Books in the Novartis Foundation Symposia series

The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions.

Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission.

The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic on the scale of the Spanish flu pandemic of 1918.

Acetaldehyde-Related Pathology brings together contributions from experts working on all aspects of acetaldehyde-related pathology in order to better understand the pathogenesis of diseases in which acetaldehyde, from whichever source, is implicated.

Fatty Acid and Lipotoxicity in Obesity and Diabetes deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and beta-cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.

Much recent research in evolutionary developmental biology has focused on the origin of new body plans. However, most evolutionary change at the population and species level consists of tinkering: small-scale alterations in developmental pathways within a single body plan.

Contributors to this book explore existing strategies and examine possible new strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve outstanding problems in the treatment of immunological diseases and chronic infections.

Part of the prestigious Novartis Foundation series, this volume uniquely addresses the use of innate immunity to treat or prevent infectious diseases of the lung.

This book brings together work from a wide range of disciplines to explain processes underlying empathy and fairness. It approaches the topic of empathy and fairness from different viewpoints, namely those of social cognitive neuroscience, developmental psychology, evolutionary anthropology, economics, and neuropathology.

This book features contributions from the world's leading researchers working on dengue and related flaviviruses who examine the current state of the art in the molecular biology of the dengue virus. Particular emphasis is placed on the structure and function of the virus and the targeting of virus proteins by potential antiviral agents.

Cl- absorption and HCO3- secretion are intimately associated processes vital to epithelial function, itself a key physiological activity. Until recently the transporters responsible remained obscure, but a breakthrough occurred with the discovery of the SLC26 transporters family.

Signalling Pathways in Acute Oxygen Sensing- No. 272 brings together contributions from experts in the field of acute oxygen sensing working on different tissues to address the controversies in the filed and their possible origins, and to develop approaches whereby these controversies might be resolved.

Addresses the research on mast cells and basophils and its significance in relation to allergic and autoimmune diseases. This is an area of burgeoning interest, driven by increasing recognition of the fundamental importance of these cell types in several disease processes.

Seemingly simple behaviours turn out, on reflection, to be discouragingly complex. For many years, cognitive operations such as sensation, perception, comparing percepts to stored models (short-term and long-term memory), decision-making and planning of actions were treated by most neuroscientists as separate areas of research.

With contributions from leading cell and developmental biologists, structural biologists, geneticists, and clinical scientists, this book seeks to foster a better understanding of the mechanisms leading to disease pathogenesis.

This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shape change and motility.

This book covers basic issues concerning the nature of the worldwide health problem posed by cigarette smoking and explores the psychodynamics of cigarette addiction. The basic pharmacology and biochemistry of nicotine and its effect on the brain are reviewed here.

Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches.

Neural transplantation can be used to treat neurodegenerative diseases through a variety of methods. The field is at a critical stage in its development, particularly in light of ongoing investigations into Parkinson's disease and alternatives to fetal transplantation.

A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation.

This book features scientists from a broad spectrum of disciplines discussing recent data on aggression in laboratory animals with particular reference to possible implications for understanding human aggression. Chapters focus on the major current experimental issues in the study of aggression in humans and animals.

Over the past five years, there has been dramatic progress in unravelling the cellular circuitry involved in cardiac failure, as well as in normal cardiac growth, development and apoptosis. These studies have revealed new and unanticipated therapeutic targets in the heart.

Insect-Plant Interactions and Induced Plant Defence Chair: John A. Pickett 1999 This book examines the sophisticated mechanisms that plants use to defend themselves against attack by insects and pathogens, focusing on the networks of plant signalling pathways that underlie these defences.

* This book is a comprehensive and up-to-date account of where we stand in immunological strategies for preventing or treating type 1 diabetes (T1D).

In keeping with the Novartis series this book draws together contributions from an international and interdisciplinary group of experts. Involved here are those studying the mechanisms of light signalling to the vertebrate clock, the connections between central and peripheral clocks and the genetics of the vertebrate clock and clock proteins.

The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell.

This book explores the latest research on the role of the sarcoplasmic reticulum (SR) in smooth muscle function. It examines the control and modulation of the SR and how this may vary among smooth muscle types. Potential therapeutic implications are also discussed.

To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system.

The object of this book is to gather together workers in the fields of epilepsy, those concerned with the basic science of resistance and the blood-brain barrier, and those with clinical experience of drug resistance in cancer, with a view to stimulating further work on drug resistance in epilepsy.