Books in the Methods & Principles in Medicinal Chemistry series

Combinatorial chemistry is a revolutionary method, which allows you to synthesize millions of compounds within a few steps and in a very short amount of time. Millions of products, e.g. potential drugs, can be analyzed in one go, so that you know very fast if one or a few substances in your product mixture show biological activity.

Explains the identification of molecular targets via cellular assays, reporter genes or transgenic models. This title also presents a survey of the advances in the synthesis, separation and analysis of drugs. It also contains a special section devoted to molecular genetics methods.

This practical referene for drug developers addresses the most common antitarget-related side effects, including hepatic, cardiovascular, kinase- and GPCR-mediated toxicity. Current strategies how to manage side effects as well as several case studies are included.

Key content for every medicinal chemist: The understanding of ligand-target interactions is the basic skill that every medicinal chemist needs.

Drug discovery is all about finding small molecules that interact in a desired way with larger molecules, namely proteins and other macromolecules in the human body. If the three-dimensional structures of both the small and large molecule are known, their interaction can be tested by computer simulation with a reasonable degree of accuracy.

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.

Written by the pioneers of the sildenafil (Viagra) phosphodiesterase inhibitor drug, this timely reference discusses emerging applications of novel PDE inhibitors in a variety of disease fields with contributions from major pharmaceutical companies.