Books published by CRC Press

In recent years, the private rented sector has overtaken social housing to become the main housing provider with some of the worse housing conditions that are linked to preventable health inequalities. This book seeks to expand upon previous research in the area with a focus on selective licensing and enforcement, using a case study to illustrate changes in working practices that have been bought about through new powers being made available to local authorities to issue civil financial penalties upon criminal landlords.The book examines the impact of this legislation on regulatory enforcement in the London Borough of Newham's property licensing scheme, delivered in a multi-agency partnership across its private rented sector, and the outcomes of combining the use of licensing and traditional housing inspections with use of civil penalties in alternative to prosecution to address some of the worse effects of poor housing.The study also considers the limitations of employing informal actions to address such issues as well as identifying both the barriers to collaboration and the most effective strategies for service delivery where agencies - such as the police, border agency, council tax and local planning, irrespective of inter-agency competition - work together to achieve individual and shared objectives in evolving partnerships. The findings here will be of keen interest to environmental health professionals, academics, and indeed those operating in local authorities themselves.

This international anthology presents case studies of historical and contemporary transformations of large technical systems such as railways, telecommunications, electricity, and automobiles. The authors, working at the forefront of historical and social science research on the dynamics of large technical systems, analyze how and why these systems undergo change. Because of their important roles in contemporary society, large technical systems such as railways, airlines, road systems, telecommunications, and electric power network share drawing considerable academic and political interest. In this collaborative study on processes of change in large technical systems, the contributing authors present historical and current case studies of transformation within these systems. Working at the forefront of historical and social science research on the dynamics of large technical systems, the authors specifically analyze how and why the systems undergo change. In some cases, new technologies are solving old problems and presenting opportunities for system growth. In other areas, new regulatory approaches have brought competition and deregulation, often posing challenges to system builders. The authors also show how the breakup of national boundaries and new corporate strategies for global management of technology are transforming systems in ways that will have significant impacts on all consumers

This book covers the morphological characteristics, ethnopharmacological properties, isolated and identified structurally diverse secondary metabolites, biological and pharmacological activities of medicinal plants. Ethnopharmacology is the systematic study of folklore/traditional medicines, which continue to provide innovative drugs and lead molecules for the pharmaceutical industry. In fact, plant secondary metabolites, used as a single molecule or as a mixture, are medicines that can be effective and safe even when synthetic drugs fail. Therefore, the description of these secondary metabolites as well as methods for the targeted expression and/or purification is of high interest.In addition to surveying the morphological features, ethnopharmacological properties, biological and pharmacological activities, and studies of clinical trials, this book offers a comprehensive treatment of 56 plant species. It also presents the cell culture conditions and various methods used for increasing the production of medicinally important secondary metabolites in plant cell cultures.This volume: - Provides the morphological features, habitat, and distribution of each species of 56 genera selected from the different regions of the world. - Presents ethnopharmacological applications of various species of the 56 genera included in this book. Different species of 56 genera are used for ethnomedicinal uses by the people of various countries of the world.- Describes structures of various secondary metabolites identified in 56 plant species together with their biological and pharmacological activities.- Discusses strategies of secondary metabolites production, such as organ culture, pH, elicitation, hairy root cultures, light, and mutagenesis.- Provides a complete overview of each species of 56 genera and complete information up to 2022.Ethnopharmacological Properties, Biological Activity and Phytochemical Attributes of Medicinal Plants is an important book for undergraduate and postgraduate students, pharmacologists, phytochemists, Ayurvedic practitioners, medical doctors, and biotechnologists interested in the ethnopharmacological properties, phytochemistry, and biological and pharmacological activities of plants.

Greenfield's is the world's leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. The tenth edition features fully updated sections covering CNS tumours, neurodegeneration, skeletal muscle, epilepsy, paediatric and forensic neuropathology.Expert coverage from an international team of Editors and contributors ensures authoritative and up to date content. The two volume set includes a downloadable and easily used e-version. This is a tried and tested reference for scientists, clinicians, researchers, and students who wish to learn more about neurological disease.

Cancer is a deadly disease that puts not only physical and financial pressure on the patient but also even more psychological pressure. Physical deterioration in health and financial losses are easy to see but the psychological effects are not as visible; however, the psychological aspects are an important component in measuring any patient's Quality of Life (QoL, or balance between physical, psychological, social, and spiritual components).The present study is a small step in the direction of measuring QoL of cancer patients and the potential positive impact of changes in counselling. The association between QoL and other parameters, especially fear, leads to the recommendation to set up counselling centres at each hospital in its oncology department.

This book will serve as an introduction to microscopy and biomedical imaging methods, focussed on the study of the distributions and dynamics of molecules on the cell surface.

Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on clinical topics, including The use of digitalization and precision medicine in the IVF clinic, The environment and reproduction, The use of gonadotropin-releasing hormone agonists and the efficiency of IVF, Controlled ovarian stimulation for freeze-all cycles, Immunology in ART, Home monitoring of ART cycles, Luteal-phase support in ART, The POSEIDON stratification of 'low prognosis' patients in ART, Controlled ovarian stimulation for low responder patients, Adjuvants for poor responders, Innovative therapies in diminished ovarian reserve and primary ovarian insufficiency patients, and Fertility options for transgender and nonbinary individuals. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.

This book is an up-to-date reference on phosphorus nutrition in plants. Phosphorus has no substitute in food production, and the use of phosphate (Pi) fertilisers has increased crop yields to feed billions of people. This book covers phosphorus metabolism and phosphorus sensing molecular mechanisms and signalling in plants. It covers functions of phosphorus and crosstalk with other nutrients. It discusses how plants sense Pi deficiency and coordinate the responses via signalling pathways and networks for the regulation of Pi-deficiency responses.FEATURES Discusses the latest developments in phosphate management in plants Provides insights on emerging topics for sustainable approaches to managing phosphate shortage Throws light on the resilience of plants to phosphate deficiency Provides extensive updates that serve as primary points for further research Explains molecular and physiological mechanisms of phosphate transport This book compiles the latest research from experts in the field. It is useful for advanced graduates and researchers in plant sciences and agriculture.

Modeling with differential equations is an effective tool to provide methodical and quantitative solutions to real-world phenomena including investigating measurable features, consolidation and processing of data, and designing and developing complex engineering systems. This book describes differential equations correlation with qualitative and quantitative analysis, and mathematical modeling in the engineering and applied sciences. Given equations are explained from multidimensional characterizations with MATLAB(R) codes.Features: Addresses differential equation-based approaches to solve varied engineering problems Discusses derivation and solution of major equations of engineering and applied science Reviews qualitative and quantitative (numerical) analysis and mathematical modelling Includes mathematical models of the discussed problems Discusses MATLAB(R) codes Features: code and online materials related to the differential equations.This book is aimed at researchers graduate students in electrical and electronics engineering, control systems, electron devices society, applied physics, and engineering design.

The new age space value chain is a complex interconnected system with diverse actors, which involves cross-sector and cross-border collaborations. This book helps to enrich the knowledge of Artificial Intelligence (AI) across the value chain in the space-related domains. Advancements of AI and Machine Learning have impactfully supported the space sector transformation as it is shown in the book."This book embarks on a journey through the fascinating realm of AI in space, exploring its profound implications, emerging trends, and transformative potential."Prof. mult. Dr.med. Dr.rer.nat. Oliver UllrichDirector Innovation Cluster Space and Aviaton (UZH Space Hub), University of Zurich, SwitzerlandAimed at space engineers, risk analysts, policy makers, technical experts and non-specialists, this book demonstrates insights into the implementation of AI in the space sector, alongside its limitations and use-case examples. It covers diverse AI-related topics applicable to space technologies or space big data such as AI-based technologies for improving Earth Observation big data, AI for space robotics exploration, AI for astrophysics, AI for emerging in-orbit servicing market, and AI for space tourism safety improvement. Key Features: Provides an interdisciplinary approach, with chapter contributions from expert teams working in the governmental or private space sectors, with valuable contributions from computer scientists and legal experts; Presents insights into AI implementation and how to unlock AI technologies in the field; Up to date with the latest developments and cutting-edge applications Matteo Madi, Ph.D., is an entrepreneur, innovator, business developer and space-tech specialist with many years of experiences in the Swiss and International public and private sectors. He is the founder of Sirin Orbital Systems AG, a Swiss innovative company based in Zurich, focused on the development and commercialization of advanced enabling technologies for the needs of emerging space market and future sustainable space exploration. It also creates innovative solutions for the use of space technologies and satellite-based services for terrestrial applications. Olga Sokolova, Ph.D., is a risk analyst proficient in critical infrastructure risk assessment to natural and technical hazards. She has been engaged in development and analysis of structural risk-management tools towards sustainable future and has a record in raising social awareness of spaceborne risks and opportunities brought to the society by the "New Space" industry developments. Along with Dr. M. Madi, Dr. O. Sokolova is the Co-Editor of the book entitled, "Space Debris Peril: Pathways to Opportunities", published by CRC Press: Taylor and Francis in November 2020 (ISBN 9780367469450).

Echocardiography is the most powerful and cost-effective imaging technique for assessing patients suffering from unstable cardiovascular diseases. This didactically structured 3rd edition of "Emergency echocardiography" contains fully re-written chapters by well known, internationally recognized contributors. It includes new chapters on echo-guided patient management in the ICU, lung ultrasound and complications of percutaneous interventions with special attention to Focus Cardiac Ultrasound in emergency settings. Uses over 600 video loops of illustrative cases to interest a wide readership of all medical professionals involved in diagnostics and treatment of emergency cardiovascular patients.Key features: - Covers the role of cardiac ultrasound in most cardiovascular emergencies and emergency settings.- Offers clinically useful information to a wide range of medical professionals dealing with cardiovascular emergencies, including cardiologists, emergency physicians, anaesthesiologists, intensivists, and related fellows.- Features over 600 carefully chosen videos of illustrative cases with detailed explanations and highlights key decision management points.

Peter Meisen, Past President, Global Energy Network Institute, asked in 1997, "What if there was an existing, viable technology, that when developed to its highest potential could increase everyone's standard of living, cut fossil fuel demand and the resultant pollution?" After 23 years of sustained effort by the global scientific community, this is becoming a reality.The technology to extract heat from granite has been revolutionized in the last few years. The classical method of creating fracture networks by hydrofracturing is being replaced by a closed-loop method where fluids are not in contact with the hot granite. Supercritical CO2 is replacing water as a circulating fluid. Certainly, the future energy road is going to be led by highly radiogenic granites. While hydrothermal sources are site-specific and have their limitations, EGS can be initiated anywhere on earth. EGS is removing all such obstacles and, in the future, will provide uninterrupted electricity for all. Energy-deficient countries can have surplus electricity; water-stressed countries can have a perennial freshwater supply; and countries can become food-secure and rise above poverty levels. Countries need not depend on energy imports and can independently evolve into carbon neutral or low carbon societies.The contributions made by experts will help researchers and investors to close the energy demand and supply gap in the very near future by tapping the unlimited energy of the Earth. Opportunities available for investors in Turkey are well documented with field, geophysical, and geochemical data and information on the energy generating capacity of the granite intrusive spread over a cumulative area of 6,910 km2 in western Anatolia. With the signing of the Global Geothermal Alliance (GGA) by several countries during the December 2015 CoP 21 (Conference of Parties) summit in Paris, countries are obliged to reduce CO2 emissions by increasing the footprint of renewable energy in the primary source mix. Information provided in this book will lead the way to establishing a clean energy future for millions of people for sustainable development and help to mitigate crises arising due to food, water, and energy shortage issues. Academic and research institutes will benefit to a large extent from the expertise of the top contributors in this book. This information provided in this book will help to lay the foundation for super-hot EGS research in future.

This book explores the current difficulties and unsolved problems in the field of particle therapy and, after analysing them, discusses how (and if) innovative Monte Carlo approaches can be used to solve them.

This book gives a reliable review on structure selection of stochastic dynamic systems using information criteria AIC, BIC, o and stochastic complexity. After theoretical investigations many simulations are estimators, which illustrate both the effectiveness and the limitations of these methods. The reader can gain his or her own experience on the"working" of many methods (associated with different parameter estimators) using the demonstration disk which can be run on most IBM-compatible personal computers. The book will be helpful to anybody interested in applying automated methods of model-structure selection inn control engineering, in time series analysis or in signal processing.

This book explores the concept of greening industrialisation and issues and considerations surrounding it through the lens of Sub-Saharan Africa.The book critically examines the concept of greening industrialisation and describes the progress and data challenges of monitoring the Sustainable Development Goals confronting African countries. The chapters summarise the policy and programme literature focused on eight policy regimes essential for greening industrialisation and identify opportunities for greening industrial policies. The authors lay out a research agenda that would inform, enable, and support greening industrialisation in Sub-Saharan Africa and provide an overview of green industrial plans that include climate strategies, energy efficiency strategies, and green industry assessments. This book will be of great interest to students, scholars, policy-makers, and planners in the fields of Sub-Saharan African development and African environmentalism.

Some animals and plants injure or kill millions of people annually, others cause trillions of dollars in property damage and loss. Such harmful species are understandably hated. However, the vast majority of the planet's millions of species are disliked simply because of how they look and act. This bias is endangering numerous species that play important roles in maintaining both the natural ecosystems and the human economies of the world. In Defense of the World's Most Despised Species examines the psychological motivations that lead people to make judgments about the attractiveness of species, noting the overwhelming importance of visual cues. It describes in considerable detail the physical and behavioral traits of species that lead us to love or hate them. Full color illustrations throughout present beautiful, charming animals and plants, species that seem loathsome, behavior of people in relation to such divergent species and their characteristics, and numerous explanatory diagrams of relevant biological and psychological phenomena. The aim of this book is to give readers insights into how we humans arrive at biased judgments and to promote the welfare of valuable, albeit sometimes unlovable animals and plants that consequently suffer from discrimination. Many of the ugliest, most disgusting, and feared species, such as vultures, toads, hyenas, sharks, spiders, and even the vast majority of cockroaches, in reality are some of our most valuable friends.Features Theme of the book - human preferences for and against species - is novel, scarcely examined to date. Multidisciplinary analysis, especially psychology, biological conservation science, and ecology, as well as philosophy, agriculture, urban planning, human health, and law. Text is accessible, user-friendly, concise, and well-organized, making numerous complex topics comprehensible, readable not only by specialists, but also by students and the educated layperson. Includes over 2,000 high-quality, entertaining, and informative color figures.

This book presents a comprehensive treatise on community ophthalmology principles and practices for countries with developing and emerging economies. It is replete with chapters on basic epidemiology, health economics, basic statistics and lays the foundation of the global eye health-care programs with skills for community-based epidemiological projects in eye care. With extensive experience in conducting various epidemiological surveys funded by the Ministry of Health, WHO, Indian Council of Medical Research, etc., the editors provide practical knowledge to ophthalmologists, public health specialists, physician-scientists, researchers, eye care program managers, optometrists, and academicians involved in community ophthalmology operational studies.Key Features: - Presents a single platform for knowing everything about community ophthalmology from statistics and epidemiology to financing in an easy and succinct manner.- Serves as a robust resource and an advanced teaching tool for medical professionals.- Includes well-illustrated, succinct chapters for better understanding of various aspects of public health in eye care.- Provides tips and tricks for dealing with both expected and unexpected situations while conducting epidemiological research and data collection in the field.

Featuring contributions by an international team of the world's experts in urology and gynecology, this fifth edition reinforces its status as the classic comprehensive resource on female urology and urogynecology and an essential clinical reference in the field. There are new chapters throughout and new commentaries on important documents in the appendixes; each volume is now available separately. *Offers a comprehensive guide to surgical aspects *Covers important and common topics such as pelvic organ prolapse and robotic surgery and newer topics such as transgender surgery *Presents a practical and manageable level of detail

This textbook provides an introduction to the fundamental and applied aspects of biophysics foradvanced undergraduate and graduate students of physics, chemistry, and biology.The application of physics principles and techniques in exploring biological systems has longbeen a tradition in scientific research. Biological systems hold naturally inbuilt physical principlesand processes which are popularly explored. Systematic discoveries help us understand the structuresand functions of individual biomolecules, biomolecular systems, cells, organelles, tissues, and eventhe physiological systems of animals and plants. Utilizing a physics- based scientific understandingof biological systems to explore disease is at the forefront of applied scientific research.This textbook covers key breakthroughs in biophysics whilst looking ahead to future horizonsand directions of research. It contains models based on both classical and quantum mechanicaltreatments of biological systems. It explores diseases related to physical alterations in biomolecularstructures and organizations alongside drug discovery strategies. It also discusses the cutting- edgeapplications of nanotechnologies in manipulating nanoprocesses in biological systems.Key Features: - Presents an accessible introduction to how physics principles and techniques can be used tounderstand biological and biochemical systems.- Addresses natural processes, mutations, and their purposeful manipulation.- Lays the groundwork for vitally important natural scientific, technological, and medicaladvances.Mohammad Ashrafuzzaman, a biophysicist and condensed matter scientist, is passionate aboutinvestigating biological and biochemical processes utilizing physics principles and techniques. Heis a professor of biophysics at King Saud University's Biochemistry Department in the College ofScience, Riyadh, Saudi Arabia; the co- founder of MDT Canada Inc., and the founder of Child LifeDevelopment Institute, Edmonton, Canada. He has authored Biophysics and Nanotechnology ofIon Channels, Nanoscale Biophysics of the Cell, and Membrane Biophysics. He has also publishedabout 50 peer- reviewed articles and several patents, edited two books, and has been servingon the editorial boards of Elsevier and Bentham Science journals. Dr. Ashrafuzzaman has heldresearch and academic ranks at Bangladesh University of Engineering & Technology, Universityof Neuchatel (Switzerland), Helsinki University of Technology (Finland), Weill Medical College ofCornell University (USA), and University of Alberta (Canada). During 2013- 2018 he also served asa Visiting Professor at the Departments of Oncology, and Medical Microbiology and Immunology, of the University of Alberta. Dr. Ashrafuzzaman earned his highest academic degree, Doctor ofScience (D.Sc.) in condensed matter physics from the University of Neuchatel, Switzerland in 2004.

The demands of producing high-quality, pathogen-free food rely increasingly on natural sources of antimicrobials to inhibit food spoilage organisms, foodborne pathogens, and toxins. The recent developments and innovations of new antimicrobials from natural sources for a wide range of applications require that knowledge of traditional sources for food antimicrobials is combined with the latest technologies in identification, characterization, and applications. This book explores novel, natural sources of antimicrobials as well as the latest developments in using well-known antimicrobials in food, covering antimicrobials derived from microbial sources, animal-derived products, plants, and value-added products. This book includes the development and use of natural antimicrobials for processed and fresh food products. New and emerging technologies concerning antimicrobials are also discussed.This bookconsiders recent developments and innovations in food technology in combating infectious diseases and explores advances in antimicrobial constituents and their applications in the fight against microbes. In addition, it also provides a variety of photographs, diagrams, and tables to help illustrate the material. The novel strategies to combat antimicrobial resistance are also described, emphasizing collaborative measures of control. Advanced topics in the volume include food processing, food security, preservation, nutritional analysis, quality control, and maintenance as well as good manufacturing practices in the food industries.Students, research scientists, academicians, and policy makers can benefit from Antimicrobials in Food Science and Technology as a resource that addresses microbial biotechnology, food microbiology, fermentation technology, ethnopharmacology, toxicology, microbial/medicinal plant products, and all disciplines related to antimicrobial research.Features of the book: Covers all food antimicrobials, natural and synthetic, with up-to-date research on each type Recent references on every conceivable food antimicrobial Describes recent laws and regulatory guidelines in the selection of appropriate additives for specific food products Includes innovations in natural antimicrobial value-added products Offers current and future applications of emergent antimicrobial technologies and the use of multifactorial food preservation with antimicrobials Details methods to improve antimicrobial properties to have a longer service life in combating infection

Written by a variety of experts in the field, this book explores the critical issues and current topics in nonclinical drug development. It covers individual topics and strategies in drug development from compound characterization to drug registration.

Building a clinically integrated workplace with a high level of clinical competence requires careful considerations to Hospital Planning. Green Field or Brown field Hospital Project, Clinicians and C-Suite Executives need to acquire capabilities to address the planning needs of any organization. This book aims to provide both theoretical and practical inputs for Planning and Designing of Health Care Facilities in developing countries. It clearly indicates the steps to be followed, facts to be weighed and components to be considered to arrive to a correct planning solution. With health reform looming and the revenue base shifting rapidly we need to integrate patient safety concerns in the Design Process. Key Features1. Liberal use of tables and figures to support conclusions, illustrate concepts and display quantitative information, making it easier for readers to understand and refer large quantities of data.2. Integrates the international norms for planning and designing of Healthcare Facilities into the developing country setting. 3. Handbook and ready reckoner for C Suite Executives, Hospital Engineers, Project Consultants, and students of Hospital Administration.

Including over 500 multiple choice questions covering a wide range of vascular disorders to test the skills of all vascular specialists. Suitable for postgraduate trainee vascular medicine internists, interventional radiologists, vascular surgeons, and endovascular therapists as they prepare for exams or ensure that they remain up to date. Divided into 21 subject specific sections and meticulously written and researched, the questions and their accompanying rationales are enhanced by explanatory illustrations and supported by key references. Students and experienced clinicians will be prepared for both testing and teaching in all aspects of clinical practice. Advances in the treatment of vascular disease have played a significant role in rising life expectancy over the past 70 years, resulting in lower morbidity, mortality, and quicker recoveries. However, there remains an urgent challenge in controlling risk factors such as obesity, sedentary lifestyles, and tobacco abuse. As explosive growth in endovascular technology continues, it is more important than ever for vascular specialists to remain proficient and stay up to date.

Forensic DNA Transfer provides a guide to the recognition and current understanding of DNA transfer in forensic criminal investigations. Increased improvements in technology mean that it is now routinely possible to obtain DNA profiles from non-visible deposits. How or when the DNA in question was deposited may be an issue in the context of the case, especially if the donor of the DNA is not in dispute. A DNA profile alone cannot reveal when or how that DNA was deposited at a crime scene, nor can it reveal the body matter from which it originated. Issues of transfer associated with activities may be debated--which the traditional discrimination purpose of DNA profiling cannot address.DNA may be everywhere and anywhere--in homes, workplaces, transport, and on personal items including clothing. DNA from a person may be on an object they have never contacted or in a room they have never entered. Concepts discussed in the book include non-self DNA on hands through day-to-day activities, the prevalence of background DNA in the environment and perhaps on the exhibit, the persistence of any DNA transferred, and that a DNA result will depend on these variables as well as recovery techniques. Since DNA may be transferred to an exhibit: (a) during the commission of a crime, (b) before the crime, and/or (c) after the crime through handling, examination, and testing, this text covers various transfer pathways and sources of DNA. Inadvertent issues of transfer of DNA resulting in wrongful convictions and the misleading of investigations are discussed, with an emphasis on contamination mitigation.Forensic DNA Transfer examines the additional complexity resulting from non-visible deposits of DNA that impact on sampling and testing regimes. The changing understanding of the composition of purported "touch DNA" deposits from the skin, including extracellular DNA transported via body secretions is described. Further, the newer focus on interpreting DNA evidence--using activity level propositions and the rationale and associated issues--is also discussed.

Established as the definitive reference for the IVF clinic, the sixth edition has been extensively revised, with the addition of several important new contributions on laboratory topics, including KPIs for the IVF laboratory, Quality control in the cloud, Artificial Intelligence, AI in gamete and embryo selection, Demystifying vitrification, Microfluidics, Gene editing, Disaster management, and Early human embryo development revealed by static imaging. As previously, methods, protocols, and techniques of choice are presented by IVF pioneers and eminent international experts.

After many years of teaching graduate courses in applied mathematics, Youssef N. Raffoul saw a need among his students for a book reviewing topics from undergraduate courses to help them recall what they had learned, while his students urged him to publish a brief and approachable book on the topic. Thus, the author used his lecture notes from his graduate course in applied mathematical methods, which comprises three chapters on linear algebra, calculus of variations, and integral equations, to serve as the foundation for this work. These notes have undergone continuous revision. Applied Mathematics for Scientists and Engineers is designed to be used as a graduate textbook for one semester. The five chapters in the book can be used by the instructor to create a one-semester, three-chapter course. The only prerequisites for this self-contained book are a basic understanding of calculus and differential equations. In order to make the book accessible to a broad audience, the author endeavored to strike a balance between rigor and presentation of the most challenging content in a simple format by adopting friendlier, more approachable notations and using numerous examples to clarify complex themes. The hope is both instructors and students will find, in this single volume, a refresher on topics necessary to further their courses and study.

Medical Generalism, Now! is a unique and timely consideration of generalist medical practice. With a focus on the knowledge work of clinical practice and by taking a whole healthcare system view, the book responds to a recognized need to strengthen generalist practice within modern healthcare delivery in both primary and secondary care settings. Through a series of creative provocations directed to consulting clinicians and their trainers/educators, service leaders and managers, and policy makers, readers are encouraged to challenge the orthodox view that generalism is an outdated 'Jack of all trades' sub-set of clinical medicine delivering the 'simpler' aspects of medicine, with more complex issues requiring onward specialist referral. Case studies are used throughout to illustrate the challenges to be faced, accompanied by a description of the principles of generalist knowledge work needed to tackle the scenarios described and discussing the implications for practice and service re-design. Essential reading for clinicians, managers and policy makers across all healthcare settings, the book concludes with a call to action, synthesizing the learning from each chapter to define and describe delivery of the key changes needed.

Mycotoxins are secondary metabolites produced by fungi in a wide range of foods (cereals, peanut, tree nuts, dried fruits, coffee, cocoa, grapes, spices...) both in the field and after harvest, particularly during storage. They can also be found in processed foods of plant origin, or by transfer, in food products of animal (milk, eggs, meat and offal). Mycotoxins are of major concern since they can cause acute or chronic intoxications in both humans and animals which are sometimes fatal. Many countries, particularly in Europe, have set maximum acceptable levels for mycotoxins in food and feed.The book reviews the latest literature and innovations on important aspects of mycotoxins, e.g. mycotoxin producing fungi and the related ecosystems, mycotoxin occurrence, toxicity, analysis and management. Quantitative estimations of impacts of climate change on mycotoxin occurrence have been made recently, using predictive modelling. There is also a growing interest in the occurrence and toxicity of multiple mycotoxins in food and feed, including emerging or modified forms of mycotoxins. Innovative tools were also developed to detect and quantify toxinogenic fungi and their toxins. In order to reduce the use of chemicals that are harmful to the environment and health of consumers, alternative methods of prevention and decontamination of mycotoxins were tested in pre- and post-harvest, using microorganisms, natural substances or radiation treatments.

Policymakers, farmers, managers of agriculture and others look to agricultural economists for accurate estimates of the costs and returns of individual agricultural commodities. But there is great diversity and disagreement among practitioners about the best method for such analysis. The contributors to this volume explore how different uses of estimates determine different methods of estimation, as well as evaluating what the preferred methods are for similar uses.

Vertebrate Skeletal Histology and Paleohistology summarizes decades of research into the biology and biological meaning of hard tissues, in both living and extinct vertebrates. In addition to outlining anatomical diversity, it provides fundamental phylogenetic and evolutionary contexts for interpretation. An international team of leading authorities review the impact of ontogeny, mechanics, and environment in relation to bone and dental tissues. Synthesizing current advances in the biological problems of growth, metabolism, evolution, ecology, and behavior, this comprehensive and authoritative volume is built upon a foundation of concepts and technology generated over the past fifty years.