Books in the Springer Series in Pharmaceutical Statistics series

This book provides an up-to-date review of the general principles of and techniques for confirmatory adaptive designs. This book describes adaptive design methodology at an elementary level, while also considering designing and planning issues as well as methods for analyzing an adaptively planned trial.

This book illustrates numerous statistical practices that are commonly used by medical researchers, but which have severe flaws that may not be obvious.

This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials.