Books in the The Clinics: Internal Medicine series

In collaboration with the Consulting Editors, Ranjan K. Thakur and Andrea Natale, Drs. David R. Holmes Jr., Saibal Kar, Dhanunjaya Lakkireddy, and Vivek Reddy have assembled an issue of Cardiac Electrophysiology Clinics on Left Atrial Appendage. Topics include, but are not limited to, why we have an atrial appendage, thromboembolism in AF, role of LAA in systemic homeostasis, history of LAA closure, impact of LAA closure on systemic thromboembolization, perirprocedural imaging, anatomical considerations for epicardial and endocardial appendage closure, epicardial vs endocardial closure, technical considerations of endocardial and epicardial closure, surgical LAA occlusion, post procedural management, AF patients undergoing ablation, and more.

For this important and unique issue of Gastroenterology Clinics, Consulting Editor Dr. Alan Buchman decided to serve as co-Guest Editor with Dr. David Hackam to provide a "bench to bedside” look at intestinal failure. Authors have contributed reviews on the status of the science behind artificial organs while emphasizing how to clinically prepare for intestinal failure. Articles are devoted to the following topics: Initial Evaluation and Care of the Patient with New Onset Intestinal Failure; Getting the Patient Ready for Home Parenteral Nutrition; Pediatric Intestinal Failure:  Etiology and Management; Predictors of Intestinal Adaptation in Children; Management of the Patient with Chronic Intestinal Pseudo-obstruction and Intestinal Failure; Intestinal Growth and Adaptation Following Resection in Intestinal Failure; Fluid and Electrolyte Management and Prevention of Dehydration in Intestinal Failure; The Oley Foundation and Consumer Support Groups; Weaning from Parenteral Nutrition; Hepatobiliary Complications of Intestinal Failure; Non-Transplant Surgery in Intestinal Failure; Indications for Intestinal Transplantation in Intestinal Failure; Intestinal Regeneration and the Artificial Gut; Bench to Bedside Approaches for Engineered Intestine, Esophagus and Colon; and Fetal and Amniotic Stem Cells in Gut Engineering. Readers will come away with a true state-of-the-art look at how to manage intestinal failure.

This issue of Critical Care Clinics, guest edited by Drs. Hernando Gomez Danies and Joseph Carcillo, focuses on Coagulation/Endothelial Dysfunction. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Cell-cell communication breakdown and endothelial dysfunction; Role of the Tie2/Angiopoetin pathway in endothelial dysfunction; The Glycocalyx; Platelet activation and endothelial dysfunction; Role of antithrombin III and tissue factor pathway; Red blood cell dysfunction; Microvascular hemodynamics, autoregulation and mechanotransduction control of blood flow distribution; Nitric oxide and endothelial dysfunction; Microvascular dysfunction; Hemolytic Uremic Syndrome and atypical HUS; Thrombotic thrombocytopenic purpura, Heparin induced thrombocytopenia and Disseminated intravascular coagulation in the critically ill; Thrombocytopenia associated multiple organ failure (TAMOF); Meningococcemia; Immune consequences of endothelial dysfunction during sepsis; Therapeutic targets in thrombotic microangiopathies with a focus on endothelial disorders; and Coagulation disorders in HLH/Macrophage activation syndrome.

Approx.240 pages

Presents articles that deals with therapies for treatment of HCV. This title addresses such novel therapies as interferons, viral kinetics and anti-viral resistance, anti-fibrotics, immunotherapeutics, hepatoprotectants and caspace inhibitors, and cyclosporine analogues.

Addresses movement disorders. This title contains the following articles: Etiogenesis of Parkinson's Disease; Medical Treatment of Parkinson's Disease; Surgical Treatment of Movement Disorders; Tremor: Clinical Features, Pathophysiology and Treatment; Dystonia - Genetics and Treatment; and, Huntington's Disease and Other Choreas.

Aging is associated with an increased prevalence of several GI disorders, including those induced by drugs (such as gastrointestinal bleeding caused by nonsteroidal anti-inflammatory drugs), anorexia of aging, development of constipation, diarrhea or fecal incontinence, and postprandial hypotension. This book addresses these disorders.

Addresses the full spectrum of food allergies in children. Of interest to pediatricians, this title begins with the clinical presentation and epidemiology of food allergy, and then progresses to the diagnostic testing and pahthophysiology. It deals with specific types of food allergy, dairy, soy, egg, peanut, and tree nut.

Contains topics that include regulatory T cells as key players in tolerance and autoimmunity, and immunology lessons from monogenic conditions such as AIRE. This book also covers immunogenetics of T1D and AITD; advances in T1D therapeutics, including islet cell replacement and salvage; and TSHR structure and function.

Circadian rhythm sleep disorders are caused by a mismatch between the sleep - wake pattern and circadian phase. Sleep at the circadian high is impaired, while alertness is reduced during wakefulness. This book discusses consequences of circadian disruption in animal models, and influence of circadian system on disease severity.

Offers insights on how to handle the following situations: emergency and urgent surgery; perioperative management of the ambulatory surgery patient; perioperative anticoagulation management; surgery in the patient with liver disease; surgery in the patient with renal dysfunction; and, hematological problems in the preoperative patient.

Although choledocholithiasis is the most common reason for endoscopic treatment, other indications include pancreatolithiasis, cholangitis, biliary pancreatitis, papillary stenosis, sphincter of Oddi dysfunction, and benign or malignant ductal strictures. This book presents information on biliary and pancreatic endoscopy procedures and techniques.

Discusses some of the challenging aspects of diagnosis and treatment of inflammatory bowel disease. This title places emphasis on comparing treatment paradigms, biologics agents, safety profile of therapeutics, and novel diagnostic and prognostic tools for IBD.

Focuses on what the endocrinologist needs to know about sports and doping, and provides the most up-to-date information. Topics covered in this title include growth hormone, insulin-like growth factor, anabolics, urine testing, Beta-2 agonists, stimulants, glucocortiocoids, and dehydroepiandrosterone (DHEA).

Respiratory infections are among the most common causes of morbidity and mortality worldwide. These infections present a special challenge to physicians for several reasons, including disasters caused by severe acute respiratory syndrome (SARS) and bird and swine influenza.

Divided into two sections as Varied BSM Targets and The Insomnias, this title covers topics such as CPAP Compliance, Periodic Leg Movement Disorder and Restless Legs Syndrome, Circadian Rhythm Disorders, Cognitive Mechanisms in Insomnia, Physiological Mechanisms in Insomnia, Primary Insomnia, Comorbid Insomnia, and Hypnotic-Dependent Insomnia.

Often the hepatologist sees patients in consultation. This book focuses on how to deal with diagnosing, treating, and managing patients in the hospital on a consultation basis. It presents articles on the asymptomatic outpatient with abnormal LFTs, and surgery in the patient with liver disease.

In Sleep medicine, as in most disciplines, understanding of epidemiology plays a crucial role in clinical treatment of sleep disorders. This book discusses several epidemiologic studies with a specific focus on the clinical implications of the findings.

An ulcer is an open sore in the lining of the stomach or intestine. Peptic ulcers are eventually caused by acid and pepsin, a digestive stomach enzyme. This book presents an overview of the causes, diagnosis, and treatments of peptic ulcers, including conditions like Zollinger-Ellison syndrome.

Offers the practicing clinician concepts and management of hypertensive disease. This book contains topics that include risks in hypertension; biological concepts of target organ involvement in hypertension; hypertension and the metabolic syndrome; aging versus hypertension; and hypertension, systolic blood pressure, and large arteries.

Discusses Infant Development. This title includes two articles on assessment in early childhood psychiatry: Psychiatric assessment, and Assessment of the caregiver-child relationship in early childhood psychiatry. It also discusses Early Childhood Mental Health Problems, such as Internalizing, Trauma and PTSD, and Preschool Disruptive Behavior.

Tackles the legal issues that are faced by doctors. This title covers topics that include: Clinical Practice Guidelines; the Legal Process - Being a Defendant or an Expert Witness; Professional Liability Insurance; Informed Consent, AMA, Refusal of Care, Capacity; CQI, Incident Reports, Reporting Requirements, PEER Review; and, more.

Covering fetal neurology, this title explores the genetic basis of normal brain development and its disorders, including reviews on the prosencephalon, the cerebral cortex, and the cerebellum. It includes articles on normal fetal cerebral substrate supply, disorders of placental circulation and the fetal brain, and disorders of fetal circulation.

Vasectomy is the most commonly utilized form of male contraception. This title addresses the issues in such a way to allow the reader to evaluate what works best for their individual practice utilizing evidence-based medicine when it exists.

Biomarkers may be enzymes, hormones, biologic substances, or other markers of cardiac stress and malfunction which appear to have growing importance in heart failure. Many biomarkers appear to provide information about the cause of heart failure. This book discusses the role of biomarkers and includes articles that explore individual biomarkers.

A review of both the genetic and genomic factors resulting in a predisposition to human cancer. It includes articles addressing predisposition syndromes in the areas of breast cancer, lower GI cancer, genitourinary cancer, pediatric cancer, endocrine cancer, and hematologic malignancy.

Deals with the topic of endocrine-adrenal and steroid hypertension. In this title, the following topics are covered: an overview of endocrine systems and hypertension; accuracy and cost effectiveness of screening for adrenal-endocrine hypertension; and pheochromocytoma and related chromaffin cell tumors in adreno-medullary disease.

Reviews sleep in children and adolescents. This title focuses on topics such as: Evaluating sleep and sleep disorders in the pediatric primary care setting, insomnia, sleep-disordered breathing, Restless legs syndrome and periodic limb movement disorder, Circadian rhythm disorders, Sleep in adolescents: the perfect storm, and Sleep in the family.

Arrhythmogenic right ventricular dysplasia is an inherited heart muscle disorder that may cause abnormal electrical heart rhythms and weakening of the pumping action of the heart, resulting in sudden death.