Books in the Oxidative Stress and Disease series

This book explores nanoparticles, their chemical and physicals properties, and how they interact in biological systems with proteins, immune systems and targeted cells. Risk assessment of nanoparticles for human use is described, including: cellular paradigms, transcriptomics and toxicogenomics.

This book unravels key physiological responses and adaptations to different redox regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease.

Even before oxygen appeared in our athmosphere, redox reactions provided the energy for metabolic steps in the evolution of life. Redox modifications are now important in cellular functions including differentiation/development. This book compiles current knowledge regarding the roles of redox regulation in differentiation and de-differentiation.

Mammalian heme peroxidase enzymes are critical for immune responses and disease prevention. Although beneficial, overproduction drives development of pathologies, by triggering the initiation of stress-related cell damage and dysfunction. This book highlights the roles of mammalian heme peroxidases, and their involvement in immunity and disease.

This book provides an insightful and useful forum to help understand the relevance of hydrogen peroxide generation in human biology. This book is for readers with an interest in the generation of ROS, but without expertise in chemistry, and experts in oxidative stress, but without detailed understanding of the biologically relevant setting.

Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. This volume highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging. The book examines vitamin D¿s genomic and nongenomic effects, the role of therapeutic analogs in treating disease, and the production of vitamin D by the body. It discusses its role in modulating oxidative stress and regulating the immune response as well as its role in the regulation of the aging process.

An essential resource for scientists and researchers of nutrition, aging, and metabolic diseases, this book highlights the interactions among nutrients, epigenetics, and health. It presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process.

About 30% of the general population suffers from non-alcoholic fatty liver disease, and the incidence of more serious fatty liver disorders increases with obesity. This volume discusses the current understanding of the development of fatty liver disease and reviews its clinical aspects. Expert contributors discuss the absorption and metabolism of fat in the liver and summarize research findings regarding the impact of oxidative stress, inflammation, and nutrition on the disease development and progression.

There is now a large amount of data available for human beings, showing health beneficial hormetic effects of mild stresses from physical, chemical, nutritional, and mental sources. However, these data are dispersed in the literature and not always interpreted as hormetic effects, thus restricting their full apprehension and application. A comprehensive discussion of the research, this book is composed of four sections: (I) History and Terminology, (II) Evidence for Hormesis in Human Beings, (III) Molecular Mechanisms of Hormesis, and (IV) Hormesis in Risk Assessment.

Covers antioxidants in beverages and herbal products, nitric oxide and selenium. This book highlights research on food-derived antioxidants and biomarkers; vitamins E and C; coenzyme Q; carotenoids, flavoroids and other polyphenols; antioxidants in beverages and herbal products; and, the thiol antioxidants glutathione and lipoic acid.

Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. This volume examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. Topics include electron transport and energy production, mitochondrial biogenesis and dynamics, mitochondrial signaling, and apoptosis and autophagy. The book also explores pharmacology signaling and epigenetic signaling, with discussions on mitochondrial methylation and acetylation reactions. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Flavonoids exert a multiplicity of biological effects on humans and can have beneficial implications for numerous disease states. This volume examines current knowledge regarding the absorption, metabolism, and bioavailability of individual flavonoids and related phenolic compounds. Edited by internationally recognized leaders in the field, the book presents contributions by a panel of experts who demonstrate the potential of flavonoids in ameliorating a range of disease states, including cardiovascular disease, Alzheimer¿s and Parkinson¿s disease and other neurodegenerative disorders, and cancer. This research provides a reliable starting point for further inquiry and experimentation.

Discussing the role of dysregulated inflammation and lifestyle in chronic diseases, this book looks at the link between inflammation and a range of disorders such as neurodegenerative, pulmonary, rheumatic, arthritic, gastrointestinal, skin, heart, and infectious diseases; asthma; insulin resistance; cancer; neuropsychiatric disorders; and chronic wounds. For each ailment, contributors review the clinical and scientific literature, examine current and potential therapies, and suggest directions for future research. Exploring how the suppression of pro-inflammatory pathways may provide opportunities for prevention and treatment, the book examines conventional pharmacotherapies such as steroids and NSAIDs alongside anti-inflammatory dietary agents.

Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. This book provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes. Topics include the mechanisms of lipid oxidation, antioxidant defenses, lipid oxidation products, cell signaling, and the roles of oxidized lipids in specific diseases. The book also discusses drug targeting and the therapeutic potential of oxidized lipids

Obesity leads to a host of pathologies, including cardiovascular disease, insulin resistance, and metabolic syndrome. This book focuses on the effects of obesity on systemic inflammation. It addresses the epidemiology of obesity-induced inflammation and the adipokine mediators that link adipose tissue to inflammation.

The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization.

Vitamin C holds a unique place in scientific and cultural history. This book surveys this history also provides updates on recent uses of Vitamin C in cancer therapy, the treatment of infectious disease, and the potential for stem cell transplantation, as well as other health implications.

Flavonoids exert a multiplicity of biological effects on humans and can have beneficial implications for numerous disease states. This volume examines current knowledge regarding the absorption, metabolism, and bioavailability of individual flavonoids and related phenolic compounds. Edited by internationally recognized leaders in the field, the book presents contributions by a panel of experts who demonstrate the potential of flavonoids in ameliorating a range of disease states, including cardiovascular disease, Alzheimer¿s and Parkinson¿s disease and other neurodegenerative disorders, and cancer. This research provides a reliable starting point for further inquiry and experimentation.

High doses of vitamins have been used to treat cancer. This book explores the ways Vitamin C retards cancers through the perturbation of multiple cellular pathways, by eliciting a hypoxic response in cancer cells, by stimulation of radio-sensitivity, and by reprogramming somatic cell activities. A chapter summarizes clinical trials and therapies.

Responding to the increased popularity of herbal medicines and other forms of complementary or alternative medicine world-wide, this reference reviews and evaluates various safety, toxicity, and quality-control issues related to the use of traditional and herbal products for health maintenance and disease prevention and treatment. With over 3,550 references, the book highlights the role of herbal medicine in national healthcare and provides case studies of widely used herbal remedies, their effects on human health and wellness, and the need for methodologically sound clinical trials for herbal medicines.