Books in the Methods and Principles in Medicinal Chemistry series

By addressing both drug efficiency and drug safety, this modern practical reference shows how each aspect shapes the key decisions for assessing the risk/benefit ratio of any novel compound during the early drug development stages, using both in vitro and in silico methods.

Explains the identification of molecular targets via cellular assays, reporter genes or transgenic models. This title also presents a survey of the advances in the synthesis, separation and analysis of drugs. It also contains a special section devoted to molecular genetics methods.

Combinatorial chemistry is a revolutionary method, which allows you to synthesize millions of compounds within a few steps and in a very short amount of time. Millions of products, e.g. potential drugs, can be analyzed in one go, so that you know very fast if one or a few substances in your product mixture show biological activity.

The first overview of mass spectrometry-based pharmaceutical analysis, this reference is the key to high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. Contains contributions from leading pharma companies and pharmaceutical research institutions.

This practice-oriented handbook highlights all issues relating to chirality of pharmaceuticals, from challenges in the synthesis of these complex molecules to analytical techniques to aspects of pharmacology and drug development. It is highly useful for every medicinal chemist involved in small molecule drug development.

The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten. In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche.

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.

A timely and topical survey of modern simulation tools and their applications in realΓÇôlife drug discovery, allowing for better and quicker results in structureΓÇôbased drug design. The first part of this practical guide for industry professionals describes common tools used in the biomolecular simulation of drugs and their targets. A critical analysis of the accuracy of the predictions, the integration of modeling with other experimental data combined with numerous case studies from different therapeutic fields enable users to quickly adopt these new methods for their current projects. The second part then shows how these tools can be applied to drug discovery and development projects. Modeling experts from the pharmaceutical industry and from leading academic institutions present realΓÇôlife examples for important target classes such as GPCRs, kinases and amyloids as well as for common challenges in structureΓÇôbased drug discovery. With its inclusion of novel methods and strategies for the modeling of drugΓÇôtarget interactions in the framework of realΓÇôlife drug discovery and development, this applicationΓÇôoriented reference is tailorΓÇômade for medicinal chemists and those working in the pharmaceutical industry.

Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results.

The complete picture of methods and strategies in industrial and academic lead finding and optimization, covering standard as well as novel approaches and highlighting their strengths and weaknesses. Includes several case studies of recent successful lead generation projects.