Books in the Advanced Biotechnology series

Provides a comprehensive treatment of the underlying concepts and the practical applications in metabolic engineering.

This book not only introduces the reader to the necessary tools to understand microbiome but also discusses many relevant areas of current research and applications of microbiome engineering, ranging from human diseases to husbandry, food and beverage applications.

The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries.

A comprehensive overview of the various aspects of systems biology, giving an introduction to specific branches and highlighting current state-of-the-art approaches to cell factory engineering and the improvement of human health.

A comprehensive overview of the topic, highlighting recent developments, ongoing research trends and future directions. Experts from Europe, Asia and the US cover five core areas of imminent importance to the food, feed, pharmaceutical and water treatment industries in terms of sustainable and innovative processing and production.

A review of the interdisciplinary field of synthetic biology, from genome design to spatialEngineering.Written by an international panel of experts, Synthetic Biology draws from various areas of research in biology and engineering and explores the current applications to provide an authoritative overview of this burgeoning field. The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy.Filled with the most recent research, compelling discussions, and unique perspectives, Synthetic Biology offers an important resource for understanding how this new branch of science can improve on applications for industry or biological research.Advanced BiotechnologyBiotechnology is a broad, interdisciplinary field of science, combining biological sciences and relevant engineering disciplines, that is becoming increasingly important as it benefits the environment and society as a whole. Recent years have seen substantial advances in all areas of biotechnology, resulting in the emergence of brand new fields. To reflect this progress, Sang-Yup Lee (KAIST, South Korea), Jens Nielsen (Chalmers University, Sweden), and Gregory Stephanopoulos (MIT, USA) have joined forces as the editors of a new Wiley-VCH book series. Advanced Biotechnology will cover all pertinent aspects of the field and each volume will be prepared by eminent scientists who are experts on the topic in question.

Part of the "Advanced Biotechnology" series, this volume covers all important aspects of cell culture engineering as applied to the production of recombinant proteins for therapeutic use, from molecular biology to bioprocess engineering. With a focus on mammalian and animal cells, the book describes the challenges in cell line development and cell engineering, while providing an overview of synthetic and systems biology approaches applied to cell culture engineering. In addition, the authors elaborate the use of CHO cells as common cell line for protein production and discuss current perspectives in production processes, including cell culture media, batch, fedΓÇôbatch and perfusion processes, as well as process analytical technology, quality by design and scale down models.