Books in the The Clinics: Internal Medicine series

This issue of the Interventional Cardiology Clinics edited by Michael Lee covers all key aspects of complex coronary intervention. Topics include, but are not limited to: Saphenous Vein Interventions, Atherectomy Devices for the Treatment of Calcified Lesions, Bifurcation Stenting, Chronic Total Occlusion, Multivessel Coronary Artery Disease, Management of Complications (Perforation/Dissection/Thrombosis), Antithrombotic Therapy in Percutaneous Coronary Intervention, and Acute Myocardial Infarction/Thrombectomy.

This issue of Endocrinology and Metabolism Clinics examines the timely topic of Lipidology. In addition to the New Recommendations - ACC/AHA Lipid Guidelines, the issue also includes Familial Hypercholesterolemia; LDL Apheresis; Lipids in Pregnancy and Women; Diabetes and Lipidology; Diabetic Dyslipidemia; Fatty Liver Disease; Lipids and HIV Disease; Residual Risk; and Statins' effects on diabetes, cognition, and liver safety.

This issue of Clinics in Geriatric Medicine, guest edited by Drs. Cynthia Boyd, James T. Pacala, and Michael W. Rich, is devoted to Chronic Conditions in Older Adults with Cardiovascular Disease. Articles in this issue include: Epidemiology of multimorbidity in older adults with cardiovascular disease; Impact of multimorbidity on clinical outcomes in older adults with cardiovascular disease; Assessment of goals of care in patients with multiple chronic conditions; Challenges in decision-making: balancing trade-offs; Multimorbidity in older adults with heart failure; Multimorbidity in older adults with acute coronary syndromes; Multimorbidity in older adults with aortic stenosis; Multimorbidity in older adults with atrial fibrillation;Anticoagulation in older adults with multimorbidity; Approach to evaluating the multimorbid patient with cardiovascular disease undergoing non-cardiac surgery; Integrating care across disciplines; Assessing risks and benefits of invasive cardiac procedures in patients with advanced multimorbidity; Multimorbidity and end of life care in patients with cardiovascular disease; and Future research directions for cardiovascular disease.

Preterm neonates remain at increased risk for adverse bilirubin-related outcomes, including acute bilirubin encephalopathy relative to term infants. Yet, most vulnerable neonates are likely benefit form the potent anti-oxidant properties of bilirubin. Evidence-based guidelines for the management of hyperbilirubinemia in preterm infants, however, are lacking. High concentrations of unconjugated bilirubin can cause permanent neurologic damage in infants, evident through magnetic resonance imaging of chronic bilirubin encephalopathy or kernicterus. There is a growing concern that exposures to even moderate concentrations of bilirubin may lead to subtle but permanent neurodevelopmental impairment referred to as bilirubin-induced neurologic dysfunction. Our current use of phototherapy to decrease bilirubin loads and its potential photo-oxidant properties is a biological conundrum that has been questioned in the use of phototherapy for very low birth weight neonates. In this issue of Clinics in Perinatology, we provide updates on the current understanding of the biology, mechanisms of increasing bilirubin load due to hemolysis, decreased bilirubin binding capacity and glucose-6-phosphate dehydrogenase deficiency, as well as clinical strategies to operationalize the thresholds for hyperbilirubinemia interventions in preterm infants.

This issue of the Surgical Pathology Clinics, edited by Drs. Blaise Clarke and Glenn McCluggage, focuses on Gynecologic Pathology. Topics covered in the issue include, but are not limited to: Gynecologic manifestations of the DICER1 syndrome; Prophylactic gynecologic specimens from hereditary cancer carriers; Lynch syndrome associated endometrial cancer; Peutz-jeghers syndrome associated gynecologic tumors; Gynecologic manifestations of less commonly encountered hereditary syndromes; and Clinical testing for hereditary predisposition.

This issue of Dermatologic Clinics, Guest Edited by Dr. Murad Alam, is devoted to Practice Gaps in Dermatology. Articles in this issue include: Psoriasis and Papulosquamous Disorders; Blistering Diseases; Disorders of the Nails; Disorders of the Hair; Infections; Abnormal Pigmentation; Lupus, Scleroderma, Dermatomyositis; Genodermatoses; Pruritus; Drug Reactions; Dermatoses of Pregnancy; Contact Dermatitis; Acne and Rosacea; Radiation Therapy; Surgery for Skin Cancer; Cosmetic Dermatologic Surgery; Light, Laser and Energy Treatments; and Melanocytic Lesions and Melanoma.

This issue of PET Clinics focuses on PET-Based Molecular Imaging in Evolving Personalized Management Design, and is edited by Drs. Abass Alavi and Sandip Basu. Articles will include: PET-Based Personalized Medicine: An Unavoidable Path for the Foreseeable Future; Personalized Management Approaches in Lymphoma: Help from PET; PET-CT in Head-Neck Malignancies: the Implications for Personalized Clinical Practice; PET Imaging of Skeletal Metastases and its Role in Personalising Further Management; PET-Based Molecular Imaging in Designing a Personalized Management Model in Neuroendocrine Tumors; Personalized Clinical Decision Making in GI Malignancies: Where Can PET Help?; PET in Breast Carcinoma: Can it Aid in Developing a Personalized Treatment Design; PET and Thyroid Cancer: Can it Help in Evolving a Personalized Treatment Design?; PET Imaging Towards Individualized Management of Urological and Gynaecological Malignancies; The Possible Role of PET Imaging towards Individualized Management of Bone and Soft Tissue Malignancies; PET-Based Personalized Management of Inflammatory Disorders; PET-Based Radiation Oncology; PET-Based Interventional Radiology; The Current and Evolving Role of PET in Personalized Management of Lung Carcinoma, and more!

This issue of Emergency Medicine Clinics focuses on Geriatric Emergencies. Articles include: Recent Trends in Geriatric Emergency Medicine, Resuscitation of the Elderly, Pharmacology in the Geriatric Patient, Trauma and Falls in the Elderly, Sepsis and Infectious Emergencies in the Elderly, Evaluation of the Geriatric Patient with Chest Pain, Evaluation of Dyspnea in the Elderly, Abdominal Pain in the Geriatric Patient, Neurologic Emergencies in the Elderly, Evaluation of Syncope, Altered Mental Status and Delirium, and more!

Alcohol abuse remains a significant problem world-wide. The most commonly affected organ remains the liver with a risk of alcoholic liver disease (ALD) which can range from asymptomatic to alcoholic hepatitis to alcoholic cirrhosis. In 2010, alcohol-attributable cirrhosis was responsible for 0.9% of all global deaths. Given the sheer magnitude of alcohol abuse and alcoholic liver disease, an update on this topic is pertinent and relevant. This issue will focus on a variety of topics including alcoholism, the pathogenesis of ALD, the spectrum of ALD, the pathology of ALD, and the long-term management of patients with ALD. Alcoholic hepatitis is a particular type of ALD with a high mortality. This issue will explore the syndrome of alcoholic hepatitis, its prognostic markers, and the available therapies. Because alcohol intake can influence so many other conditions of the liver (especially hepatitis C), articles in this issue will also explore the impact of alcohol abuse on other liver conditions. In addition, several other topics such as nutritional therapy for ALD, ALD and liver cancer, and ALD and infection risk will be explored. Also, even though it is quite controversial, we will also explore liver transplant as a therapy for alcoholic liver disease including alcoholic hepatitis.

Drs. Robert Kotloff and Francis McCormack have assembled an expert team of authors on the topic of Rare and Orphan Lung Diseases. Articles include: Lymphangioleiomyomatosis, Pulmonary Lymphangiomatosis, Langerhans Cell Histiocytosis and other Histiocytic Diseases of the Lung, Pulmonary Alveolar Proteinosis, Pulmonary Alveolar Microlithiasis, Primary Ciliary Dyskinesia, Birt-Hogg-Dube Syndrome, Hermansky-Pudlak Syndrome, Hereditary Hemorrhagic Telangiectasia, Non-CF Bronchiectasis, Eosinophilic Lung Diseases, Benign Metastasizing Leiomyomata, and more!

This issue of Endocrinology and Metabolism Clinics, guest edited by Drs. Caroline M. Apovian and Nawfal Istfan, is devoted to Obesity. Articles in this comprehensive issue include: Guidelines for Obesity Management; Obesity is a Disease; Pharmacotherapy for Obesity; Bariatric Surgery Mechanisms; Diabetes Treatment in the Patient with Obesity; Adipose Tissue: Inflammation and the Endocrine Organ; Behavioral Treatment of the Patient with Obesity; The Role of Macronutrient Content in the Diet for Weight Loss and Weight Maintenance; Substrate Oxidation and Brown Adipose Tissue; Brown and Beige Adipose Tissue: Therapy for Obesity?; Ethnic Differences in Diabetes Lipids HTN and Obesity; Genetics of Bariatric Surgery Outcomes; Leptin and Hormones: Energy Homeostatis; Bariatric Surgery Clinical Outcomes; Medical Devices for Obesity; Adolescent Bariatric Surgery; Psychological Aspects of Obesity; and Nutrient Timing.

This issue of the Clinics in Laboratory Medicine on "Pharmacogenomics” is being edited by Drs. Roland Valdes and Kristen Reynolds and will cover a wide variety of topics, including but not limited to, fundamentals of pharmacology, a review of pharmacogenetics guidelines, pharmacogenetic testing in pain management, pharmacogenetics of pain management, clinical and economic impact of pharmacogenetic genotyping analysis, exosome analysis in lab medicine, and implementation of pharmacogenetics in developing countries.

This issue of Primary Care: Clinics in Office Practice, guest edited by Dr. Michael Malone, is devoted to Allergy Primer for Primary Care. Articles in this issue include: Indoor and Outdoor Allergies; Food Allergies; Insect Allergy; Drug Allergy; Allergic Dermatoses; Allergic Rhinitis; Respiratory Allergic Disorders; Eosinophilic Gastrointestinal Disorders; Mastocytosis; Allergy Testing; Allergy Immunotherapy; Anaphylaxis; and Complementary and Alternative Treatment for Allergic Conditions.

This issue of Sleep Medicine Clinics focuses on Ambulatory Sleep Medicine. Article topics include: Diagnosis of Obstructive Sleep Apnea; Personalised medicine for Obstructive Sleep Apnea therapies: Are we there yet?, Cardiovascular risk of Obstructive Sleep Apnea; Motor Vehicle Accident risk related to Obstructive Sleep Apnea; Impact of Obstructive Sleep Apnea Syndrome on Neurocognitive function and impact of CPAP; CPAP therapy for Obstructive Sleep Apnea; Maximizing adherence including using novel IT based systems; Mandibular advancement splints; Surgical approaches to Obstructive Sleep Apnea; Consequences of Obstructive Sleep Apnea; and more!

This issue of the Child and Adolescent Psychiatric Clinics will be Part II of II on Substance Use Disorders. Part II will be edited by Drs. Ray Hsiao and Paula Riggs. This portion will focus more on treatments, recovery, and support considerations for adolescents with substance abuse issues. Topics covered include, but are not limited to: screening brief intervention referral treatment in primary care, family-based interventions, motivational enhancement therapy, school-based interventions, contingency management, pharmacotherapy, treatment for children with co-morbid psychiatric issues, special populations, and integration of system of care.

Pediatricians care for children and families from all walks of life. Some are children known from neighborhoods. Others are children from distant lands. Pediatric focus does not stop with the physical care of children but extends to include their mental and social-emotional health and concern about their families. Pediatricians care about how children are doing at home, at school, and in their communities. In this era, children and their families are impacted by social and political changes in their homes (social media and screen time), in their communities (refugee populations and children requiring palliative supports at school), in their health care networks (EMR in every tertiary pediatric center), and in the larger world (multiple military deployments of fathers and mothers). This issue explores the impact of contemporary public health challenges for pediatric care, promising models for caring for chronically ill children, and state of the art therapies for complex childhood conditions.

This issue of Cardiology Clinics on Sports Cardiology, edited by Drs. Aaron Baggish and Andre La Gerche, will cover a variety of aspects related to cardiovascular health and complications related to athletic activity. Topics covered in this issue include, but are not limited to, molecular aspects of exercise-induced cardiac remodeling; sudden cardiac death; atrial fibrillation in endurance athletes; congenital heart disease in athletes; exercise prescription for the athlete with cardiomyopathy; and advanced exercise testing for the sports cardiologist.

This issue of Endocrinology and Metabolism Clinics, guest edited by Dr. Sethu K. Reddy, is devoted to Diabetes. Articles in this issue include: Approach to Multicultural Issues in Diabetes; Clinical Utility of Genetic Testing in T2DM; Utility of CGM - Type 1 and Type 2 Diabetes Mellitus; Islet Cell Transplantation; Use of Telemedicine; Nonalcoholic Steatohepatitis; Microbiome: Role in Type 1 and Type 2 Diabetes Mellitus; Population Management and Diabetes; Pre-diabetes; Metformin: What do we know?; Insulin: Making Sense of Current Options; Nutrition in Diabetes; Bariatric Surgery: Pathophysiology and Outcomes; Future Therapies in Diabetes; Lipodystrophic Syndromes; and In-patient Diabetes Management in the 21st Century.

Despite advances in medical technology and patient safety initiatives, maternal morbidity and mortality rates continue to increase. Maternal mortality trends in the US as reported from the CDC from 1989-2009 demonstrate increasing mortality trends from 7.2 deaths per 100,000 live births in 1987 to 17.8 deaths per 100,000 live births in 2009. To combat this problem, a thorough understanding of the critical medical and surgical issues that are often encountered in pregnancy is essential. Each article addresses a topic relevant to care of the critically ill gravida.

The Guest Editors of this issue have come together with the goal of producing a useful, basic guide on this population for pediatric primary care clinicians. Topics in this issue address: Caring for LGBT Youth & Families in Inclusive and Affirmative Environments; Mental Health and the Development of Sexual Orientation and Gender in Children and Adolescents; What the Primary care Pediatrician Needs to Know about Gender Variance in Children and Adolescents; Clinical Implications of Stigma, Minority Stress, and Resilience as Predictors of Health and Mental Health Outcomes; LGBT Youth and Bullying; LGBT Youth and Family Acceptance; HIV, Other Sexually Transmitted Infections, and Sexual Health in LGBT Youth; Substance Abuse Prevention, Assessment & Treatment for LGBT Youth; Body Image and Disordered Eating among LGBT Youth; and Sociocultural Factors and LGBT Youth''s Health-related behavior. Pediatricians will come away with a solid understanding of recognizing and communicating with LGBT children and adolescents.

This issue of Psychiatric Clinics, edited by Dr. James Knoll, is dedicated to violence and the psychological ramifications of violence in a wide array of situations. Subjects covered include, but are not limited to, violence by parents against children; gender and violence; lone wolf terrorists; inpatient violence; neuroimaging violence; workplace violence; gun violence; the military perspective on violence; homicides; suicides; sex offender risk and management; and psychopharmacology.

This issue of Medical Clinics, guest edited by Dr. Edward Frohlich, is devoted to Hypertension. Articles in this outstanding issue include The Kidney in Hypertension; Heart: Fibrosis, Apoptosis, and Cardiac Failure; Myocardial Ischemia; Oxidative Stress and Hypertensive Diseases; Adherence to Antihypertensive Therapy; Aging and Hypertension; Target Organs and Microbiological Considerations in Hypertensive Diseases; Obesity and Sodium Considerations; Diabetes, Hypertension and Cardiorenal Syndrome; Renal Arterial Disease; Cardiac Transplantation and Hypertensive Diseases; Cardiac Failure: Old and New Challenges; Diastolic Dysfunction and Hypertension; Stiffening of Large Arteries; Genetics and Mechanisms; New Guidelines for Hypertensive Diseases; and Local Renin Angiotensin Systems.

Dr. Quigley has created a must-have reference on the gut microbiome for the practicing gastroenterologist. A leader in the field of human physiology and digestive disorders, he has laid out the basics on this increasingly important topic, devoting articles to the organization and biology of the human gut microbiome as well as its diagnostic potential. Top international authors have presented articles that discuss the intersection of the gut microbiome and diet and the gut-brain axis. Clinical implications of the gut microbiome are discussed with disease states like IBD, GI cancer, and liver diseases. Finally, the issue ends with the cutting-edge clinical innovation of fecal microbial transplantation. This issue bridges the gap between science and clinical practice and should be an important reference to practicing gastroenterologists.

Dr. Mimouni and Dr. Koletzko have assembled some of the world''s leaders on breast milk for preterm infants to provide a current overview of the benefits and barriers. Authors address the following  topics: Preterm human milk macronutrient composition; Bed-side human milk analysis in the NICU; Human milk fortification; DHA supplements; Potential benefits of bioactive proteins in human milk for preterm infants; New insights into variations of metabolite and hormone contents in human milk; Immune properties of human milk in relation to preterm infant feeding; Human milk oligosaccharides; Treatment and quality of banked human milk; Use of donor milk: collection, storage and safety; Postnatal CMV infection through human milk in preterm infants: Transmission, clinical presentation, and prevention; NEC and human milk feeding; Neurodevelopmental outcomes of preterm infants fed human milk; Evidence-based methods that promote human milk feeding of preterm infants; and Human flavor learning: the breastfeeding experience. Lactiation consultants, NICU nurses, and neonatologists will find these clinical review articles to be very valuable.

This issue of Primary Care: Clinics in Office Practice, guest edited by Drs. Vincent Morelli, Roger Zoorob, and Joel J. Heidelbaugh, is devoted to Primary Care of the Medically Underserved. This outstanding issue includes the following articles: Primary Care Issues in Rural Populations; Primary Care Issues in Inner City America and Internationally; Medical Care for Undocumented Immigrants: National and International Issues; Pediatric and Adolescent Issues in Underserved Populations; Women''s Health issues in Underserved Populations; Geriatric Care Issues: American and International Perspectives; Medical Care of the Homeless: An American and International Issue; Cardiovascular Issues in the Underserved; Occupational Health and Sleep Issues in Underserved Populations; Infectious Diseases Issues in Underserved Populations; Cancer in the Underserved; Psychological Issues in Underserved Populations; Substance Abuse Issues Amongst the Underserved: American and International Perspectives; Diet and Obesity Issues in the Underserved; Exercise/Sports Medicine Issues in Underserved Populations; A Global Perspective on Climate Change and Health in Underserved Populations; and International Comparisons in Underserved Health: Issues, Policies, Needs and Projections.

This issue of Cardiac Electrophysiology Clinics, edited by Drs. Ravi Mandapati, Kalyanam Shivkumar, and Seshadri Balaji, will cover the latest in Cardiac Arrhythmias in Adults with Congenital Heart Disease. Topics covered in this issue include, but are not limited to Brady arrhythmia; Supraventricular Tachycardia in Adult Congenital Heart Disease; Atrial defects, Ebsteins; Drug therapy; Devices; and Surgery.

This issue of Critical Care Clinics focuses on Psychiatric Aspects of Critical Care Medicine. Editor Jose Maldonado has assembled an expert team of authors on topics such as: Psychiatric Aspects of Organ Transplantation in Critical Care; Medical Complications of Psychiatric Treatment; Psychiatric and Palliative Care in the ICU; Psychiatric Aspects of Heart and Lung Disease in Critical Care; Alcohol Withdrawal Syndromes: Assessment and Management; Substance Abuse and Withdrawal in the Critical Care Setting; Mood Disorders and The Outcome of Suicidal Thoughts and Attempts; Anxiety Disorders and the Outcomes of Trauma; Assessment and Management of Toxidromes in the Critical Care Unit; Neuropsychiatric Consequences of Trauma and Head Injury; Detection and Management of Pre-Existing Cognitive Impairment in the Critical Care Unit; Delirium: Pathophysiology, Diagnosis and Treatment; Neuropsychiatric Aspects of Infectious Processes.

The Guest Editors, coming from the Critical Care Medicine Department in the NIH, are the top thought leaders in the area of infections in critical care. Their topic selections in this issue reflect the most clinically relevant and current information. The issue specifically covers the following topics: Catheter-related bloodstream infections: special considerations in diagnosis in the ICU; Sepsis-How does the new definition help clinicians; Therapeutic drug monitoring of antibiotics; High containment pathogen preparation; Multidrug resistant gram negative infections and enterococcus; Strategies to prevent transmission of resistant organisms; Antibiotic Stewardship: What the intensivist should know; C. Difficile infection in the ICU; Immunocompromised critically ill; Rapid diagnostics: The use of procalcitonin; Respiratory viruses in the ICU: Significance of rhino/rsv updates/adenovirus metapneumovirus; Management of invasive fungal disease in the ICU; Inhaled/Nebulized antibiotics. Infectious disease physicians and intensivists will be armed with the information they need to diagnose and treat patients with infections in the ICU.

This issue of Endocrinology and Metabolism Clinics, guest edited by Drs. J. Chris Gallagher and Daniel Bikle, is devoted to Vitamin D. Articles in this issue include: The Molecular and Cellular Mechanisms of Action of Vitamin D, Worldwide Review of Serum 25OHD Status; RDA Update (7 Years Post IOM); The Use of Vitamin D Metabolites and Analogs in the Treatment of Chronic Kidney Disease; Effect of Vitamin D on Falls and Physical Performance; Vitamin D Effect on BMD and Fractures; Bariatric Surgery and Vitamin D Metabolism, Role of Vitamin D in the Prevention and Treatment of Cancer; Role of Vitamin D in Cardiovascular Disease; Regulation of Immune Function by Vitamin D and its Use in Diseases of Immunity; Genetic Diseases of Vitamin D Metabolizing Enzymes; Measurement of Vitamin D Metabolites: Clinical Issues; The Free 25OHD Hypothesis, and Ethnic/Racial Differences in Vitamin D Levels: Physiologic or Pathologic.

This timely issue of Child and Adolescent Psychiatric Clinics, edited by Drs. Paul Weigle and Kristopher Kaliebe will focus on Internet Habits and Youth Mental Health. Topics discussed in the volume include, but are not limited to: Creation of a family media plan: how tech affects family dynamics and family therapy; Interplay between media habits and development from preschool through adolescence; Interplay between Autism and media habits; Interplay between Depression and media habits including online expression of suicidality and cutting; Interplay between Behaviorally disordered youth and media habits, including violent VG, cyberbullying; Eating disorders, obesity and online engagement; Internet Gaming Disorder (and tech addictions) Treatment; Sexting and online pornography engagement; Interplay between disadvantaged, gender non-conforming and minority youth and media habits; and Media sub-cultures and their intersection with mental illness.