Books in the Monographs in Epidemiology and Biostatistics series

This book describes the biology, occurrence, and methods of control of the commonest congenital malformations of the nervous system: neural tube defects, spina bifida, encephalocoele, and anencephalus. It reviews the epidemiology of these conditions and discusses issues such as ascertainment, seasonal variation, ethical and legal issues.

This text for graduate students in epidemiology and biostatistics describes the statistical tools that are currently used in the analysis of proportions and disease rates and on model fitting. Among the topics covered are Man-Haenszel methods, survival analysis, logistic regression, and generalized linear models.

This book is based on Kahn's An Introduction to Epidemiological Methods (OUP, 1983). As the title change indicates, its discussion of the statistical concepts and methods that are fundamental to epidemiology has been substantially expanded. New material and two new chapters have been added, as well as an appendix of data from the Framingham Heart Study.

This is the first comprehensive text about the design and analysis of community or group-randomized trials, which are usually done to evaluate the effect of health promotion efforts. It reviews the underlying issues, describes the most widely used research designs, and presents the many approaches to analysis that are now available.

This textbook is an integrated account of the application of statistics to biomedical data. Using the S-Plus computer language, it combines theory, applications and interpretation to present the entire process of biostatistical reasoning for a series of elementary and intermediate methods.

This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.

Confronting problems unique to AIDS research, this study focuses on the creation of methods for the design and analysis of epidemiological data, the natural history of AIDS, methods for tracking and projecting the course of the epidemic, and statistical issues on therapeutic trials.

A comprehensive introduction to meta-analysis, decision analysis, and cost-effectiveness analysis. These three closely related methods have become even more important for synthesizing research since the first edition and have gained legitimacy as tools for guiding health policy.

Over the past fifty years, the case-control method, and to a lesser extent its case-based variants, have become the most important tools for the investigator of health problems. The case control method is the study of persons with the disease and a suitable control group of persons who do not have the disease. The book helps readers address a number of general and specific questions dealing with the case-control and other case-based methods, including questions ofhow to design and implement a case-control study that minimizes biases, how to analyze the data to appropriately deal with confounding variables and help identify reactions, and how to interpret data and present the results from a case-control study.

This text provides a picture of the design, conduct analysis and interpretation of non-experimental studies of both infectious and non-infectious diseases. This second edition has been thoroughly updated.

Willett's Nutritional Epidemiology has become the foundation of this field. This new edition updates existing chapters and adds new ones addressing the assessment of physical activity, the role of genetics in nutritional epidemiology, and the interface of this field with policy.

The classic, definitive guide to the design, conduct, and analysis of randomized clinical trials.

Examining the principles and methods of research on the evaluation of factors affecting the outcome of illness, this book contains topics as the assessment of the use of diagnostics and screening tests and their role in improving the outcome of illness, and the evaluation of therapeutic efficacy through experimental and non experimental studies.

This popular intermediate-level text continues to focus sharply on clear and practical descriptions of statistical methods for analyzing epidemiological data. Thoroughly revised throughout, the third edition includes a new chapter on Poisson regression analysis, along with many new applied examples and many fresh discussions of key analytic issues.

Provides a critical summary of research approaches to the epidemiological study of workplace hazards. This second edition provides discussions of methods such as case-cohort and case-crossover designs and statistical analysis of repeated measures data, a chapter on occupational health surveillance, and examples involving chronic health outcomes.