Books in the IPEM-IOP Series in Physics and Engineering in Medicine and Biology series

Soft Biological Shells in Bioengineering integrates existing experimental data to construct multiscale models of various organs of the human body: the stomach, gravid uterus, urinary bladder, the small intestine and the large intestine. These models are used as in silico platforms to study intricate physiological and pathophysiological processes, and to assess pharmacological modulations on their dynamics. This book will be of value to postgraduate students, researchers and medical doctors interested in computational systems biology.

Flow Dynamics and Tissue Engineering of Blood Vessels explores the physical phenomena of vessel compliance and its influence on blood flow dynamics, as well as the modification of flow structures in the presence of diseases within the vessel wall or diseased blood content. This volume also illustrates the progress of tissue engineering for the intervention of re-engineered blood vessels. Blood vessel organoid models, their controlling aspects, and blood vessels based on microfluidic platforms are illustrated following on from the understanding of flow physics of blood on a similar platform.The purpose of this book is to provide an overview of regenerative medicine and fluid mechanics principles for the management of clinically diseased blood vessels. Authors discuss tissue engineering aspects and computational fluid mechanical principles, and how they can be used to understand the state of blood vessels in diseased conditions.Key FeaturesComputational and experimental fluid dynamics principles have been used to explore the modelling of diseased blood vesselsPrinciples of fluid dynamics and tissue engineering are used to propose innovative designs of bioreactors for blood vessel regenerationOffers experimental analytical studies of blood flow in vessels with pathological conditionsControlling aspects of various parameters while developing blood-vessel bioreactors and organoid models are presented critically, and optimization techniques for these parameters are also provided

This volume presents the applications of Nanotechnology to different fields of dentistry. Recognized dental specialities such as orthodontics, endodontics and prosthodontics have been covered in addition to general dentistry applications of nanotechnology. The book, in a comprehensive fashion, delves into such technologies as drug nanocarriers, nanomaterials, implants and other nanoparticle applications related to dentistry, and shows how these, in turn, will enhance therapeutic effects against dental bacteria and erosion. This book not only presents the current trends in dental therapies but also presents the current research trends and potential applications. A bottom-up approach has been mostly adopted to suit the need of a wide audience including novice researchers and post graduate students.Key Features: Each chapter includes brief review in the initial paragraphs followed by recent trendsContent level designed to suit the needs of technicians in addition to novice researchersThere is necessary minimum overlap from available literatureA number of the chapter authors are highly esteemed researchers in their prospective fieldsUnique coverage of such topics as nanorobotic local anesthetics, neurotoxticity, nano endodontic sealers, orthodontic nanorobots, nanodiagnostics

Applying the general deterministic approach of systems computational biology, the monograph considers questions related to the biomechanics of the human urinary bladder in conjunction with the peripheral and central nervous systems. The step-by-step development of mathematical models of separate structural elements and their assembly into a unique self-regulatory system offers, for the first time, a holistic overview and allows the investigation of the dynamics of the lower urinary tract system at its hierarchical levels. This book provides a coherent description and explanation for intertwined intracellular pathways in terms of spatiotemporal, whole body, tractable representations which are supported by numerous computational simulations.Key FeaturesIt reconstructs accurately the cytoarchitecture and morphofunctional relationships between the elements of the central nervous (brain) and genitourinary (urinary bladder system).Offers for the first time a both quantitative and qualitative, assessment of the neurohormonal and mechanobiological processes involved in the process.Provides a comprehensive description for intertwined regulatory pathways in terms of spatiotemporal dynamic representations.Encourages the reader to develop and apply a unique holistic approach to solving complex biomedical problems in the area of growth and remodeling of the urinary bladder through application of modern methods of computational biology.

This book provides a comprehensive overview of the role of 3D/4D ultrasound imaging in radiotherapy. It identifies barriers to the clinical implementation of ultrasound-guided radiotherapy, and provides a critical discussion of potential solutions as well as highlighting exciting new opportunities for research in this field.

This book, written by leading researchers and medical doctors in the field, provides an overview of intensity modulation technology and its evolution over the last 35 years. Every aspect of IMRT is covered, from fundamental concepts to advanced processes and clinical applications, and comprehensive references are included.

Biopotential signals are often used by physicians to measure the activities of organs and tissues in the human body. This book describes the sources and characteristics of different biopotential signals and provides an understanding of how a range of signals can be modelled and analysed. The resulting information can be used to assist in the identification of disorders such as epilepsy, schizophrenia, PTSD and heart disease, among others. An emphasis is placed on the real challenges in biopotential signal processing due to the complex and non-stationary nature of signals.Following on from volume one, this book starts with a collection of chapters covering some of the latest developments in electroencephalography (EEG) signal analysis, then moves on to applications of electrocardiography (ECG) and otoscope signals. The volume concludes with a discussion of other monitoring techniques. The chapters include biomedical examples and discussions of how each method can be used to study human organs. It is a valuable guide for all researchers and practitioners who are engaged in studies and research in the area of biomedical signals and their applications.Key FeaturesModelling and acquisition of biomedical signals for different disordersImplementation of methodologies and their impact on different casesCase studies and research directions Design and simulation examples

This book looks at analysis and modelling of active biopotential signal processing. It emphasises the real-time challenges in biomedical signal processing that occur due to the complex and non-stationary nature of signals in a variety of applications for analysis, classification and identification of different states for improvement of healthcare systems. The main focus of the book is on modelling; acquisition of biomedical signals for different disorders; implementation of methodologies and their impact on different cases; case studies and research directions; automatic identification of related disorders; design and simulation examples; and issues and challenges. Overall, the book addresses the real-time challenges in biomedical signal processing used in a variety of applications such as analysis, classification and identification of different disorders in healthcare systems. It is a valuable guide for all researchers and practitioners who are engaged in studies and research in the area of biomedical signals and their applications. Key Features Modelling and acquisition of biomedical signals for different disordersImplementation of methodologies and their impact on different casesCase studies and research directionsDesign and simulation examples

This book aims to teach students, instructors and professionals the basis of optical techniques for biomedical investigation. It is a text for researchers active at the interface between biology, medicine and optics. With the format of a classical textbook, this work contains the underlying theory of biological optics and applications to real laboratory problems, via exercises and homework.

Lasers in Medical Diagnosis and Therapy: Basics, applications and future prospects provides an overview on medical lasers and laser systems as well as laser applications in medical diagnosis and therapy. Since it was written by physicists, it focusses on the physics and underlying mechanisms of laser diagnosis and therapy.

Principles of Biophotonics, volume two describes detection and statistical representation of optical fields. Beginning by placing the visible spectrum in the context of the electromagnetic frequency range, this presentation stresses how thin of a sliver is normally called the optical spectrum. In addition to describing properties of light with technical accuracy, the most common radiometric quantities are introduced, and conversion to photon-based quantities is explicitly presented. For completeness, an analogy to the photometric quantities is also made, and the three fundamental mechanisms for generating light, blackbody radiation, fluorescence and laser emission, are covered. Each chapter contains a set of practice problems and additional references, and this book aims to build the foundation for further study in subsequent volumes.

Design and Shielding of Radiotherapy Treatment Facilities provides readers with a single point of reference for protection advice to the construction and modification of radiotherapy facilities. The book assembles a faculty of national and international experts on all modalities including megavoltage and kilovoltage photons, brachytherapy and high-energy particles, and on conventional and Monte Carlo shielding calculations. This book is a comprehensive reference for qualified experts and radiation-shielding designers in radiation physics and also useful to anyone involved in the design of radiotherapy facilities.

This book provides a review of the history and technologies in the development of computational small animal models, with a focus on their application in preclinical imaging, radiation therapy and dosimetry calculations. It provides an overview of model design of computational models, identification of anatomical data, the tools used for solving problems and animal model application in preclinical research.

Anthropomorphic Phantoms in Image Quality and Patient Dose Optimization: A EUTEMPE Network book is invaluable for medical physicists and biomedical engineers, and it is unique in its form and content. The book focuses on the practical applications of anthropomorphic phantoms for research and educational purposes, and includes tutorials and self-training examples.

This book covers the principles, advantages and potential pitfalls that occur in proton therapy, especially its radiobiological modelling applications. It is intended to educate, inform and stimulate further research questions by blending the relevant physics, biology and medical aspects of this multidisciplinary subject.

This book is essential reading for medical physicists in radiation protection, diagnostic radiology and nuclear medicine, as well as radiographers and technologists, due to changes in global dosimetry requirements. Additionally, it presents guidelines for medical physicists and others using radiation.

Nano drug-delivery systems responding to cellular local stimuli, such as pH, temperature and reductive agent's activation, i.e. enzymes, could effectively provide passive-mode desirable release but fail in disease treatment following the biological rhythms of brain tumor. This book is a compilation of research development lead by expert researchers and it establishes a single reference module. It addresses, for the first time, all translational aspects and clinical perspectives of physically stimulated breast-cancer nanotheranostics from a wide-ranging and multidisciplinary perception providing unrivalled and comprehensive knowledge in the field.

Biomechanical Modeling of the Cardiovascular System brings together the challenges and experiences of academic scientists, leading engineers, industry researchers and students to enable them to analyse results of all aspects of biomechanics and biomedical engineering. It also provides a springboard to discuss the practical challenges and to propose solutions on this complex subject.

A learning and revision resource for those studying for radiology fellowship examinations. Updated with more than 50 new questions, and a new chapter on functional and molecular imaging.

Magnetic Nanoparticles for Medical Diagnostics aims to encourage members of the medical profession to join experts from other fields of research in exploring the unique physical properties of magnetic nanoparticles for medical applications.