Books published by Cold Spring Harbor Laboratory Press,U.S.

Twenty-four true, wide-ranging tales of crime, history, human behavior, illness, and ethics, told from the personal perspective of the author, an eminent physician-lawyer who uses the stories to illustrate the principles of human genetics and to discuss the broader issues.

Receptor tyrosine kinases are cell-surface receptors that respond to numerous hormones and growth factors, including insulin, insulin-like growth factors, epidermal growth factor, and nerve growth factor. They activate highly conserved intracellular signaling pathways that regulate cell proliferation, differentiation, and metabolism, playing essential roles in developing and adult animals. This book examines the nature of these receptors and their ligands, the molecular mechanisms that they regulate within cells, and the roles of the receptors in normal physiology and control of embryogenesis. It also discusses how dysfunction of these mechanisms can contribute to cancer and other diseases.

The majority of PhDs trained in biomedical sciences do not remain in academia. They are now presented with a broad variety of career options, including science journalism, publishing, science policy, patent law, and many more. This book examines the numerous different careers that scientists leaving the bench can pursue, from the perspectives of individuals who have successfully made the transition. In each case, the book sets out what the job involves and describes the qualifications and skills sets required.

Bacterial pathogens cause numerous human diseases. This collection from Cold Spring Harbor Perspectives in Medicine surveys the spectrum of bacterial pathogens from Salmonella and Shigella to Heliobacter pylori. It examines the basic biology of these parasites, their virulence mechanisms and the host's response to infection. The effectiveness of antibiotics and vaccine strategies are also covered, along with the novel antimicrobial therapies that are being developed.

During endocytosis, extracellular molecules and plasma membrane components are selectively internalized by cells. This fundamental process of "cellular ingestion" is required for diverse activities such as nutrient uptake, cell adhesion and migration, signal transduction, cytokinesis, neurotransmission, and antigen presentation. Pathogens (e.g., HIV) exploit endocytic pathways to gain entry into cells, and defects in the endocytic machinery can lead to diseases such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all of the major pathways of endocytosis and post-endocytic trafficking, and how they regulate cellular and organismal physiology. Contributors describe how cargo enters the cell via clathrin-mediated and clathrin-independent pathways, including caveolar endocytosis, micropinocytosis, cholesterol-sensitive endocytosis, phagocytosis, and the CLIC/GEEC pathway. They review the numerous machineries (e.g., Rab GTPases, tethering factors, and retromer) that transport cargo through endosomes and deliver it to lysosomes or recycle it back to the cell surface, and the signals and mechanisms governing these sorting decisions. Topics such as lysosomal dynamics, the biophysical challenges of bending membranes, and the evolution of endocytic systems are also covered. This volume also includes substantial discussion of the roles of endocytic trafficking in organismal development, physiology, and disease. It is thus an indispensable reference for cell biologists, but also neuroscientists, immunologists, developmental biologists, microbiologists, and others concerned with the physiological and therapeutic implications of this key cellular process.

Cell death plays a critical role in development, normal physiology and many diseases, including cancer. Research in this area is rapidly advancing and involves a variety of specific techniques. This manual provides a step-by-step guide to these techniques, along with background information informing researchers when they should be used.

In the 1920s, the groundwork was laid for a uniquely Russian approach to medical genetics and (the foundation of) the world's leading center for the study of human genetics and susceptibility to disease. The immense success of the movement, which is little known even to Russians, is brought to life in V.V. Babkov's The Dawn of Human Genetics, as is its dramatic and violent end, which resulted in the purge of many of the country's finest biologists and a major setback to the development of science internationally.

Parkinson's Disease is an incurable neurodegenerative disease characterized by a progressive loss of dopaminergic neurons that leads to slowness of movement, muscle rigidity, and tremors. Insoluble aggregates of proteins such as alpha-synuclein accumulate in the affected neurons, which also appear to be subject to oxidative stress. This collection from Cold Spring Harbor Perspectives in Medicine discusses recent work that has begun to uncover the molecular mechanisms that underlie the condition, including studies that implicate dysfunction of mitochondrial proteins such as parkin and pink1.

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing cells in the pancreas by the body's immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of