dlq protezow, nahodqschihsq w postoqnnom kontakte s krow'ü i podwerzhennyh wysokomu risku tromboza, naibolee wazhnym swojstwom qwlqetsq gemosowmestimost'. Biologicheskie protezy imeüt nekotorye preimuschestwa pered sinteticheskimi analogami ¿ udowletworitel'nye gemodinamicheskie parametry, tromborezistentnost', ustojchiwost' k infekcii. Odnako analiz otdalennyh rezul'tatow primeneniq sosudistyh bioprotezow swidetel'stwuet, chto w strukture oslozhnenij preobladaüt trombozy. Dlq klapanow serdca i zaplat dlq intrakardial'noj i angioplastiki problema trombozow i tromboämbolij ne stol'ko suschestwenna, no, tem ne menee, dannye protezy nuzhdaütsq w powyshenii gemosowmestimosti. Takim obrazom, na rezul'taty operacij okazywaet wliqnie kachestwo bioprotezow, kotoroe wo mnogom zawisit ot sposoba konserwacii i posleduüschej modifikacii biomateriala. Dannaq rabota poswqschena izucheniü wliqniq nowyh konserwantow klassa äpoxisoedinenij i razlichnyh antikoagulqntow na gemosowmestimost' kardiowaskulqrnyh bioprotezow.
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