Books in the Advances in Experimental Medicine and Biology series

"Heart Failure: From Research to Clinical Practice" contains chapters that describe the current views on the biological mechanisms, clinical assessment, diagnosis and evidence-based treatments of the condition.

This book is a compendium of articles providing insights into a range of contemporary ideas concerning the core yet unsettled clinical issues.

This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology.This book also:Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic processProvides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopyIncludes insight into NCIs' role in supporting biomechanics in oncology researchDetails how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer

This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics.

This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017.

This book explains omics at the most basic level, including how this new concept can be properly utilized in molecular and systems biology research.

Pulmonary disorders significantly contribute to the current level of disease burden. This book highlights the issues involved with diagnosing and managing various pulmonary conditions such as chronic obstructive pulmonary disorders, respiratory tract infections, including those developing as a sequel of antibiotic treatment, and others.

This volume explores novel concepts of pericyte biology. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific diseases.

The book presents the latest developments in clinical medicine, particularly involved with pulmonary care and diseases.

The aim of this book is to present articles that are stimulating to read and inform readers with the most up-to-date clinical research. The articles incorporate the latest developments on a variety of topics in pulmonary medicine, therapy, and related mutlisystem disorders with varied manifestations. Emphasis is given to air quality and lung health, therapeutic management of airway reactivity and cough sensitivity linked to mucous clearance ability, ventilatory and cellular effects of hypoxia, influenza epidemics and persistently dismal vaccination coverage rate, disorders of mixed provenance and genetic background affecting lung parenchyma such as cystic fibrosis or Langerhans cell histiocytosis, and others. New diagnostic strategies and therapeutic management will hopefully serve to enhance the way patient care is delivered and thus clinical outcomes. Being a blend of medical research and practice the book addresses the needs of respiratory scientists and physicians, and allied health professionals.

This book gathers multidisciplinary articles that present advances of our understanding of diseases and the effective treatment of patients. The authors share recent clinical and experimental research findings, highlighting poorly understood areas with uncertain treatment outcomes, such as giant-cell bone tumors and their propensity to metastasize to the lungs; subterranean rehabilitation in pulmonary disorders; male reproductive hormone regulation during physical exercise in hyperbaric, hyperoxic environments, like underwater diving; and amelioration of cognitive decline owing to increased cerebral blood transit time after internal carotid artery stenting. Other topics include new concepts and innovations in the treatment of diabetes in pregnancy, and leg ulcers in chronic venous insufficiency, as well as molecular research on the toxic effects of oxidative stress, impaired cell autophagy, and experimental conditions resembling air pollution.Featuring the latest interdisciplinary advances in biomedicine, this book is a valuable resource for medical professionals, both academics and practitioners, and all allied health-care workers.

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine.

This book contains the refereed contributions from the 43rd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum.

This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing.

Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies.

The aim of the Protein Reviews is to serve as a publication vehicle for review articles that focus on crucial current vigorous aspects of protein structure, function, evolution and genetics. The volumes will appear online before they are published in a printed book. Articles are selected according to their importance to the understanding of biological systems, their relevance to the unravelling of issues associated with health and disease or their impact on scientific or technological advances and developments. The chapters in volume 18 are authored by experts in the field. They deal with aspects of structure and/or biological activity of selected proteins. The chapters review current research of the following topics: the Mechanism of channel gating and regulation of the activity of calcium-activated chloride channel ANO1, Structure and function of the two-component cytotoxins of Staphylococcus aureus, Membrane Fusion and Infection involving the influenza virus hemagglutinin, The impact of arrhythmogenic mutations through the structural determination of the L-type voltage-gated calcium channel, Discussion of some open questions pertaining to histone post-translational modifications and nucleosome organization in transcriptional regulation, Regulation of the extracellular SERPINA5 (protein C inhibitor) penetration through cellular membranes, Coding of Class I and II aminoacyl-tRNA synthetases, Nephrin phosphorylation in diabetes and chronic kidney injury, The structure-forming juncture in oxidative protein folding and the events in the ER, The polyspecificity of anti-lipid antibodies and its relevance to the development of autoimmunity. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.

This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017.

The companion title, Cell & Molecular Biology of Prostate Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to prostate cancer.

Following the Third Alcohol and Cancer Conference, this volume compiles the most up-to-date research on the role of alcohol consumption in carcinogenesis, from epidemiology to pathology metabolism and stem cells.

This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.

Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics.

Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies.

This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy.

Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions.This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature¿s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the sixth volume of a continuing series.

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease.

This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including Cathepsin D, galectins, iron, oxygen, Phospholipase D1, leptin, extracellular vesicles, and more.

Amy Zarzeczny The future of stem cell research and its clinical translation in Canada: Exploring questions of governance and policy options. Ali Mobasheri  Future cell and gene therapy for osteoarthritis (OA): potential for using mammalian protein production platforms, irradiated and transfected protein packaging cell lines for over-production of therapeutic proteins and growth factors Babak Arjmand Bagher Larijani Motahareh Sheikh Hosseini Moloud Payab Kambiz Gilany  Parisa Goodarzi Peyvand Parhizkar Roudsari Mobina Amanollahi Baharvand; Negin sadat Hoseini Mohammadi The Horizon of Gene Therapy in Modern Medicine:  Advances and Challenges. Neslihan Meric, Gulen Guney Esken, Fatih Kocabas Developments in Artificial Platelet and Erythroid Transfusion Products. Ali Golchin, Forough Shams, Farshid Karami  Advancing mesenchymal stem cell therapy with CRISPR/Cas9 for clinical trial studies. Tunc AKKOC Mesenchymal Stem Cells in Asthma.  Toka A. Ahmed, Sara M. Ahmed, Zaynab El-Gammal,Shaimaa Shouman, Ashrakat Ahmed, Ragaa Mansour, and Nagwa El-Badri Oocyte Aging: the Role of Cellular and Environmental Factors and Impact on Female Fertility. Esra Aydemir ├çoban, Didem Tecimel, Fikrettin ┼₧ahin, Ay┼ƒen Asl─▒ H─▒zl─▒ Deniz Targeting Cancer Metabolism and Cell Cycle by Plant-derived Compounds. Safa AYDIN, Derya SA─₧RA├ç, Fikrettin ┼₧AH─░N DIFFERENTIATION POTENTIAL OF MESENCHYMAL STEM CELLS INTO PANCREATIC ╬▓-CELLS. Ezgi Av┼ƒar Abdik, Ay┼ƒen Asl─▒ H─▒zl─▒ Deniz, H├╝seyin Abdik, Safa Ayd─▒n, Fikrettin ┼₧ahin, Pakize Neslihan Ta┼ƒl─▒ Zooming in across the Skin: A Macro-to-Molecular Panorama. 

In collaboration with the Breast Cancer Research Foundation (BCRF), this timely volume provides a comprehensive review on all areas of breast cancer survivorship research, highlighting research that is underway or in development.