Books in the Computational Biology series

The field of bioinformatics continues to develop energetically. This second edition covers new findings using the formula of the original text. It is self-contained, bringing together the multiple disciplines necessary for a profound grasp of the field.

Specifically, it discusses an array of techniques related to biological network clustering, network summarization, and differential network analysis which enable readers to uncover the functional and topological organization hidden in a large biological network.

This book describes core processes of replication, mutation, neutral evolution and natural selection, genome evolution in prokaryotes, eukaryotes, vertebrates and humans, genome sequencing amd more, offering worked-out examples and extensive appendices.

This interpretation enables a remarkably unified view of the entire field of biology to be taken and hence offers an excellent entry point into the life sciences for those for whom biology is unfamiliar.

This book explores association mapping in experimental populations and genome-wide association studies (GWAS), emphasizing methods based on modifications of Bayesian information criterion, for handling testing problems in large-scale scans for trait loci.

This unique textbook/reference presents unified coverage of bioinformatics topics relating to both biological sequences and biological networks, providing an in-depth analysis of cutting-edge distributed algorithms, as well as of relevant sequential algorithms.

The advances of live cell video imaging and high-throughput technologies for functional and chemical genomics provide unprecedented opportunities to understand how biological processes work in subcellularand multicellular systems. The interdisciplinary research field of Video Bioinformatics is defined by BirBhanu as the automated processing, analysis, understanding, data mining, visualization, query-basedretrieval/storage of biological spatiotemporal events/data and knowledge extracted from dynamic imagesand microscopic videos. Video bioinformatics attempts to provide a deeper understanding of continuousand dynamic life processes.Genome sequences alone lack spatial and temporal information, and video imaging of specific moleculesand their spatiotemporal interactions, using a range of imaging methods, are essential to understandhow genomes create cells, how cells constitute organisms, and how errant cells cause disease. The bookexamines interdisciplinary research issues and challenges with examples that deal with organismal dynamics,intercellular and tissue dynamics, intracellular dynamics, protein movement, cell signaling and softwareand databases for video bioinformatics.Topics and Features. Covers a set of biological problems, their significance, live-imaging experiments, theory andcomputational methods, quantifiable experimental results and discussion of results.. Provides automated methods for analyzing mild traumatic brain injury over time, identifying injurydynamics after neonatal hypoxia-ischemia and visualizing cortical tissue changes during seizureactivity as examples of organismal dynamics. Describes techniques for quantifying the dynamics of human embryonic stem cells with examplesof cell detection/segmentation, spreading and other dynamic behaviors which are important forcharacterizing stem cell health. Examines and quantifies dynamic processes in plant and fungal systems such as cell trafficking,growth of pollen tubes in model systems such as Neurospora Crassa and Arabidopsis. Discusses the dynamics of intracellular molecules for DNA repair and the regulation of cofilintransport using video analysis. Discusses software, system and database aspects of video bioinformatics by providing examples of5D cell tracking by FARSIGHT open source toolkit, a survey on available databases and software,biological processes for non-verbal communications and identification and retrieval of moth imagesThis unique text will be of great interest to researchers and graduate students of Electrical Engineering,Computer Science, Bioengineering, Cell Biology, Toxicology, Genetics, Genomics, Bioinformatics, ComputerVision and Pattern Recognition, Medical Image Analysis, and Cell Molecular and Developmental Biology.The large number of example applications will also appeal to application scientists and engineers.Dr. Bir Bhanu is Distinguished Professor of Electrical & C omputer Engineering, Interim Chair of theDepartment of Bioengineering, Cooperative Professor of Computer Science & Engineering, and MechanicalEngineering and the Director of the Center for Research in Intelligent Systems, at the University of California,Riverside, California, USA.Dr. Prue Talbot is Professor of Cell Biology & Neuroscience and Director of the Stem Cell Center and Core atthe University of California Riverside, California, USA.

Navigating safely through a wealth of genome, protein and metabolite information, as well as a host of information processing tools, without getting lost is crucial for successful research in - and teaching of - molecular biology.This concise, easy-to-follow textbook/guide serves as a valuable introduction to contemporary cell biology for readers and offers insight into the key research directions in the field. It begins with an overview of existing tools for finding, designing and investigating metabolic, genetic, signalling and other network databases. This practical guide then introduces Cell Illustrator®, a software tool for biological pathway modelling and simulation, developed by the authors. In-depth discussion reveals how this tool can be used for creating, analyzing and simulating biological models, thereby explicating and testing current understanding of basic biological processes. Readers do not require prior knowledge of differential equations or programming.Features:¿ Provides many helpful learning aids, such as detailed examples throughout, and exercises and solutions¿ Designed and structured to be part of a semester-long course¿ Discusses the computational functionalities required for Systems Biology¿ Addresses practical issues surrounding software tools¿ Introduces the current big bio-databases such as TRANSPATH® by Biobase, and explains why and how they can be used to develop and support systems biology research¿ Explains important pathway databases and software tools, together with their related concepts¿ Guides the reader to model pathways in a step-by-step and clear manner>Written for undergraduates, this reader-friendly introduction to the field of Systems Biologyoffers insight and teaches sound expertise in the subject. It will also prove valuable to graduate students and professionals wishing to develop and support their systems-biology research.