Books in the Wiley Series in Drug Discovery and Development series

Kinase Inhibitor Drugs covers a wide and comprehensive range of topics about kinase-targeted inhibitors in cancer therapy, one of the hottest drug targets in modern drug discovery.

HYDROGEN SULFIDECovers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applicationsResearch on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H2S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H2S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities.Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation required for understanding the fundamental chemical biology of H2S while highlighting the compound's therapeutic potential and medicinal applications. This book covers key aspects of H2S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H2S in biological environments; and the therapeutic and medicinal uses of exogenous H2S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field.* Provides approaches for delivering H2S with relevance to biological and therapeutic applications* Describes complex interactions of H2S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species* Summarizes advances in available tools to detect, measure, and modulate H2S levels in biological environments, such as real-time methods for H2S fluorescence imaging in live cell and animal systems* Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action* Includes in-depth case studies of different systems in which H2S plays an important roleHydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.

Chemosensors?organic molecules designed to bind and sense small molecules or metal ions?function as molecular-level sensors that generate a signal upon binding.

Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference.

Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, this book overviews plant biodiversity as a source of new drugs and drug discovery strategies.

This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage.

Understanding bioavailability is critical to determining the amount of a drug to administer.

This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents.

This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery.

Explaining the assessment of potential drug compounds, this is an ideal introductory reference for those new to drug discovery. It includes sections on pharmacokinetics and drug metabolism, integration of pharmaceutical development, and predictive safety assessment.

Covering all areas of the medicinal chemistry and therapeutic applications of nucleic acids, this book provides up-to-date coverage of the broad area of nucleic acid chemistry and biology.

Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market.

Both a reference source for researchers and a text for graduate students investigating the various aspects of the dopamine transporter (DAT), Dopamine Transporter: Chemistry, Biology, and Pharmacology includes aspects of chemistry, biology, and pharmacology and provides a strong general overview of this neurotransmitter.

GSK-3 is a promising drug target that has been extensively tested, and shown great potential for treatment of diseases that have no current effective treatment - like Alzheimer's, bipolar disorder, and cancer.

Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention.

This book gathers present knowledge on the involvement of ABC transporters in drug transport and resistance. Bringing together updated information from an otherwise-scattered field of scientific literature, this resource helps researchers in pharmaceutical science in discovering drugs able to counteract multidrug resistance in diseases like cancer.

Studies of vaccines derived from carbohydrate antigens have seen great progress. Synthetic carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids, have been explored or used to prevent and treat bacterial and viral infections, cancer, and other diseases.

Computer Applications in Pharmaceutical Research and Development analyzes the use of computers through the entire pharmaceutical process of discovering, developing, and marketing new medicines.

This book focuses on the formulation and delivery of dendrimers. It offers both a comprehensive introduction and reference to practical applications. The coverage encompasses dendritic drug delivery systems ranging from dendrimers chemistry to cellular uptake of dendritic nanoparticles.