Books in the Progress in Medicinal Chemistry series

This volume covers advances in five areas of pharmacology and medicinal chemistry including an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis.

Presents the research in the field of drug discovery.

This volume features accounts of the biological rationale, design and clinical potential of drug molecules; summaries of structure-activity relationships in topical areas of medicinal chemistry and extensive references to the biology, medicinal chemistry and clinical aspects of each topic.

Published on a twice yearly basis to bring updates in medicinal chemistry, this title presents research in the field of drug discovery.

Spans a wide range of topics of interest to the drug discovery community. This book touches upon the following: the Herg ion channel; fluorescence-based high throughput assay; aprepitant and neurokinin receptors; muscarinic receptor targets; gene activation pathways; malaria and antimalarial drugs; and, HIV virus mutation and new therapeutics.

This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections.

This volume in the series on medicinal chemistry continues to reflect current progress in a broadly developing field by presenting five reviews of mid-to-late-1990s movement in areas such as Alzheimer's disease, chemotherapy, drug transportation, pathogenic microbes and enantiomers.

What defines a quality lead, where these quality leads come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry. This volume addresses these questions and discusses diabetes, obesity and tuberculosis. It presents research in the field of drug discovery.

Progress in Medicinal Chemistry, Volume 59, provides a review of eclectic developments in medicinal G139 chemistry. Each chapter is written by an international board of authors, with this release focusing on Small Molecules - Giant Leaps for Immuno-Oncology, Reviewing P2X7, Reviewing ASK1, and Reviewing DNA-encoded libraries. Provides extended, timely reviews of topics in medicinal chemistryContains targets and technologies relevant to the discovery of tomorrow''s drugsPresents analyses of successful drug discovery programs

Progress in Medicinal Chemistry, Volume 56, provides a review of eclectic developments in medicinal chemistry. This volume includes chapters covering recent advances in cancer therapeutics, fluorine in medicinal chemistry, a perspective on the next generation of antibacterial agents derived by manipulation of natural products, a potential new era for Chagas Disease drug discovery, and imaging in drug development.Extended, timely reviews of topics in medicinal chemistryContains targets and technologies relevant to the discovery of tomorrow''s drugsPresents analyses of successful drug discovery programs

Provides a review of eclectic developments in medicinal chemistry. This volume also provides insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the range of tools now available to solve key scientific problems.

Presents the research in the field of drug discovery.