Books in the Progress in Brain Research series

In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells.

Respiration is one of the most basic motor activities crucial for survival of the individual. It is under total control of the central nervous system, which adjusts respiratory depth and frequency depending on the circumstances the individual finds itself. For this reason this volume not only reviews the basic control systems of respiration, located in the caudal brainstem, but also the higher brain regions, that change depth and frequency of respiration. Scientific knowledge of these systems is crucial for understanding the problems in the many patients suffering from respiratory failure.

Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more.Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences.

The book chapters cover different aspects of epilepsy genetics, starting with the "classical" concept of epilepsies as ion channel disorders. The second part of the book gives credit to the fact that by now non-ion channel genes are recognized as equally important causes of epilepsy. The concluding chapters are designed to offer the reader insight into current methods in epilepsy research. Each chapter is self-contained and deals with a selected topic of interest.

Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences.Volume 210, The Cerebellum and Memory Formation: Structure, Computation and Function, covers topics including feedback control of cerebellar learning; cortico-cerebellar organization and skill acquisition; cerebellar plasticity and learning in the oculomotor system, and more.

Examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume focuses on the neurosciences, neurology, and literature that shows how science and the humanities can come together - and have come together in the past.

A title that reviews the knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery. It includes chapters that are extensively referenced to provide readers with a comprehensive list of resources on the topics covered.

A title that reviews the knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery. It includes chapters that are extensively referenced to provide readers with a comprehensive list of resources on the topics covered.

Suitable for researchers and practitioners entering the field, this title brings together the research on Functional Neural Transplantation. It provides the author's views and perspectives for future research.

Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. This title discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes.

The understanding of how people make decisions is of central interest to experts working in fields such as psychology, economics, movement science, cognitive neuroscience, neuroinformatics, robotics, and sport science. This title investigates the implications of how our brain directs our movements on decision making.

Links findings on the structural development of the human brain, the expression of genes in behavioural and cognitive phenotypes, environmental effects on brain development, and developmental processes in perception, action, attention, cognitive control, social cognition, and language.

There is a critical, bidirectional relationship between sleep and cognition, yet the literature in this area is scattered. This issue of Progress in Brain Research provides a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

Reviews the variety of animal models of PD available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This title covers functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients.

Nitric oxide, 'Molecule of the Year' in 1995, is one of the most widely studied molecules in brain research. This title elucidates the implications of this gas in a variety of brain processes.

Provides an overview on perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This title presents a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods.

Neuroendocrinology is a discipline which originated about 50 years ago as a branch of Endocrinology and that is now strictly linked to neuroscience. These volumes cover the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine depenedent cancers.

Presents a picture of memory research. This book addresses the major mechanisms by which changes in synaptic strength can persist. It also includes research at the systems level including the importance of changes in inhibitory interneurons and how they play a role in memory formation.

The brain is plastic and it can change its function to adapt to changing demands of various kinds. The brain can also re-organize and change its function to better utilize its resources when parts of the brain have been damaged through injuries and diseases. This means that the brain is not hard wired but can be reprogrammed when needed. This book describes different aspects of how the plasticity can become activated and how it can benefit the individual person. This book provides in-depth coverage of many important aspects of neural plasticity and how it applies to trauma, including strokes and disorders of the central nervous system that affect memory and cognition. The book also discusses how neural plasticity is involved in aphasia, pain and tinnitus. The roles of neural plasticity in motor rehabilitation and in adaptation to prostheses such as cochlear and cochlear nucleus implants are also topics of the book.

Clinical neuropsychology has evolved by integrating neuroanatomical, electrophysiological and psychophysical data, and has led to the development of rehabilitation tools. This volume tries to link the new concepts and discoveries in the field of sensorimotor coordination.

Discusses how the various parts of the brain process and integrate visual signals, providing original findings, reviews, and theoretical proposals on visual processing. This book addresses the basic mechanisms of visual perception as well as issues such as neuronal plasticity, functional reorganization and recovery, and sensory substitution.

Describes the importance of brain temperature and hyperthermia in disease processes. This book presents research on the first observations on Nanoparticles that worsen the outcome of hyperthermia. It discusses the effects of hyperthermia on the blood-brain and blood-cerebrospinal fluid barriers.

Documents developments and research findings in relation to sex and how the brain's function and behavior differs from men to women.

Covers of the role of genetics in many endocrine-related events, like neuroendocrinological diseases and endocrine dependent cancers (prostate, breast, etcetera). This title provides the information on possible treatments of neurodegenerative brain diseases (for example, Alzheimer and similar syndromes).

Focuses on the interplay of mind and motion - the bidirectional link between thought and action. In particular, This book investigates the implications that this coupling has for decision making. How do we anticipate the consequences of choices and how is the brain able to represent these choice options and their potential consequences?

How do we anticipate the consequences of choices and how is the brain able to represent these choice options and their potential consequences? How are different options evaluated and how is a preferred option selected and implemented? This title focuses on the interplay of mind and motion-the bidirectional link between thought and action.