Books in the Drug Discovery series

This is the first book to examine the future opportunities and challenges in the development of drugs which target kinases

The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies.

This is a wide scope and in-depth coverage of the state of the art and future directions in drug discovery for major psychiatric disorders.

An integrated review of the most recent trends in natural products drug discovery and key lead candidates that are outstanding for their chemistry and biology in novel drug development.

A rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.

This book, aimed at academics, industrialists and post-graduates, documents the latest research into computer aided drug design.

This unique book focuses on the currently 'hot topic' of Pharmaceutical Salts and Co-crystals. Combining both reports of the latest academic research and comprehensive overviews of basic principles, with more applied contributions from selected experts in industry.

This book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry by informing them about the breadth of the work carried out in chemical research and development departments. It is also of great value to academics wishing to advise students on the merits of careers in chemical development over discovery.

This book will review macrocycles in drug discovery and will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.

This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.

This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. It covers both synthetic technologies currently impacting medicinal chemistry and emerging areas.

An invaluable guide to successful practice in neglected tropical diseases (NTDs) and highlights best practice to guide the ongoing drug discovery effort.

This is the first comprehensive description of the discovery and therapeutic potential of polyamine drugs.

This book considers the relationship between structure and function in G protein-coupled receptors (GPCRs) and the implications for drug design.

The Medicinal Chemist's Guide to Solving ADMET Challenges presents state-of-the-art design strategies by a global group of experienced medicinal chemists and ADMET experts across academia and the pharmaceutical industry.

Shows how different parts of the drug discovery process have developed, with particular emphasis on quantitative aspects and possible future progress.

This thorough and up-to-date insight into predictive technologies considers what is on the horizon for safety prediction in human health.

This exemplary book gives an up-to-date perspective on the role of metal ions in neurodegeneration.

Describes proteolytic enzymes and their biological function to aid drug discovery by detailing methods of production and assay of the enzymes.

A volume that will provide a mechanism-based approach to understanding Chinese medicine for both Western and Eastern scientists.

New Tools to Interrogate Endocannabinoid Signalling comprehensively covers the innovative research into both natural and synthetic compounds. This timely volume will be a valuable resource to pharmaceutical researchers and medicinal chemists working in natural products and endocannabinoid drug discovery in academia and industry.

Antibody-drug conjugates are a promising areas of anticancer drug discovery, conveying several advantages, including the ability to select likely responders, efficient delivery of cytotoxic agents and reduced toxicity. This book describes payloads used to date and novel payloads that may be used clinically in the future.