Books in the Chromatographic Science Series series

Organized by two leaders in the field, this text establishes a sound fundamental basis for the principles of the two-dimensional liquid chromatography technique, followed by a discussion of important practical considerations.

This book provides a comprehensive source of knowledge of new sorbent materials, presenting fundamental principles for their syntheses, and adsorption properties. It presents advanced techniques employed to create specialized sorbents with a wide range of functions, which can be used to enhance the separation and/or purification of useful bioact

This book discusses flow perturbation method, namely, the stopped-flow technique and the reversed-flow technique. It is directed to those who need an accurate method for the determination of a certain physicochemical quantity and to researchers working on the development of gas chromatography.

This book describes the various aspects of microbore column chromatography. It provides readers with an in-depth understanding of the supercritical fluid chromatography and microbore high-performance liquid chromatography.

Focusing on recent developments in microfluidic lab-on-a-chip technologies, this book offers an overview of the limitations and breakthroughs of this technology over the years. The author emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separat

Preparative Layer Chromatography explains how this method is used for separating large quantities of mixtures containing a wide variety of important compounds. It offers a broad review of preparative layer chromatography (PLC) applications and adaptable working procedures for microseparations involving organic, inorganic, and organometallic compoun

Offering well-rounded coverage of the most significant technological developments in the past few years, this classic work explains how to use LC-MS technology and interpret LC-MS data for various disciplines. This edition places a stronger emphasis on applications, dedicating more than two-thirds of the text to examining LC-MS in emerging areas

Worldwide experts in thin layer chromatography (TLC) applications in diverse fields discuss the separation, identification, quantification, and isolation of medicinal plant components. Part I offers a current overview of TLC and phytochemistry. Part II emphasizes real strategies and procedures for analyzing all types of primary and secondary pla

Now in its second edition, this updated text examines new advances and concepts in the field. Topics include monolithic columns, bonded stationary phases, micro-HPLC, two-dimensional comprehensive liquid chromatography, gradient elution mode, retention models for ions, and capillary electromigration techniques. It addresses HPLC detectors, LC-MS

An up-to-date, complete reference, this book covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. Part I is devoted to gener

This book serves as a comprehensive source of information and training on the state-of-the-art pesticide residues methods performed with aid of HPLC and aids the readers in avoiding the many pitfalls that are possible during work with the HPLC mode

This book focuses on a relatively new approach to chemical analysis in general, and to separation science in particular. It is the first book to systemically cover the theoretical background, techniques, instrumentation, and practical applications of planar chromatography - mass spectrometry as a hyphenated tool of analytical chemistry. It also

This thoughtfully constructed edited reference presents the main chromatographic methodologies and strategies used to discover and analyze novel designer drugs contained in diverse biological materials.

An up-to-date reference that presents the most important information about each area of chemometrics used in chromatography, demonstrating its effective use when applied to a chromatographic separation.

Xenobiotics are chemical compounds foreign to a given biological system. This reference will help the analyst develop effective and validated analytical strategies for the analysis of hundreds of different xenobiotics on hundreds of different sample types, quickly, accurately and at acceptable cost.

This detailed handbook covers different chromatographic analysis techniques and chromatographic data for compounds found in air, water, soil, and sludge. The new edition outlines developments relevant to environmental analysis, especially when using chromatographic mass spectrometric techniques. It addresses new issues, new lines of discussion,

This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to proteins, the text explores the many applications of HILIC in the analytical field. Winner of the President''s Award for Excellence, the author explains how HILIC can significantly improve analytical throughput by shortening sample preparation procedure, which is one of the bottlenecks for drug discovery and development in the pharmaceutical industry.

This book focuses on a relatively new approach to chemical analysis in general, and to separation science in particular. It is the first book to systemically cover the theoretical background, techniques, instrumentation, and practical applications of planar chromatography ¿ mass spectrometry as a hyphenated tool of analytical chemistry. It also examines the high and as-yet unexploited potential of planar chromatography¿mass spectrometry for analytical use in scientific investigations and promotes its expanded use in academia and industry.

A great deal of confusion and uncertainty over genotoxic impurity (GTI) identification, assessment, and control exists. This book strives to facilitate scientific and systematic consensus on GTI management by presenting rationales, strategies, practices, and case studies from the pharmaceutical industry. Exploring the safety, quality, and regulatory aspects of GTIs, the text explains the how and why of various GTI control tactics and practices, including GTI control examples in drug substance and drug product development processes from large and small pharmaceutical firms in multiple geographical regions.

Comprehensively covers the design, construction, and operation of gas chromatography, liquid chromatography, and thin-layer chromatography detectors. This title emphasizes the essential use of common specifications to describe various detectors, allowing easy comparison of their attributes.

Explores the chromatographic methods used for the measurement of drugs, impurities, and excipients in pharmaceutical preparations - such as tablets, ointments, and injectables. This title contains a table listing the chromatographic data of over 1300 drugs and related substances - including sample matrix analyzed and sample handling procedures.

Presents practical information on the application of capillary electrophoresis (CE) to protein analysis, with an emphasis on developing and optimizing CE techniques in the laboratory. This title includes separation methods bases on mass, charge, isoelectric point, molecular sieving, and affinity interactions.

Discusses a model for the propagation of a finite concentration zone in a chromatographic column for the case of a single component sample, and explores operating conditions of ion-exchange chromatography for the production of albumin from bovine serum and plasma.

Presenting a constructive evaluation of the most significant developments in liquid chromatography - mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, this title offers coverage of the technological developments and applications.

This is the first book that comprehensively and systematically describes the new technology of hydrophilic interaction liquid chromatography (HILIC). Hydrophilic interaction chromatography is a separation technique suitable for polar and hydrophilic compounds and orthogonal to reversed phase liquid chromatography. From small organic molecules to proteins, the text explores the many applications of HILIC in the analytical field. Winner of the President's Award for Excellence, the author explains how HILIC can significantly improve analytical throughput by shortening sample preparation procedure, which is one of the bottlenecks for drug discovery and development in the pharmaceutical industry.

This volume is the first book to give a complete description of the techniques, materials, and instrumentation of column HPLC and its application to essentially all primary and secondary plant metabolites. It describes the techniques and instrumentation of HPLC analysis, such as HPLC/nuclear magnetic resonance spectrometry, HPLC with photodiode array detection, and HPLC chiral analysis. It explores the application of HPLC to primary and secondary plant metabolites and discusses how HPLC is used for analyzing herbal drugs and dietary supplements.

Covering definitions, concepts, and applications, this title recounts the developments in two types of liquid-liquid chromatography termed countercurrent-high-speed countercurrent chromatography (HSCCC) and centrifugal partition chromatography (CPC).

This book provides a detailed description of technical elements of a microbore column liquid chromatograph suitable for use in trace analysis. It presents examples of analyses, especially from the spheres of biochemistry, pharmacology, and environmental analytical chemistry.

Considers three fundamental aspects of molecular interactions important in chromatography, taking care not to duplicate information readily available in other references. Surveys the basic factors involved in complex formation, which governs the retention mechanism and selectivity in either donor or