Books in the Advances in Experimental Medic series

The latest developments in the area of microbial immunity are explored and explained in this timely volume, including new conceptual frameworks for the processing and presentation of peptides and nonpeptide antigens from microbes to T cells. Such experimental models have been instrumental in defining some of the pathways for generating protective immune responses against microbes. Other topics covered include: DAP 12, CD4+, Th1 and Th2 Cells, HIV infection, fusion, and tropism, and vaccine development.

Basic Properties of the Actin Molecule and Actin-Based Microfilament Systems.- Vibrational Modes of G-Actin.- Combining Electron Microscopy and X-Ray Crystallography Data to Study the Structure of F-Actin and its Implications for Thin-Filament Regulation in Muscle.- Evidence for an F-Actin Like Conformation in the Actin: DNase I Complex.- Actin-Bound Nucleotide/Divalent Cation Interactions.- Influence of the High Affinity Divalent Cation on Actin Tryptophan Fluorescence.- C-Terminus on Actin: Spectroscopic and Immunochemical Examination of its Role in Actinomycin Interactions.- Actin Polymerization: Regulation by Divalent Metal Ion and Nucleotide Binding, ATP Hydrolysis and Binding of Myosin.- Actin-Associated Proteins and Control of Filament-Based Assembly-Disassembly.- Structural Requirements of Tropomyosin for Binding to Filamentous Actin.- Actin-Gelsolin Interaction.- Actin Regulation and Surface Catalysis.- Caldesmon: Possible Functions in Microfilament Reorganization During Mitosis and Cell Transformation.- Cytoskeleton, Motile Structures and Macromolecular Crowding.- Cellular Functions of the Microfilament System.- Actin Filament Dynamics in Cell Motility.- Changes in Adhesion Plaque Protein Levels Regulate Cell Motility and Tumorigenicity.- Induction of Collagen Synthesis in Response to Adhesion and TGF? is Dependent on the Actin-Containing Cytoskeleton.- Gelsolin Expression in Normal Human Keratinocytes is a Function of Induced Differentiation.- Actin Filaments and the Spatial Positioning of mRNA.- Redistribution of p52(PAI-l) mRNA to the Cytoskeletal Framework Accompanies Increased p52(PAI-l) Expression in Cytochalasin D-Stimulated Rat Kidney Cells.- Brush Border Myosin I Has a Calmodulin/Phosphatidylserine Switch and Tail Actin-Binding.- Control of p52(PAI-l) Gene Expression in Normal and Transformed Rat Kidney Cells: Relationship Between p52(PAI-l) Induction and Actin Cytoarchitecture.- Contributors

Section I: Controlled Fusion: Soon! (E. Teller). Comments on the Feasibility of Achieving Scientific Breakeven with a Plasma Focus Machine (J.S. Brzosko et al.). SelfColliding Beams as an Alternative Fusion System for DHe3 Reactors (N. Rostoker, M. Binderbauer). Target Physics for Inertial Fusion Energy (J.M. MartinezVal et al.). Spherical Pinch Research: Historical Background, Achievements, and Projections (F. Giammanco et al.). Section II: Perspectives of Advanced Confinement Programs (B. Coppi). Present Status of FieldReversed Configurations (J. Slough). Ignition Physics and the Ignitor Project (F. Pegoraro). The Inertial Electrostatic Confinement Approach to Fusion Power (G.H. Miley). The D3He Dipole Fusion Reactor (M.E. Mauel). OpenEnded Magnetic Confinement Systems for Fusion (R.F. Post, D.D. Ryutov). Formation, Compression, and Acceleration of Magnetized Plasmas (J.H. Degnan). Prospects of Magnetic Electrostatic Plasma Confinement (T.J. Dolan). Analysis of the Fusion Breakeven Conditions for DT Plasmas of Prescribed Temperature Evolution (E. Panarella). Section III: Progress in Inertial Fusion Research (C. Yamanaka). HeavyIon Driven Inertial Fusion Energy (R.O. Bangerter, T.J. Fessenden). XRay Driven Implosions on the Nova Laser (J.D. Kilkenny et al.). Present Status and Future Prospects of Laser Fusion Research at Osaka (C. Yamanaka). Magnetized Target Fusion: An Overview of the Concept (R.C. Kirkpatrick, M.A. Sweeney). Thermonuclear Fusion in a Staged Pinch (H.U. Rahman et al.). Novel Staged ZPinch Concept as a Super Radiant XRay Source for ICF (V.M. Bystritskii et al.). Section IV: Fusion, the Competition, and the Prospects for Alternative Fusion Concepts (L.J. Perkins et al.). Ideas for Future RFP Experiments (J.A. Phillips et al.). Dense ZPinches for Fusion (D. Scudder, J. Shlachter). Assessment of FieldReversedConfiguration Stability (R.E. Siemon). MuonCatalyzed Fusion in 1996 (S.E. Jones). Experimental Investigation of the Muon Catalyzed Fusion in Mixtures of Hydrogen Isotopes (V.M. Bystritsky). Magnetoelectric Toroidal Confinement (J.R. Roth). Ball Lightning: What Nature is Trying to Tell the Fusion Community (J.R. Roth). Fusion Implications of FreeFloating Plasmak(R) Magnetoplasmoids (P.M. Koloc). Section V: Alternate Fusion Concepts (N. Rostoker). Inertial Fusion Driven by Intense Cluster Ion Beams (C. Deutsch). Inertial Fusion Energy: An Approach to Low Maintenance and Cost of Electricity, and the Role of the National Ignition Facility Testing the Target Physics (B.G. Logan). Magnetized Target Fusion: An Ultrahigh Energy Approach in an Unexplored Parameter Space (R.C. Kirkpatrick et al.). Section VI: Concluding Remarks (E. Panarella). Section VII: Report of the Evaluators (E.C. Creutz et al.). Index.

Preservation of Moduli of Continuity for BersteinType Operators (J.A. Adell, J. de la Cal). Lp-Korovkin Type Inequalities for Positive Linear Operators (G.A. Anastassiou). On Some ShiftInvariate Integral Operators, Multivariate Case (G.A. Anastassiou, H.H. Gonska). Multivariate Probabalistic Wavelet Approximation (G. Anastassiou et al.). Probabalistic Approach to the Rounding Problem with Applications to Fair Representation (B. Athanasopoulos). Limit Theorums for Random Multinomial Forms (A. Basalykas). Multivariate Boolean Trapezoidal Rules (G. Baszenski, F.J. Delvos). Convergence Results for an Extension of the Fourier Transform (C. Belingeri, P.E. Ricci). The Action Constants (B.L. Chalmers, B. Shekhtman). Bivariate Probability Distributions Similar to Exponential (B. Dimitrov et al.). Probability, Waiting Time Results for Pattern and Frequency Quotas in the Same Inverse Sampling Problem Via the Dirichlet (M. Ebneshahrashoob, M. Sobel). 25 additional articles. Index.

Scalar Fields in Particle Physics and Cosmology; S. Rudaz. The Quark Mixing Matrix and CP Violation; C. Jarlskog. Pinning Down the Standard Model; F. Dydak. Issues in B Physics; M.V. Danilov. The Search for the Top Quark at the Tevatron; P.L. Tipton. Detection of Dark Matter and Solar Neutrinos; M. Spiro. Recent Developments in Tracking Detectors; D.H. Saxon. Experimental Challenges at Future Hadron Colliders; J. Siegrist. Technical Challenges of the LHC/SSC Colliders; D.A. Edwards. Index.

Femto-second Probing of Photoinduced Refractive Index Charges in Semiconductor; H.M. Van Driel, E.C. Fox. Tunneling of Electrons and Holes in Asymmetries Double Quantum Wells; J. Shah, et al. Ultrashort Excitation in Semiconductors; W.E. Bon. Contact-Free Characterization of Electronic and Optoelectronic Devices with Ultrashort Laser Pulses; J. Kuhl. Vibrational Relaxation Studied with Light; A. Lagendijk. Relaxation of Frenkeltype Rotational and Vibrational Excitons in Diatomic Molecular Crystals; E. Goovaertz. Quantum Transient Transport; C. Jacoboni, F. Rossi. Study of Irreversible Processes in Condensed Matter by Nonlinear Time and Space Resolved Techniques; Chr. Flytzanis. Index.

Overview: Big Bang in the Laboratory; H.H. Gutbrod, J. Rafelski. Physics of Relativistic Nuclear Collisions; I. Otterlund. Towards the LHC; P. Giubellino. Hot Hadronic Matter: Fireball Spectra; U. Heinz, et al. Quark Matter in Equilibrium; F. Karsch. Towards Dynamical Theoretical Description: Cascade Models and Particle Production; J. Cugnon. Relativistic Hydrodynamics and Flavor Flow; L. Csernai, et al. Quark-Gluon Plasma Formation in UltraRelativistic Heavy Ion Collisions; K. Geiger. Diagnostic Methods and Recent Results: A Pedestrian's Guide to Particle Interferometry; W.A. Zajc. Strangeness in Ultrarelativistic NucleusNucleus Collisions; E. Quercigh. On the Trail of Quark-Gluon Plasma; J. Rafelski. Epilogue: The Quark-Gluon Plasma; P.A. Carruthers. 20 additional articles. Index.

Chaotic Dynamics: Theory: Complexity, Control and Data Representation: Complexity and Unpredictable Scaling of Hierarchical Structures; R. Badii. Fractals, Multifractals, and Analyticity of Normal Forms: Multifractal Coding Measures in Dynamics; G. Mantica. Integrability, Painlevé Property, and Singularity Analysis: Note on a Complex Eckhaus Equation; M.F. Jorgensen, et al.. Statistical Physics, Celestial Mechanics, and Cosmology: Phase Transitions Within the Fully Developed Regime; R. Kluiving. Chaotic Dynamics: Practice: Controlling Dynamical Systems: Feedback Control of Chaotic Systems; . Romeiras et al.. Semiconductors, Superconductors, Lasers, and Electronic Circuits: Chaotic Dynamics in Practice; E. Del Rio, et al . Biology, Chemistry, Atmospheric, and Magnetospheric Dynamics: Irregular Bursting in Model Neurones; J. Hyde. Hamiltonian Dynamics, Dissipative Dynamics, and Normal Forms. 30 additional articles. Index.

2D Gravity and Non-Perturbative Effects: Diffusion Equation, Continuum Limit and Universality in 2D Quantum Gravity; O. Alvarez, et al. On Triangles and Squares; C. Bachas. Non-Perturbative Effects in 2D Gravity and Matrix Modles; F. David. Integrable Models of 2D Quantum Gravity; P. Di Francesco, et al. Topological Strings and Loop Equations; R. Dijkgraaf, et al. The Two Matrix Model; M.R. Douglas. Action Principle and Large Order Behavior of Non-Perturbative Gravity; P. Ginsparg, et al. D = 1 Strings and String Field Theory: Matrix Models, String Field Theory and Topology; T. Banks. Multipoint Correlation Functions in One-Dimensional String Theory; D. Boulativ. The Penner Model and D = 1 String Theory J. Distler, et al. Non-Perturbative String Theory; D.J. Gross. Bosonic Strings and String Field Theories in One-Dimensional Target Space; V. Kazakov. Liouville Theory andD 1: Random Surfaces in Dimensions Larger than One; J. Ambjorn. On Gauge Invariances in Stochastic Quantization; L. Baulieu. The Quantum Group Structure of Quantum Gravity in Two Dimensions; J.L. Gervais. Notes on Quantum Liouville Theory and Quantum Gravity; N. Seiberg. 8 additional articles. Index.

Opening Lecture.- The Champions of the Universe.- Theoretical Lectures.- Dark Matter.- Polarized Electroproduction and the Spin of the Quarks inside the Proton.- Quantum Chromodynamics of Hadron Jets.- Considerations on the Moduli Space of Calabi-Yau Manifolds.- Exotic Signatures from Supersymmetry.- Baby Universes and the Cosmological Constant Problem.- Recent Ideas on the Cosmological Constant Problem.- Review Lectures.- Quantum Strings and the Constants of Nature.- The LAA Project - Second Year of Activity.- Seminars on Specialized Topics.- A Crucial Test for QCD: The Time-like E.M. Form Factors of the Neutron.- Challenges to Quantum Chromodynamics: Anomalous Spin, Heavy Quark, and Nuclear Phenomena.- Prizes and Scholarships.- Participants.

Taylor-Couette Flow, Experiment and Theory: Evolution of Instrumentation for Taylor-Couette Flow; R.J. Donnelly. Phase Dynamics in the Taylor-Couette System; M. Wu, C.D. Andereck. Taylor-Couette Flow Systems with Broken Rotational Symmetry: End Circulation in Non-Axisymmetrical Flows; C. Normand et, al. Turbulence in Taylor-Couette and Plane Couette Flow: Numerical Simulation of Turbulent Taylor-Couette Flow; S. Hirschberg. Instabilities, Pattern Formation, and Turbulence in Model Equations: Double Eigenvalues and the Formation of Flow Patterns; R. Meyer-Spache. Extensions of Taylor-Couette Flow: Taylor Vortex Flow with Superimposed Radial Mass Flux; K. Buehler. Open Flows: Structure and Perturbation in Gortler Vortex Flow; P. Petitjeans, J.E. Wesfreid. Appendix: A Guide to Literature Related to the Taylor-Couette Problem; R. Tagg. 24 additional articles. Index.

The Development of the Vascular System: Embryonic Development of Blood Vessels; F. Dieterlen-Liévre, L. Pardanaud. Regulation of Embryonic Blood Vessel; H. Drexler et al.. Biology of Endothelial Cells and Angiogenesis: Basic Fibroblast Growth Factor and Endothelial Cells; M. Presta, et al. Role of Integrinss in Endothelial Cell Function; E. Dejana, et al. Angiogenesis in Disease States: Angiogenesis and Neoplastic Transformation; P.M. Gullino. Tumor Induced Angiogenesis; J.L. Ambrus, et al. Promoters and Inhibitors of Angiogenesis: Brain Tumor Angiogenesis; C. Guerin, et al. Therapeutic Potential of Promoters and Inhibitors of Angiogenesis: On Promoter of Angiogenesis and Therapeutic Potential; P.M. Gullino. Methodology: Assays for Angiogenic Factors; J.B. Weiss. 23 additional articles. Index.

Evaluation of Flat versus Complex Terrain Models in Estimating Pollutant Transport and Deposition in Complex Terrain; M.W. Yambert, et al. Small Particle Deposition in Air Quality Modeling; R. Kapahi. Accounting for Wet Deposition in Incinerator Risk Assessments; A.A. Campbell, et al. Accounting for Dry Deposition in Incinerator Risk Assessments; C.C. Travis, et al. Gas-Particle Distribution and Atmospheric Deposition of Semivolatile Organic COmpounds; T.F. Bidleman. An Overview of Food Chain Impacts from Municipal Waste Combustion; H.A. Hattemer-Frey, et al. Current Studies on Human Exposure to Chemicals with Emphasis on the Plant Route; S. Paterson, et al. Airto-Leaf Transfer of Organic Vapors to Plants; E. Bacci, et al. Uptake of Organic Contaminants by Plants; C. Mc Farlane. Uncertainties in Estimating Chemical Degradation and Accumulation in the Environment; S.T. Washburn, et al. The Food Chain as a Source of Human Exposure from Municipal Waste Combustion: An Uncertainty Analysis; G. Belcher, et al. Assessing Multiple Pathway Exposures: Variability, Uncertainty, and Ignorance; T.E. McKone. Uncertainty Analysis: An Essential Component of Risk Assessment and Risk Management; R. Tyler, et al. 3 additional articles. Index.

Some Problems in Limb Development.- The Molecular Basis of Limb Patterning: A Review.- Expression of the Msh-like Homeobox-containing Genes During Mouse Limb Development.- The Limb Deformity Gene Encodes Evolutionarily Highly Conserved Proteins.- The Role of Homeobox Genes in Amphibian Limb Development and Regeneration.- Homeobox-Containing Genes and Gap Junctional Communication in Pattern Formation During Chick Limb Development.- Functional Studies of Genes in the Limb.- Hox-7: Temporal Patterns of Expression in Normal and Limbless Chick Embryos.- Expression Profile of Two Homeobox Genes During Chicken Embryogenesis.- Characterisation of Three Zebrafish Genes Related to Hox-7.- A Comparison of the Expression Domains of the Murine Hox-4, RARs and CRABP Genes Suggest Possible Functional Relationships During Patterning of the Vertebrate Limb.- Retinoic Acid Nuclear Receptors.- The Role of Retinoic Acid and Cellular Retinoic Acid-Binding Protein in the Regenerating Amphibian Limb.- Retinoic Acid Treatment Alters the Pattern of Retinoic Acid Receptor Beta Expression in the Embryonic Chick Limb.- Expression Pattern of an RXR Nuclear Receptor Gene in the Chick Embryo.- Retinoic Acid and Limb Pattern Formation in Cell Culture.- Growth Factors Produced by the Polarising Zone - a Complement to the Retinoic Acid System.- Biochemical and Molecular Aspects of Retinoid Action in Limb Pattern Formation.- Position-Dependent Properties of Limb Cells.- Retinoic Acid and Limb Patterning and Morphogenesis.- Does Retinoic Acid Organise a Limb or Induce a ZPA?.- Retinoic Acid Effects on Experimental Chick Wing Buds: Patterns of Cell Death and Skeletogenesis.- A Comparison of Reaction Diffusion and Mechanochemical Models for Limb Development.- The Pathway of Polarising Activity from Hensen's Node to the Wing Bud in the Chick Embryo.- Extracellular Matrix in Early Limb Development.- Molecular Heterogeneity of Chondroitin Sulphate in the Developing Chick Limb.- Special Properties of the AER/Mesenchyme Interface in the Chick Wing Bud: Analysis of ECM Molecules and Integrin Receptors.- Physical Forces and Pattern Formation in Limb Development.- Extracellular Material Organization and Long Tendon Formation in the Chick Leg Autopodium. In Vivo and In Vitro Study.- Hyaluronan-Cell Interactions in Limb Development.- The Role of the Transforming Growth Factor-ß (TGF-ß) Family, Extracelluiar Matrix and Gap Junctional Communication in Limb Cartilage Differentiation.- Vascular Involvement in Cartilage and Bone Development.- Patterning of Connective Tissues in the Regenerating Amphibian Limb.- The Interdigital Spaces of the Chick Leg Bud as a Model for Analysing Limb Morphogenesis and Cell Differentiation.- A "Packaging Model" of Limb Development.- The Somite-Muscle Relationship in the Avian Embryo.- Observations Concerning the Control of Directed Myogenic Cell Migration.- Extracellular Matrix and Muscle Formation.- Control of Muscle Morphogenesis and Endplate Pattern in Limb Muscles of Avian Chimeras.- Review of the Extracellular Matrix in Relation to Limb Development.- Evolution of Connective and Skeletal Tissues.- Developmental Approaches to the Problem of Transformation of Limb Structure in Evolution.- New Palaeontological Contributions to Limb Ontogeny and Phylogeny.- The Fin-Limb Transformation: Palaeontological and Embryological Evidence.- The Development of the Teleost Fin and Implications for our Understanding of Tetrapod Limb Evolution.- Phylogenetically Ancient Pattern in Ontogenesis of Limb Muscles.- Mutation and Limb Evolution.- Insights into Limb Development and Pattern Formation from Studies of the Limbless and Talpid2 Chick Mutants.- Proximal Elements in the Vertebrate Limb: Evolutionary and Developmental Origin of the Pectoral Girdle.- Evolutionary Transformation of Limb Pattern: Heterochrony and Secondary Fusion.- Plasticity in Skeletal Development: Knee-Joint Morphology in Fibula-Deficient Chick Embryos.- The Implications of "The Bauplan" f

Characterization of Gene and Protein Structure.- Biosynthesis and Assembly of the Factor VIII-von Willebrand Factor Complex.- Factor IX: Gene Structure and Protein Synthesis.- Antithrombin III Genetics, Structure and Function.- Interactions Between the Functional Domains of Antithrombin III.- Protein C: Gene Structure and Protein Synthesis.- Structural and Functional Properties of Protein C.- Molecular Defects Affecting Hemostasis.- Molecular Defects in Hemophilia A.- Molecular Defects in Hemophilia B.- Molecular Defects in Human Antithrombin III Deficiency.- The Biologic Impact of Hereditary Defects that Cause Thrombosis.- Protein Production by Recombinant Technology.- Factors Limiting Expression of Secreted Proteins in Mammalian Cells.- Synthesis of Biologically Active Vitamin K-Dependent Coagulation Factors.- The Expression of Therapeutic Proteins in Transgenic Animals.- Clinical use of Proteins Produced by Recombinant Technology.- The Use of Animal Models to Evaluate Proteins Produced by Recombinant Technology.- Experiences with Recombinant Factor VIIa in Hemophiliacs.- Clinical Trials of Factor VIII Produced by Recombinant Technology.- Clinical Trials of Recombinant Factor VIII.- Concluding Overview.- The Impact of Recombinant Technologies in Understanding Plasma Proteins Important for Hemostasis and Thrombosis.- Contributors.

Free Radicals/Ischemia Reperfusion Injury: Basal Relief of EDRF under Conditions of Oxidant Stress; N. Marczin, et al. Invasion and Neoplasia: Interaction of Malaria-Infected Cells with the Vascular Wall; G. Senaldi, et al. EndothelialTumor Cell Interactions In vitro and In vivo; R. Giavazzi, et al. Altered Vascular Reactivity: Altered Vascular Reactivity in Coronary Artery Disease; J. Zanzinger, E. Bassenge. Isoforms of Nitric Oxide Synthase and the Nitric Oxide-Cycle GMP Signal Transduction System; F. Murad, et al. Inflamation/Atherosclerosis: Proinflammatory Role of Leukocyte Adhesion Molecules; J.M. Harlan, et al. Circulating Endothelial Adhesion Molecules; J.L. Gordon, et al. Organ Transplantation/Rejection: Experimental Cell Transplantation and Gene Therapy Techniques in the Treatment of Liver Disease; A.A. Demetriou, et al. 6 additional articles. Index.

Physiology and Metabolism: Genetic Influences on Urinary Calcium Excretion (R.P. Holmes et al.). Oxalate Metabolism and Transport: Vectorial Oxalate Transport across a Monolayer of Renal Epithelial Cells (H. Koul et al.). Physicochemistry, Promoters and Inhibitors: Crystal Growth and Nucleation Rates for Calcium Oxalate in 92% Fresh Urine in a Continuous Crystalliser (J.P. Kavanagh et al.). Crystallization and Proteins: Possible Role of Stone Matrix in Calcium Oxalate Stone Formation (S. Yamaguchi et al.). Stone Composition, Matrix and Membranes: Role of Organic Matrix in Formation and Growth of Calcium Oxalate Urinary Stones (S.R. Khan, R.L. Hackett). Risk Factors and Diet: Urinary Silicate in Calculous Patients (W.C. Thomas). Epidemiology and Infection: Urinary Enzymes (C.H. van Aswegen et al.). ESWL and Lithotropsy: Ultrasound Velocity-A Measure of Stone Strength? (N.P. Cohen et al.). Investigation, Medical and Surgery Management: A New Therapeutic Agent for Cystinuria (T. Koide et al.). 276 additional articles. Index.

Dendritic Cells; J.M. Austyn. The Multiple Accessory Cell Concept; M. Van Rooijen. Sythetic Peptides and the Role of T-Helper Cell Determinants; M.J. Francis. Carriers for Peptides; M.J. Francis. Co-Entrapment of T-Cell and B-Cell Peptides in Liposomes Overcomes Genetic Restriction in Mice and Induces Immunological Memory; G. Gregoriadis, et al. Preparation and Characterization of Stable Liposomal Hepatitis B Vaccine; D. Diminsky, et al. Initiation of Immune Response with ISCOM; B. Morein, et al. Nanoparticles as Potent Aduvants for Vaccines; J. Kreuter. Optimization of Carriers and Adjuvants; A. Snidjders, et al. Immunotargeting as an Adjuvant Independent Subunit Vaccine Design Option; D.L. Skea, B.H. Barber. BCG Vaccine; M.J. Groves, et al. Significance of Virulence Factors and ImmunoEvasion for the Design of Gene-Deleted Herpesvirus Marker Vaccines; S. Kit. Eradication of Sylvatic Rabies Using a Live Recombinant Vaccinia-vRabies Vaccine; M.P. Kieny, et al. 7 additional articles. Index.

Section One - Regulation Of Cell Growth And Development.- The Role of Growth Hormone and Prolactin in Beta-Cell Growth and Regeneration.- The Insulin-Like Growth Factor Family of Peptides, Binding Proteins and Receptors: Their Potential Role in Tissue Regeneration.- The Effects of IGF-I and IGF-II on Cell Growth and Differentiation in the Central Nervous System.- Growth Factor Expression in Normal and Diabetic Rats During Peripheral Nerve Regeneration through Silicone Tubes.- Oncogenes and Cell Growth.- Interferon - A Candidate Mediator of Cell Growth.- Section Two - Models for the Study of Cell Regeneration.- Islet Beta-Cell Regeneration and Reg Genes.- Factors Regulating Islet Regeneration in the Post-Insulinoma NEDH Rat.- Regeneration of Pancreatic Endocrine Cells in Interferon Gamma Transgenic Mice.- Trophic Stimulation of the Ductular-Islet Cell Axis: A New Approach to the Treatment of Diabetes.- Section Three - Induction of Cell Growth and Mechanisms.- Expression of Insulin-Like Growth Factors (IGFs) and Their Binding Proteins (IGF BPs) During Pancreatic Development in Rat, and Modulation of IGF Actions on Rat Islet DNA Synthesis by IGF BPs.- The Partial Isolation and Characterization of Ilotropin, A Novel Islet-Specific Growth Factor.- Expression of Growth Factors in a Pancreatic Islet Regeneration Model.- Role of p21ras in Hormone Signalling and Cell Growth Transformation.- Phosphoinositides and Cell Growth.- The Physiological STOP Pathway: Target Regulation of Axonal Growth.- Cell Calcium Regulation of Myosin I - A Motor for Membrane Movement.- Section Four - Pathogenic and Therapeutic Ramifications.- Amylin Expression in the Pancreatic Beta-Cell.- Studies of Composite Grafts of Fetal Pancreas (FP) and Fetal Liver (FL) in the Streptozotocin-Induced Diabetic Rat.- Contributors.

Cell to Organ: Electromechanical Activation.- 1 Regulation of Intracellular Calcium in Cardiac Muscle.- 2 Neuromodulation of Calcium Current by Extracellular ATP in Isolated Ventricular Myocytes.- 3 Intracellular Calcium and Myocardial Function during Ischemia.- 4 Intracellular Signaling in Vascular Smooth Muscle.- 5 Myocardial Energetics.- 6 Mechanisms of Endocardial Endothelium Modulation of Myocardial Performance.- 7 Calcium Kinetic and Mechanical Regulation of the Cardiac Muscle.- 8 Cellular Responses to Electrical Stimulation: A Study Using a Model of the Ventricular Cardiac Action Potential.- 9 Excitation-Contraction Coupling and Contractile Protein Function in Failing and Nonfailing Human Myocardium.- Mechanics and Microcirculation.- 10 Estimation of Myocardial Mechanical Properties with Dynamic Transverse Stiffness.- 11 Intramyocardial Mechanical States: Vessel-Interstitium-Muscle Interface.- 12 Myocardial Mechanics and Coronary Flow Dynamics.- 13 Modeling of Coronary Capillary Flow.- Microstructure: Mechanics and Microcirculation.- 14 Models for Coronary Pressure-Flow Relationships.- 15In VivoMyocardial Microcirculation: Evaluation with a Whole-Body X-Ray CT Method.- 16 Endocardial Coronary Microcirculation of the Beating Heart.- 17 Distribution and Control of Coronary Microvascular Resistance.- 18 Theoretical Analysis of Coronary Blood Flow and Tissue Oxygen Pressure-Control.- Microcirculation and Metabolic Transport.- 19 Adenosine Coronary Vasodilation during Hypoxia Depends on Adrenergic Receptor Activation.- 20 Chaos in Cardiac Signals.- 21 Intramyocardial Fluid Transport Effects on Coronary Flow and Left Ventricular Mechanics.- 22 Metabolic Protection of Post-Ischemic Phosphorylation Potential and Ventricular Performance.- 23 Metabolic and Mechanical Control of the Microcirculation.- Remodeling of Muscle and Vessels.- 24 Asymmetrical Changes in Ventricular Wall Mass by Asynchronous Electrical Activation of the Heart.- 25 Ventricular Remodeling after Myocardial Infarction.- 26 Arterial Remodelling after Percutaneous Transluminal Balloon Angioplasty.- 27 Structural and Functional Remodeling of Poststenotic Arteries in the Rat.- 28 Myocardial Collagen and Its Functional Role.- Cardiac Function and Circulation.- 29 Ventricular-Arterial Interaction: Cardiac Effects of Mean versus Pulsatile Arterial Load.- 30 The Veins and Ventricular Preload.- 31 Why Smaller Animals Have Higher Heart Rates.- 32 Feedback Effects in Heart-Arterial System Interaction.- Integrated Analysis.- 33 The Relationship between Altered Load and Impaired Diastolic Function in Conscious Dogs with Pacing Induced Heart Failure.- 34 Interactions: The Integrated Functioning of Heart and Lungs.- 35 Carotid-Cardiac Interaction: Heart Rate Variability during the Unblocking of the Carotid Artery.- 36 Right and Left Ventricle Interaction and Remodeling in Congenital Heart Disease.- 37 Macroscopic Three-Dimensional Motion Patterns of the Left Ventricle.- 38 Cardiovascular Flow Velocity Measurements by 2D Doppler Imaging for Assessment of Vascular Function.- The Editors.- Contributors.

Chemistry. Tetrahydrobiopterin Dependent Hydroxylases. Tetrahydrobiopterin Regenerating Enzymes. Tetrahydrobiopterin Biosynthesis. Tetrahydrobiopterin Regulation. Tetrahydrobiopterin Deficiency. Nitric Oxide Synthase. Other Functions of Tetrahydrobiopterins. Molybdopterin Cofactors. Synthesis and Biological Evaluation of AntiFolates. Dihydrofolate Reductase. Thymidylate Synthase. Folylpolyglutamate Synthetase and Hydrolase. OneCarbon Metabolism. Folate Nutrition and Transport. 165 articles. Index.

Methods and Procedures for Preparing Resealed Erythrocytes: IHP Entrapment into Human Erythrocytes; A. Mosca, et al. Resealed Erythrocytes as a Tool for Basic Studies: ATP Monitoring in Human Red Blood Cells with Luciferase Introduced Intracellularly; V.M. Vitvitsky, et al. Resealed Erythrocytes as a Cellular Bioreactors: Acetaldehayde Oxidation by Aldehyde Dehydrogenase Loaded Erythrocytes; P. Ninfali, et al. Resealed Erythrocytes as Advanced Drug Delivery Systems: Erythrocytes as Carriers of New Anti-Opioid Prodrugs; S. Noel-Hocquet, et al. Site Specific Targeting of Resealed Erythrocytes: Erythrocytes as Carriers of Ricin A Chain; N. Chestier, et al. Human and Veterinary Studies Using Resealed Erythrocytes: Susceptibility of Carrier Erythrocytes to a Natural Hemolytic System; H.J. Kirch, et al. 36 additional articles. Index.

A Perspective of Resonant Tunneling; L.L. Chang. Materials and Band-Structure Effects: Epitaxial Growth of Atomically Smooth GaAs/AlxGa1xAs Interfaces for Resonant Tunneling; K. Ploog. MBE Growth of High Performance GaAs/GaAlAs and InGaAs/GaAlAs Double Barrier Quantum Well Structures for Resonant Tunneling Devices; H. Riechert, et al. Tunneling in Polytype InAs-AlSb-GaSb Heterostructures; K.F. Longenbach, et al. Scattering and Dynamic Effects: Scattering processes, Coherent and Incoherent Transport in Resonant Tunneling Structures; B. Vinter, et al. Quantum Coherence and Phase Randomization in Series Resistors; M. Büttiker. Charge Buildup, Intrinsic Bistability and Energy Relaxation in Resoant Tunneling Structures: High Pressure and Magnetic Field Studies; L. Eaves, et al. Multiple-Barrier and Low-Dimensional Systems: Miniband Transport and Resonant Tunneling in Superlattices; J.F. Palmier. Transport in Superlattices: Observation of Negative Differential Conductance by Field Induced Localization and Its Equivalence with the Esaki-Tsu Mechanism: Scattering Controlled Resonances in Superlattices; F. Capasso, et al. Device Structures: High-Frequency Oscillators Based on Resonant Tunneling; T.C.L.G> Sollner, et al. 39 additional articles. Index.

I. Intracellular Communications.- Tissue Specificity and Cell Death are Associated with Specific Alterations in Nuclear Matrix Proteins.- Mechanism of Growth Regulation in Androgen Responsive Cells.- The Impact of Androgen, Extracellular Matrix, and Stroma upon Proliferation and Differentiation of Benign and Malignant Prostate Epithelial Cells.- Therapeutic Approaches to Activating Programmed Cell Death of Androgen-Independent Prostatic Cancer Cells.- Cell Motility and Structural Harmonics in Prostate Cancer.- Panel Discussion.- II. Growth Factors - 1.- Studies of the Endocrine and Paracrine Effect of Tumor Produced Factors in Human Genitourinary Cancers.- Fibroblast Growth Factor: Implications in the Etiology of Benign Prostatic Hyperplasia.- Fibroblast-Mediated Human Epithelial Tumor Growth and Hormonal Responsiveness In Vivo.- Polyamine Requirement of Prostate Cancer Cell Proliferation.- Heparin-Binding (Fibroblast) Growth Factor/Receptor Gene Expression in the Prostate.- Characterization and Partial Purification of a Non - Heparin-Binding Prostate Growth Factor From Cancerous Human Prostate.- Panel Discussion.- Growth Factors - 2.- Transforming Growth Factor a: A Potential Autocrine Growth Regulator in Prostatic Carcinoma.- Prostatic Growth Factors (PrGFs) - From the Identification of Probasin to the Role of PrGFs.- Urogenital Sinus Derived Growth Inhibitory Factor.- Growth Factor Antagonists in Prostate Cancer: Suramin and Cytotoxic Polyamines as Potential Therapy.- Transforming Growth Factors in Human Prostate Cancer.- Gene Products as the Motivating Force in the Prostate Cell's Response to Androgens.- Panel Discussion.- III. Steroid Receptors.- Molecular Biology of Prostate - Specific Antigen.- Structure and Expression of the Androgen Receptor in Normal Tissues and in Prostate Carcinoma Cell Lines.- Structural Analysis and Gene Expression of TR2 Receptor and TR3 Receptor.- cDNA Cloning, Antibody Production and Immunohistochemical Localization of the Androgen Receptor.- New Approaches to Studies on the Androgen Receptor.- Specific Receptors for Vitamin D3 in Human Prostatic Carcinoma Cells.- Panel Discussion.- IV. Poster Presentations.- Role of Androgens and Extracellular Matrix in the Growth and Differentiation of Benign and Malignant Prostatic Epithelial Cells.- Tissue Specificity and Cell Death Are Associated with Specific Alterations in Nuclear Matrix Proteins.- ElTect of Transformation on Rat Prostatic Fibroblasts: Alterations In Extracellular Matrix and Cytoskeleton Gene Expression with Retention of Androgen Responsiveness and Androgen Receptor Expression.- A Potential Role for the MDR-1 Gene in the Development of Androgen-Independent Tumors.- Relevance of Low Androgen Levels and Adrenal Androgens in the Growth of Transplantable Human Prostatic Carcinomas.- Growth-Stimulating Effect of Growth Factor(s) from Androgen Independent Tumor Cells (CS 2-Cell) on Androgen Responsive Tumor Cells.- The Cellular Form of Human Prostatic Acid Phosphatase May Function as a Phosphotyrosyl Protein Phosphatase in Cells.- Expression of Prostate Antigen in LNCaP Cells in Culture.- Allelic Expression of the Mouse Ren-1 Genes in the Anterior Prostate (Coagulating Gland).- V. Dna Structure and Gene Expression.- Genomic Alterations in Prostatic Cancer.- Regulation of Gene Expression in the Prostate.- Androgen Regulation of HBGF I-(aFGF) and Characterization of the Androgen-Receptor mRNA in the Human Prostate Carcinoma Ceil Une - LNCaP/A-dep.- DNA Methylation, Differentiation and Cancer.- Evidence for tbe Involement of Genetic Differences and Mesenchymal Factors in the Progression of Oncogene - Induced Prostate Cancer in Reconstituted Mouse Prostate.- Differential Hybridization Analysis as a Tool to Study Prostatic Cancer Metastasis.- Molecular Biology of Androgen Acceptors in Prostatic Cancer Cells.- Panel Discussion.- Panel Discussion.- Panel Discussion.- Panel Discussion.- Panel Discussion.- Contributors.

Background on Semimagnetic Semiconductors.- Thermodynamics and Crystal Growth of Diluted Magnetic Semiconductors.- Band Structure and Theory of Magnetic Interactions in Diluted Magnetic Semiconductors.- Transport phenomena in Semimagnetic Semiconductors.- Experimental Studies of the d-d Exchange Interactions in Diluted Magnetic Semiconductors.- Bound Magnetic Polarons in Diluted Magnetic Semiconductors.- Magnetooptic Properties of Wide Gap II1?xMnxVI Semimagnetic Semiconductors.- II-Fe-VI Semimagnetic Semiconductors.- Semimagnetic IV-VI Compound Semiconductors.- Semimagnetic Semiconductor Superlattices.- Magnetism of Fe-Based Diluted Magnetic Semiconductors.