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Synthèse des meilleurs outils du coaching pour le manager, ce livre pratique traite les différents aspects du coaching-management en suivant le processus d'un accompagnement de coaching. Il modélise pour vous, l'attitude de coach. Il vous apporte les compétences opérationnelles qui répondent à vos besoins concrets de manager au quotidien: Relationnel, communication, délégation, traitement des situations et des personnes difficiles, prise de décision, motivation. Cette troisième édition est actualisée et enrichie. En plus d'un chapitre consacré au burn-out (conditions, prévention), il inclut un chapitre dédié au management Agile (raison d'être, atouts et pratique). Que vous vouliez être manager-coach (éclairé et performant), devenir coach, éviter le burn-out ou devenir Agile), ce livre vous apporte les techniques et les savoir-faire pour y parvenir le plus facilement possible. Simplement, pas à pas, tout en vous fournissant une vraie richesse de contenu, de savoir, de savoir-faire et aussi, sur la durée, de savoir-être

This book introduces personalized immunotherapy with multi-dimensional models of analysis to determine the best plan for immunotherapy of patients. The book introduces readers to some basic concepts which lay the foundation for personalized immunotherapy: the development of a major histocompatibility complex (MHC), the genome profile of T cells and tumor cells, and genome-wide association studies. Chapters also cover special topics such as new immunoassay methods related to personalized immunotherapy and targeted immunotherapy which are geared towards familiarizing readers with current research practices. Focusing on the central theme of personalized immunotherapy, the authors provide a wealth of information about T-cell screening, tumor neoantigen cloning, primary tumor cell culture for T-cell cloning, bioinformatics strategies for understanding T-cell and primary tumor cell biology and function, and new developments in research on adoptive T-cell immunotherapy. These developments include T-cell gene therapy and T-cell gene editing, transgenic T-cells for increasing affinity to tumor cells such as CAR T-cells and TCR T-cells, and the systematic modeling of polyclonal specific T-cells and biobank technology.Key Features: - Introduces readers to basic concepts in personalized medicine and immunotherapy- Presents current information about immunological assays used in research- Presents an overview of T cell immunotherapy and cloning techniques- Presents an overview of tumor cell bioinformatics and its role in immunotherapy- Includes new developments and references for personalized immunotherapy techniques (T-cell gene therapy and T-cell gene editing, transgenic T-cells which target CAR T-cells and TCR T-cells, and polyclonal T-cell modeling)- Includes a section on biobanking- Presents information in an easy-to-read format for a wide range of readers- Brings contributions from experts with over 30 years of experience in personalized immunotherapyPersonalized Immunotherapy for Tumor Diseases and Beyond is an ideal handbook for medical professionals and students involved in personalized medicine, immunology and oncology. General readers interested in the new developments in these fields will also benefit from the information provided.

For decades, scientific efforts have been made to understand obesity and related diseases such as type 2 diabetes and neurodegeneration, and their link with meta-inflammation. Adipose tissue is, at present, viewed as an endocrine organ with important biological effects on metabolism and inflammation, with a possible role in the pathogenesis of obesity-associated metabolic and inflammatory diseases. In view of the fact that the role of chronic systemic low-grade inflammation has gained significant attention as the key player in the pathophysiology of obesity- and aging associated diseases, Meta-Inflammation and Obesity offers readers state-of-the-art knowledge on this subject. Chapters cover special topics such as gender differences in obesity-related type 2 diabetes as the consequence of inflammatory response, insights into metabolic changes caused by excessive adipose tissue (which lead to abnormal brain metabolism, neuroinflammation, cognitive decline, development of type 3 diabetes), and the importance of inflammaging in the aging process. Graduate, postgraduate and Ph. D. candidates in medicine, pharmacy, and students of applied medicine, health care professionals as well as scientists involved in adipose tissue research, meta-inflammation analysis, obesity-related medical specialties will find this book a useful reference on the link between inflammation and obesity.

Heat Stress In Food Grain Crops: Plant Breeding and Omics Research is a timely compilation of advanced research on heat stress affecting crop yield, plant growth & development of common food grain and cereal crops. Chapters in the book cover several aspects of crop science including the identification of potential gene donors for heat tolerance, physiological mechanisms of adaptation to heat stress, the use of conventional and modern tools of breeding for imparting tolerance against terminal temperature stress and precise mapping of heat tolerant QTLs through biparental and genome wide association mapping. The use of genomics and phenomics methods is focused on through chapters dedicated to important crops such as groundnut, pearl millet, maize, chickpea, mungbean and wheat. Authors of the respective chapters explain the importance of harnessing a diverse crop genepool for sustaining crop production under conditions of increasing heat stress. Readers will be able to understand the relevance of functional genomics in elucidating candidate genes and their regulatory functions contributing to heat tolerance.

This reference presents reviews and case studies of hazardous waste management in a selection of cities. The overarching themes of the compiled topics include 1) the problems of healthcare waste management, 2) case studies of hazardous waste mismanagement, 3) health risks associated with environmental waste, issues in environmental health and 4) grassroots environmentalism.The volume initially presents reviews and case studies from developing countries, including countries in South America (Argentina), Africa (Algeria and Nigeria), and Asia (India). The latter chapters of the book focus on environmental issues in Campania, a region in Italy. These chapters also provide an insight into the impact of the COVID-19 pandemic on waste management practices in this region.Risks and Challenges of Hazardous Waste Management is an insightful reference for management trainees, professionals and researchers associated with waste management and environmental health firms. Readers will gain insights into current issues and practices in the respective industries. The reviews and case studies presented in the reference are also useful to professionals involved in risk assessment studies.

This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The eighth volume of this series features 8 chapters that cover methods for antimicrobial drug discovery (with 2 chapters that focus on genomics) as well as updates on drug development against Helicobacter pylori and emerging coronaviruses, among other interesting topics: - Eradication of Helicobacter pylori Infection with Non-Bismuth Quadruple Concomitant Therapy - Drug Discovery Strategies Against Emerging Coronaviruses: A Global Threat - Opportunities Offered By Fragment-Based Drug Design in Antibiotic Development - Phage therapy as a Tool for Control of Foodborne Diseases: Advantages and Limitations - Subtractive Genomics Approaches: Towards Anti-Bacterial Drug Discovery - Recent Advances in the Discovery of Antimicrobials through Metagenomics - Phyto-Nano-Antimicrobials: Synthesis, Characterization, Discovery, and Advances - Aptamers as Anti-infective Agents

Biosensing technology is rapidly flourishing in recent years due to the advancement of bio-MEMS/NEMS. However, the booming development of biosensors has not been very well addressed to the unmet clinical needs. Advances in Biosensing Technology for Medical Diagnosis initiates a headway into the realm of cutting-edge diagnostic tools which are expected to become routine clinical practice. This book aims to broaden the readers' horizon and guide them in tailoring different biosensing techniques for specific diagnostic procedures. Key Features: - 12 chapters cover several aspects of biosensing technologies including working principles and clinical validations - highlights the state-of-the-art biosensing technology developed in all fields - provides information about specific applications of novel biosensors used in clinical diagnosis, - provides step-by-step guidance of microfabrication for biosensors - focuses on bridging the gap between the scientific and the clinical communities - provides information about the diagnostic applications of biosensors for different diseases (including infectious diseases and neurodegenerative diseases). - covers Information about unconventional nano/microfluidic biosensor systems - features contributions from renowned experts in the field of biomedical engineering Advances in Biosensing Technology for Medical Diagnosis serves as a reference for healthcare providers and biomedical engineers who are interesting in biosensing techniques in medicine. The information provided in this reference will also benefit healthcare policymakers who are interested in new technologies that can impact the delivery of diagnostic services in healthcare systems.

Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.

Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture. The eighth volume of the series features six reviews focusing on NMR spectroscopic techniques in food science, molecular biology and medical diagnosis. The reviews in this volume are: - qNMR as a Tool for Determination of Six Common Sugars in Foods - Correlation of VIP Scores and 1H NMR to Extract Information of Psychological Attention Tests Applied Before and After Coffee Intake - NMR Spectroscopy for Probing the Structural Determinants of Aptamer Optimization and Riboswitch Engineering - Applications of NMR Spectroscopy in Medical Diagnosis - Applications of NMR Spectroscopy in Cancer Diagnosis - NMR as a Tool for Exploring Protein Interactions and Dynamics

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. The fifth volume of the series covers the following topics: -The Lipid Hypothesis: From Resins to Proprotein Convertase Subtilisin/Kexin Type-9 Inhibitors-The Role of SGLT2i in the Prevention and Treatment of Heart Failure-Natural Products and Semi-Synthetic Compounds as Antithrombotics: A Review of the Last Ten Years (2009-2019)-Transient Receptor Potential Channels: Therapeutic Targets for Cardiometabolic Diseases?-Treatment of Raynaud's Phenomenon-Traditional Medicine Based Cardiovascular Therapeutics-Cardiovascular Disease: A Systems Biology Approach

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. This volume presents the following reviews: Electroluminescent polymers - a review on synthesis from organic compounds. Remarkable advances in the asymmetric synthesis of biologically active natural compounds from the advent of chiral auxiliaries. The chemistry of ynamides and their application in organic synthesis Carbon-heteroatom bond formation for medium ring heterocyclesTin(ii) salts: versatile and efficient lewis acid catalysts in reactions to add value to the glycerol and terpenic alcohols(E)-n-methyl-1-(methylthio)-2-nitroethenamine (nmsm) as a versatile ambiphilic synthon in organic synthesis

During my lifetime, I have been fortunate to have traveled to andlived in many places, staying in some for only two days, in others, muchlonger. This collection of haiku and senryu does not include all that Isaw and wrote. These poems are some of the images, impressions andmemories. Changes occur over time, and what I wrote about ten, twenty, thirty years ago and more, may not be true now.

VERSION SANS IMAGES (Version Deluxe avec images disponible)L'histoire d'une famille de 5 raconté en toute authenticité d'un rêve trop grand pour être contenu: Avides d'aventure depuis toujours, Annie et son mari Martin s'enfuient de leur Québec natal en 2016, accompagnés de leurs trois jeunes enfants alors âgés de 5, 6 et 7 ans. Armés de courage et de persévérance, ils prennent la mer sans aucune expérience préalable de navigation, outre quelques jours par-ci, par-là. Aspirés par la consommation compulsive et plongés dans un quotidien qui ne leur va plus, ils sont en quête du plus grand que soi, d'une expérience de bonheur, complète et inspirante, pour vivre dans la simplicité pure.Ils poursuivent un de leurs rêves le plus fou. Ils font le tour d'une partie de ce monde en voilier, certes, mais surtout le tour d'eux-mêmes. Ils reviennent sur terre transformés, angoissés, incertains sur les valeurs occidentales véhiculées mais reste convaincus que leur nouveau destin surpassera leurs plus grandes aspirations.Extrait Chapitre 14À 0200, je me lève pour mon quart de nuit. C'est le summum d'une navigation de nuit. L'air est chaud et confortable. Les étoiles scintillent par milliers, contrastant avec ce fond noir infini. La Voie lactée est franche et traverse le ciel en entier, touchant l'horizon de bâbord à tribord. Les étoiles filantes sont trop nombreuses pour les compter. Le vent est constant et il y a peu de vagues. Tout est calme et serein autour de moi. Le bateau avance bien, tout le monde dort paisiblement. Je savoure ce moment seule avec moi-même dans cette nuit réconfortante, avec la mer, avec cette immensité et avec ce monde plein de mystère sous mes pieds. Je souhaite que ce moment ne s'arrête jamais, précieux et impeccable. Puis trois heures plus tard, qui ne m'apparaissent qu'un moment, je m'installe sur la banquette extérieure pour dormir mon quart de nuit quand Martin me remplace.Extrait Chapitre 17Pas question de prendre un taxi à cette heure. Il n'y a pas d'ambulance ici. Nous essayons en vain de rejoindre les pompiers. Nous réussissons à rejoindre les policiers. Ils viendront escorter Nelson et Martin à l'hôpital. Mais les policiers sont tellement corrompus... Ils arrivent une vingtaine de minutes plus tard. Nelson et Martin partent ainsi, me laissant derrière, totalement dénuée de pouvoir. Je reste seule dans la rue désertique à les regarder s'éloigner en refoulant mes sanglots. Je me répète continuellement que je dois rester brave pour mes enfants. Je m'inquiète atrocement et les idées tournent trop vite dans ma tête. Je me crée des scénarios des plus atroces, comme un film d'horreur. Il est 0400 du matin et je n'ai pas encore fermé l'oeil de la nuit. J'ai peur pour mon garçon. Peur pour mon amour. Peur de cette ville meurtrière. Peur que cette ville ne les efface à jamais sans laisser de traces. Peur de cette nuit noire. Une peur viscérale de la part d'un coeur de maman.

Des bonnes résolutions, oui parfait, mais diable comment faire ! Est-ce que je vais tenir mes engagements ? Tous les jours ? Mois après mois, pour un résultat satisfaisant ? Et puis j'ai tellement de projets, prendre soin de ma santé, crée une entreprise, passer plus de temps avec mes proches: il ne faut rien que j'oublie, c'est important ! L'idéal serait que je dispose d'un support pour visualiser mes progressions. Un outil qui me rappelle tous les jours où j'en suis dans mon objectif ! Avec le carnet personnel des bonnes résolutions, vous allez pouvoir faire un suivi précis de vos engagements, des cases sont prévu pour que vous puissiez chaque jour cocher si oui ou non vous avez effectué les tâches nécessaires à la réalisation de vos objectifs. Chaque mois, un conseil vous est suggéré pour vous encourager ! Le plus dur est pour vous ! Ce carnet est un support pour vous permettre d'avoir une vue d'ensemble sur le respect de vos engagements. Néanmoins le plus important, c'est de passer à l'action, donnez-vous les moyens de réussir !

Depuis la révolte d'Aleria en 1975, la Corse a occupé la Une des médias, évoluant dans le fracas des bombes et les drames à répétition. L'auteur raconte, dans ce Tome 1, une page de l'histoire contemporaine de la Corse depuis ces années 70, une période rythmée par la clandestinité politique armée. Abordant les débats qui ont pesé sur le mouvement corse depuis les années 70, il revient sur un certain nombre de concepts et thèmes récurrents au sein de la mouvance nationaliste, sans occulter ses zones d'ombre, et sur les questions induites, à la base des multiples scissions, dissidences ou recompositions survenues. Du "Fronte Paesanu Corsu di Liberazione", (FPCL), apparu en 1973, au FLNC créé le 5 mai 1976, en passant par "Ghjustizia Paolina", cette clandestinité s'est enracinée depuis les années 70 dans la vie politique de l'île. Marginale à ses débuts, puis tentaculaire et omniprésente, elle s'est imposée comme la partenaire-clef dans les diverses "négociations" menées depuis par les gouvernements successifs dans l'île. Mythifiée ou vilipendée, elle est devenue au fil des années un élément majeur du paysage politique insulaire. Entre témoignage et essai politique, l'auteur retrace dans ce Tome 1, l'itinéraire de cette clandestinité depuis les années 70, du temps où le nationalisme corse, balbutiant puis en phase ascendante, était lié au FLNC alors uni, jusqu'au début des années 90, où le mouvement nationaliste allait se perdre dans des divisions suicidaires, désespérant nombre de militants....Derrière les faux-semblants et les clichés d'un néo-folklore, l'auteur entrouvre la porte de certaines coulisses où s'est écrite l'Histoire contemporaine corse, une histoire étroitement liée à cette clandestinité qui a profondément marqué les quatre dernières décennies de l'île.Pierre Poggioli, responsable nationaliste de la première heure, ancien responsable FLNC, ancien élu à l'Assemblée de Corse (1984-1998) est l'auteur de plusieurs ouvrages sur la situation politique contemporaine de l'île. Il est docteur en science politique comparée.

Based during the Industrial Revolution in a small, rural Pennsylvania town, "A Sign of the Times" is designed for Young Adult readers to teach them history and the importance of education in an ever-changing world.

★★ Fall in love with cozy small-town romance filled with delightful characters and brimming with holiday joy.★★ He's been all over the world. She's a home-town girl. Can a holiday wish bridge the gap?In Cora Carpenter's small California hometown, Christmas is tailor-made for couples. Unfortunately, Cora is a party of one, thanks to a con man who stole her heart, then bilked her out of thousands of dollars.What's on her Christmas wish list this year? Nothing whimsical. She'll take a new vacuum cleaner, thanks-and no dating for the foreseeable future. But when she meets a stranger with a broken-down car, his warm smile and perilously blue eyes almost make her want to tweak that list. If only she could get over the pain and humiliation of her past.A double whammy of betrayal and a broken heart sent anchorman Patrick Gervez thousands of miles west looking for a fresh start. But the pretty child care provider's unforgettable amber eyes and deft hand with a set of jumper cables does funny things to his heart-and makes him wonder if she's a forgotten dream come true.Except she's as skittish as a piece of tinsel in a windstorm. And the only way to help her forget her heartbreak, is to convince her to forgive. Especially herself.This heartwarming, sweet and wholesome contemporary holiday romance will rekindle your belief in love, Christmas, and Happily-Ever-After. Perfect for fans of Debbie Macomber, RaeAnne Thayne, and Susan Mallery. This story celebrates the joy, blessings, and true meaning of Christmas. Readers are saying: "Cora's story is sweet and touching," and "Whether you're short on time or not, this wholesome, inspirational holiday story is sure to lighten your heart and put a smile in your soul, so don't miss it." A Chocolate-Box Christmas Wish is the perfect gift to yourself. Scroll up and order today!

Birthday girl Ryder gets everything she doesn't want and nothing she really wants for her birthday. One failed wish after another, Ryder begs God to grant her just one wish. Will Ryder get the one thing she really wants for her birthday? Read this short fun story and you will see.

Detective Atticus Ware gave up Idaho to start again in the California mountains, close to his imprisoned brother. Although he's found good friends, the experienced Dominant wants more than the "do me" submissives flocking around him. He needs a woman to give her heart as well as her body.After Virginia Cunningham exhausts herself propping up a failing relationship, she accepts a social worker job far, far away in a California prison. Invited to observe BDSM classes on a wilderness camping trip, she's shocked-her fiancé had insisted BDSM was a fabrication to sell books. But when Atticus lures her into participating, she learns submission under the hands of a powerful Dom is beyond anything she'd imagined. Nonetheless, she can't permit a relationship-she'd just lose herself again.Finally, Atticus has found the woman he wants in his life. In his bed. In his cuffs. Only she keeps backing away. Well...if he has to help a little counselor get her head on straight, he's just the Dom for the job.

The best part of being a parent are those moments you get to engage and have fun with your children. Spurring great conversation and engagement are some of the most treasured moments that will last a lifetime. This book helps parents and their children to discover those moments.This father-and-daughter team holds double black belts in the "Art of the Special Day." They truly believe what the little plaque says on Breton's great-nanny's bathroom wall: "We don't remember days, we remember moments." This little sign's tattered patina relays a message that has seemingly been delivered through the ages, again and again, the reminder that our journey through life is made of brief memories, and those brief memories enrich our life and shape our legacy. Breton (age 9) and Tyler (age 42) have put together three of their favorite games that will get you started on maxing-out your adventure. Some random fun things to do...if you and your teammate are up for an adventure! Coffee Talk: Project Special Day offers a host of fun adventures that will enrich and deepen your most special relationship between a parent and child.Looking for a fun group of activities to do with your child on your next adventure CLICK BUY and take Coffee Talk Special Day with you.

'Take off your clothes, ' he commanded. She shivered and bent to unlace her boots. 'No, ' he said slowly, 'start with your blouse. I want to see what it is I've won...' The New Year sky is heavy with snow on the night Helen surrenders her body to a stranger. She loses her virtue on the roll of a dice and the wager sets tongues wagging. Though there are many illicit goings-on in the Fens in the 1920s, for the squire's sister-in-law to run off with a boatman is a scandal. But brave and beautiful Helen doesn't care. If she finds winter warmth and steamy romance in the strong arms of Jack Hartman then that, so she thinks, is a private affair...