Books in the Biological and Medical Physics, Biomedical Engineering series

In the third part, the particular importance of the technique in biotechnical applications is presented demonstrating the progress for miniaturized cell-free processes, for molecular biology and DNA-based diagnostics and sequencing as well as for the development of antibiotics and the evaluation of toxic effects in medicine and environment.

The book is designed primarily to address the needs of an academically inclined medical physicist who wishes to learn the technique, as well as experienced users of standard Monte Carlo codes who wish to gain insight into the underlying mathematics of Monte Carlo algorithms.

This book begins with the basic terms and definitions and takes a student, step by step, through all areas of medical physics. Students will find An Introduction to Medical Physics to be an indispensible resource in preparations for further graduate studies in the field.

This advanced study book provides the tools for understanding elementary processes in biology. It also covers many concepts in modern biophysics such as entropic forces, phase separation, proton and electron transfer and potentials of mean force.

This book highlights important techniques for cellular imaging and covers the basics and applications of electron tomography and related techniques.

This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidic mesophases, or living cells. The final chapters of the book deal with applications: membrane protein in vitro folding and cell-free expression, solution studies, NMR, crystallography, electron microscopy, mass spectrometry, amphipol-mediated immobilization of membrane proteins, and biomedical applications.Important features of the book include introductory sections describing foundations as well as the state-of-the-art for each of the biophysical techniques discussed, and topical tables which organize a widely dispersed literature. Boxes and annexes throughout the book explain technical aspects, and twelve detailed experimental protocols, ranging from in vitro folding of membrane proteins to single-particle electron cryomicroscopy, have been contributed by and commented on by experienced users.Membrane Proteins in Aqueous Solutions offers a concise, accessible introduction to membrane protein biochemistry and biophysics, as well as comprehensive coverage of the properties and uses of conventional and non-conventional surfactants. It will be useful both in basic and applied research laboratories and as a teaching aid for students, instructors, researchers, and professionals within the field.

This book introduces and reviews all of the currently available methods being used for computational electroencephalogram (EEG) analysis, from the fundamentals through to the state-of-the-art. The aim of the book is to help biomedical engineers and medical doctors who use EEG to better understand the methods and applications of computational EEG analysis from a single, well-organized resource.Following a brief introduction to the principles of EEG and acquisition techniques, the book is divided into two main sections. The first of these covers analysis methods, beginning with preprocessing, and then describing EEG spectral analysis, event-related potential analysis, source imaging and multimodal neuroimaging, and functional connectivity analysis. The following section covers application of EEG analysis to specific fields, including the diagnosis of psychiatric diseases and neurological disorders, brain-computer interfacing, and social neuroscience.Aimed at practicing medical specialists, engineers, researchers and advanced students, the book features contributions from world-renowned biomedical engineers working across a broad spectrum of computational EEG analysis techniques and EEG applications.

This book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidic mesophases, or living cells. The final chapters of the book deal with applications: membrane protein in vitro folding and cell-free expression, solution studies, NMR, crystallography, electron microscopy, mass spectrometry, amphipol-mediated immobilization of membrane proteins, and biomedical applications.Important features of the book include introductory sections describing foundations as well as the state-of-the-art for each of the biophysical techniques discussed, and topical tables which organize a widely dispersed literature. Boxes and annexes throughout the book explain technical aspects, and twelve detailed experimental protocols, ranging from in vitro folding of membrane proteins to single-particle electron cryomicroscopy, have been contributed by and commented on by experienced users.Membrane Proteins in Aqueous Solutions offers a concise, accessible introduction to membrane protein biochemistry and biophysics, as well as comprehensive coverage of the properties and uses of conventional and non-conventional surfactants. It will be useful both in basic and applied research laboratories and as a teaching aid for students, instructors, researchers, and professionals within the field.

This book introduces and reviews all of the currently available methods being used for computational electroencephalogram (EEG) analysis, from the fundamentals through to the state-of-the-art. The aim of the book is to help biomedical engineers and medical doctors who use EEG to better understand the methods and applications of computational EEG analysis from a single, well-organized resource.Following a brief introduction to the principles of EEG and acquisition techniques, the book is divided into two main sections. The first of these covers analysis methods, beginning with preprocessing, and then describing EEG spectral analysis, event-related potential analysis, source imaging and multimodal neuroimaging, and functional connectivity analysis. The following section covers application of EEG analysis to specific fields, including the diagnosis of psychiatric diseases and neurological disorders, brain-computer interfacing, and social neuroscience.Aimed at practicing medical specialists, engineers, researchers and advanced students, the book features contributions from world-renowned biomedical engineers working across a broad spectrum of computational EEG analysis techniques and EEG applications.

In modern medicine, imaging is the most effective tool for diagnostics, treatment planning and therapy. Almost all modalities have went to directly digital acquisition techniques and processing of this image data have become an important option for health care in future.

A presentation of the most elementary form of pulsatile flow as an important prerequisite for the study of other flow applications in biological systems.

Subjects in the monograph "Biophysics of the Failing Heart" include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise.

A review of our current understanding of the physical phenomena associated with the flow of blood through the brain, applying these concepts to the physiological and medical aspects of cerebrovascular disease so as to be useful to both the scientist and the clinician.

Written by faculty members at Moscow State University, this updated second edition has succinct and authoritative coverage of an array of biophysical topics and models. It deploys mathematical approaches relevant to a wide range of simulated systems.

Brain-computer interfaces (BCIs) are devices that enable people to communicate via thought alone. However, BCIs are now becoming practical tools for a wide variety of people, in many different situations. This book, written by many of the top BCI researchers and developers, reviews the latest progress in the different components of BCIs.

Praise for Hemo-Dynamics: "This book provides an elegant and intuitive derivation of the fundamental mathematics underlying fluid flow, and then applies these in a straightforward way to pulsatile blood flow in all its complexity.

Membrane Biophysics is tailored for readers who want to understand biological processes by applying both simple observations and scientific analysis. The text explores the causes and effects of membrane processes, and will eventually open new doors for pharmaceutical approaches to related diseases.

The topic of this book is the development of automated and inexpensive tools that transfer medical tests from a specialized clinical laboratory directly to the point of care, using biochip technology. They can use this book as a review of the field and as a guide for the development of novel biochip technology for point of care medicine.

In addition to surveying the latest developments in our understanding of the respiratory system, this book on a topic boosted by recent advances in imaging and computational fluid dynamics disentangles the complexities and includes guidelines on best practice.

With growing connections between physics and the life sciences, this text introduces the terminology and the biological systems physicists encounter. It sets out the dynamics of complex systems, and provides a problem-solving challenge from the literature.

Provides the professional with an overview of current methodologies in the field, with emphasis on the implementation of current research.

This book deals with medical and biological physics. A survey is given on properties and applications of biocompatible materials. The are used to substitute malfunctional human organs.

This book reviews the neural theory and translates them into digital models. It gives applications in image recognition, foveation, image fusion and information extraction, and includes Python scripts that help readers replicate results presented in the text.

NanoBiosensing covers the full scope of the field, combining the newest research results in chemistry, biology, and materials science with biosensing and bioanalysis. The text covers important types of nanomaterials for biosensing applications, as well as sensing principles.

However, due to current advances in modern physical, biological sciences, and technologies, our understanding of the methods have evolved to a new level. The book also provides a link to the engineering of novel advanced materials playing an important role in advancing technologies in various fields.

This book provides the basics of odor, odor analysis techniques, sensors used in odor analysis and overview of odor measurement techniques. For beginners as well researchers this book is a brief guide for odor measurement and analysis.

Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues.