Books in the Colloquium Series on Neuropeptides series

The prohormone convertases (PC) 1/3 and 2 are calcium-activated eukaryotic subtilisins with low pH optima which accomplish the limited proteolysis of peptide hormone precursors within neurons and endocrine cells. This title reviews the biochemistry, regulation, and roles of PC1/3 and 2 in disease, with an emphasis on the work published in the last 10 years.

Describes the general structure of G protein-coupled receptors, including the information obtained from crystal structure determination that has given an insight into the activation mechanism of these receptors. In addition, the book summarizes the components of the signal transduction system (including G proteins, effectors and second messengers generally activated by the neuropeptide receptors).