Books in the Handbook of Analytical Separations series

Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods. Features descriptions and applications of all separation methods used in the pharmaceutical industryWritten by the leading scientists in their respective fields, providing solutions for a wide range of industrial separation problems encountered within the pharmaceutical industryThoroughly updated with brand new separation science techniques and the latest developments in the established techniques of chromatography

Part of the multi-volume series, "Handbook of Analytical Separations", providing reviews of analytical separation methods and techniques used for the determination of analytes across a range of applications. This book discusses developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids.

Presents the applications of separation methods, mainly chromatography, in forensic practice. This book contains reviews on forensic relevant groups of compounds. It presents application of separation methods in forensic chemistry. It contains chapters on forensic genetics.

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of usersWritten by authors from international labs, providing a global perspective that can be applied in various regulatory environmentsFeatures additional therapeutic drugs to reflect the rising number of immunocompromised patientsIncludes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Part of the "Handbook of Analytical Separations" series, this volume gives an overview about methods to analyse drugs in biological fluids. It covers the general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies. It discusses areas where therapeutic drug monitoring is used frequently.

Covers a compilation of analytical methods for the determination of a wide range of environmental priority pollutants, including amines, polycyclic aromatic hydrocarbons, pesticides, phenols, PCBs, as well as organometallic species, polycyclic aromatic sulphur heterocycles and metabolites of polycyclic aromatic hydrocarbons.