Books published by Elsevier Science Publishing Co Inc

Cancer, a multifaceted disease, remains the leading cause of death worldwide. Ongoing research and technological advancements are continually improving the human understanding of newer treatment options. This book series aims to provide wide-ranging insights into the current landscape of cancer research, highlighting the recent advancements, current challenges, and future directions. Cancer varies widely in its formation, microenvironment, location in the body, associated risk factors, detection methodology, and treatment approaches. Early detection and prevention through lifestyle changes, regular screenings, and the awareness of symptoms are crucial for improving outcomes and survival rates. In this book series, the main focus is on trending topics, like new drug delivery, diagnostics, biomarkers, and preclinical and clinical developments in cancer research. Nanotechnology has emerged as a transformative approach in medicine, particularly in the areas of targeted drug delivery systems, imaging, and diagnostics to enhance the therapeutic efficacy and minimize adverse effects in cancer therapy. Advances in pharma, medical device, and diagnostic research, including the development of Trojan-horse therapies and precision treatments/assay kits, continue to enhance the effectiveness of cancer care over the past few decades. A total of five books are covered in this series: Drug Delivery Landscape in Cancer Research (Vol. 1)Biomarker Landscape in Cancer Research (Vol. 2)Diagnostic Landscape in Cancer Research (Vol. 3)Preclinical Landscape in Cancer Research (Vol. 4)Clinical Landscape in Cancer Research (Vol. 5) By integrating basic, applied, and innovative science concepts, this book series fosters a deeper understanding of the disease and paves the way for the development of more effective strategies. This book series serves as a valuable resource for students, researchers, regulators, and clinicians interested in understanding the complexities of cancer and the innovative approaches researched to combat this deadly disease. Nonetheless, continuous interdisciplinary, cross-country collaborations and cross-science innovation strategies are essential to further reduce the global cancer burden.

Biomedical and Clinical Cryogenics: Theory, Current Technology Advances, and Future Perspectives presents the complexity of cryogenic engineering applications in both medical and clinical settings. The book demonstrates both a comprehensive and up-to-date understanding of ongoing, new applications and their cutting-edge breakthroughs within the biomedical engineering sector. It contributes to the rapidly emerging and expanding field of cryogenics by emphasizing the complexity of associated mechanisms and interactions. In six chapters, this book collects, investigates, and critically discusses state-of-the-art cryogenic practices, along with the challenges and perspectives of the most common applications.By using cryogenics sciences, new milestones in medicine and human-life expectancy can be significantly increased. Since this is highly interdisciplinary content, this book is a valuable resource for biomedical engineers, health professionals, scientists, researchers, students, and all those who wish to broaden their knowledge in the allied field.

Nanotechnology of Veterinary Medicine and Livestock Production compiles the most impactful emerging research on the use of nanotechnology in animal sciences. This novel data, methods, and technologies will improve animal health, welfare, production, and nutrition, and will have implications for the future of human health, disease control, and food safety. Authored by a renowned animal toxicologist, this book introduces the history of nanotechnology in animal science before delving into its interdisciplinary applications. Central chapters explore nanomaterials in animal disease treatment, nanovaccine development, nanotechnology in animal nutrition and production, and applications for antibiotic-based therapies.Concluding chapters summarize the risks of these novel technologies, their challenges, and opportunities in various animal science sectors. This is an essential resource for researchers, clinicians, and animal scientists seeking information on cutting edge nano- and biotechnological advancements.

Human- Centric Integration of Next Generation Data Science and Blockchain Technology: Advancing Society 5.0 Paradigms focuses on the current technological landscape, addressing the evolving integration of data science and blockchain within the context of Society 5.0. This comprehensive resource explains the convergences between data science, blockchain, and the human-centric vision of Society 5.0, while also filling the gap in understanding and navigating this transformative intersection with recent shifts towards more decentralized and data-driven paradigms.The book introduces the concept of Society 5.0, examining the historical context, and outlines the evolving technological landscape shaping our interconnected future. It discusses the fundamental principles of data science, from data collection and preprocessing to exploratory data analysis and explains the transformative impact of data science and blockchain across industries such as healthcare, finance, education, and transportation. This book is essential to understanding and shaping the future of technology and society from decentralized solutions to predictive analytics/ emerging technologies.

Healthcare Frontiers in the Metaverse: Innovations and Impacts provides a deeper comprehension of the metaverse's revolutionary effects on patient care, medical education, and operational procedures in the healthcare sector. The book Includes both the fundamentals of patient experience, provider practices, and the overall framework of the healthcare business as the democratisation of medical education through virtual simulations and the individualised care enabled by AI-driven diagnostics. In 14 chapters "Healthcare Frontiers in the Metaverse: Innovations and Impacts" leads the reader to an introduction to, definition, elements, treatment and diagnostic in healthcare in metaverse, the next evolution in social connection and the successor to the mobile internet. It describes the role of robots and give a view on the future scope and challenges. " Exploration of Healthcare in Metaverse: Innovations and Impacts" serves as a road map for technologists and policymakers influencing the direction of healthcare as well as a help book for medical practitioners integrating metaverse technologies into their practice.

Control of Underactuated Mechanical Systems: Stabilization and Limit Cycle Generation clearly explains stabilization and limit cycle generation in underactuated mechanical systems (UMS), addressing control design challenges and demonstrating concepts through real-time experiments. The book begins with advancements in UMS, introducing key concepts such as stabilization and limit cycle generation, supported by literature examples. It then focuses on the inertia wheel inverted pendulum, presenting a detailed discussion. The second part tackles stabilization, offering various control solutions validated through numerical simulations and real-time experiments. The final part addresses stable limit cycle generation, detailing three proposed control solutions and their validation through different case studies. This book is a valuable resource for PhD and Master students, engineers, researchers, and educators. It provides guidance in robotics and automatic control, utilizing a simplified methodology for controlling underactuated mechanical systems.

An Overview of FDA Regulated Products: From Drugs and Cosmetics to Food and Tobacco, Second Edition is fully updated to reflect recent advances in science and technology and new laws and regulations. Breakthroughs in cellular and gene therapy, immunotherapy, precision medicine, and digital health are changing the face of healthcare and regulation. The updates brought about by the 21st Century Cures Act and subsequent PDUFA Reauthorizations, as well as signing into law the "Modernization of Cosmetic Regulation Act of 2022," which will transform FDA’s oversight of cosmetics, are fully reflected in all chapters of the book. This book provides graduate students and industry professionals with comprehensive information on approval processes with the FDA and other country regulation organizations. Regulatory science professionals working with not only drugs, but biologics, medical devices, food and additives, cosmetics, veterinary products, and tobacco will benefit from this comprehensive overview of the regulatory environment.

Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology and pathophysiological roles of cholecystokinin (CCK) peptides. It begins with a historical overview before providing in-depth chapters into the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, and the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function. Methods used for CCK research are also discussed. A number of chapters then cover the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.Cholecystokinin: From Gallbladder to Cognition and Beyond is a volume in the Molecular Mediators in Health and Disease book series, and acts as a fundamental reference on all biological and clinical aspects of CCK. This book is ideal for researchers interested in learning more about the role of CCK and its impact across health and disease.

Nano-bioinoculants: Smart Tools for Modern Agriculture discusses the interactions between nanoparticles and soil-plants-microbiome systems in a single-volume book designed to guide improvements in sustainable agriculture i.e. plant production and soil health. Past practices for the application of pesticides and chemical fertilizers have reduced the beneficial microbial diversity and soil fertility essential for optimal crop yield and overall plant health. As a result, developing innovative approaches to plant/soil health maintenance, bioremediation process, and stress management is advancing. Plant protection methods are increasingly being tailored to improve sustainable precision results, reduce environmental impact, and to target specific plant health challenges. Nano-bioinoculants: Smart Tools for Modern Agriculture explains nanoparticles and beneficial microbes and their impact on soil microbiomes, soil fertility restoration, remediation of contaminated soil, and plant health. It also highlights nanoparticles and bioinoculants in stress management, plant growth, and productivity, as well as covering the potentially toxic effect of nanoparticles on humans and the environment. This volume in the Nanomaterial-Plant Interactions series explores the potential of nano-biotechnology for better agronomic performance and sustainability.

The study of one-shot devices such as automobile airbags, fire extinguishers, or antigen tests, is rapidly becoming an important problem in the area of reliability engineering. These devices, which are destroyed or must be rebuilt after use, are a particular case of extreme censoring, which makes the problem of estimating their reliability and lifetime challenging. However, classical statistical and inferential methods do not consider the issue of robustness. Statistical Modeling and Robust Interference for One-shot Devices offers a comprehensive investigation of robust techniques of one-shot devices under accelerated-life tests. With numerous examples and case studies in which the proposed methods are applied, this book includes detailed R codes in each chapter to help readers implement their own codes and use them in the proposed examples and in their own research on one-shot device-testing data. Researchers, mathematicians, engineers, and students working on accelerated-life testing data analysis and robust methodologies will find this to be a welcome resource.

Mechanical Separation Processes in the Food Industry, a volume in the Unit Operations and Processing Equipment in the Food Industry series, explains the processing operations and equipment necessary for mechanical separation unit operations, including filtration, centrifugation, sieving, metal detection, sedimentation, etc. These processes and unit operations are very important in the manufacture of products such as cream, fruit juices, beverages, refining of edible oils and sugar. The book's chapters emphasize basic texts relating to experimental, theoretical, computational, and/or applications of food engineering principles and the relevant processing equipment for mechanical separation unit operations.Written by experts in the field of food engineering, and in a simple and dynamic way, this book targets industrial engineers working in the field of food processing and within food factories to make them more familiar with the particular food processing operations and equipment.

Handbook of Milk Production, Quality and Nutrition emphasizes new applications to promote healthy milk production, processing, and product development in the milk industry, highlighting the role clean milk has in the prevention of health and disease. Sections cover the general aspects of milk production and its environmental impact on animal health, explain milk’s global nutritional appeal and its role as a source of both macro and micronutrients for human health, address issues of lactose intolerance and how this ailment is perceived globally, and discuss milk’s relevance on bone, ocular, and gut health.Finally, the book brings awareness to milk’s microbial pathogens, toxins, and heavy metals, and health concerns, while also updating on regulatory health and nutrition claims and recent legislative developments.

Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies unveils a groundbreaking exploration of nanotechnology’s potential in revolutionizing drug delivery for colon-related ailments. Today, an array of colonic diseases, including colorectal cancer, colonic polyps, ulcerative colitis, and inflammatory bowel syndrome, pose significant medical challenges. Conventional methods to deliver drugs to this system prove difficult, with limited efficacy and notable side effects. This book delves into the intricate complexities of colonic diseases, their pathophysiology, and epidemiology to support pharmaceutical scientists in designing better drug delivery systems. Providing a comprehensive overview of the area, the chapters elucidate diverse targeting strategies, from time-dependent to microbiota-based drug delivery systems, and explore receptor-based and magnetically assisted delivery mechanisms. Case studies dissected the working mechanisms behind polymeric nanoparticles, polymersomes, polymeric micelles, solid lipid nanoparticles, and other nanocarrier systems tailored for colon targeting. Additionally, this book explores cuttingedge topics such as gold nanoparticles, supra-magnetic iron oxide nanoparticles, and protein-peptide-based nanoparticles, highlighting their mechanisms, applications, and potential toxicities. Merging an overview of colonic pathophysiology with in-depth reviews of each nanomaterial used for drug delivery and practical case studies, Nanocarriers Based Colon Targeting: Design, Development, Mechanism and Case Studies is a complete reference for pharmaceutical scientists involved in elevating drug delivery precision and therapeutic efficacy in this organ system. Toxicologists, material scientists, research physicians, and regulators can also benefit from the case studies developed by expert authors.

Generalized Quantum Calculus with Applications is devoted to the qualitative theory of general quantum calculus and its applications to general quantum differential equations and inequalities. The book is aimed at upper-level undergraduate students and beginning graduate students in a range of interdisciplinary courses including physical sciences and engineering, from quantum mechanics to differential equations, with pedagogically organized chapters that each concludes with a section of practical problems. Generalized quantum calculus includes a generalization of the q-quantum calculus and the time scale calculus. There are many open problems and difficulties in q-quantum calculus and time-scale calculus, and this book explores how to use the generalized quantum operators to solve difficulties arising in q-quantum calculus and time-scale calculus, including but not limited to generalized quantum integration, generalized quantum chain rules, and generalized quantum Taylor formula. Since generalized quantum calculus includes the q-quantum and time-scale calculus, this book can be utilized by a wide audience of researchers and students. This text is one of few foundational books on generalized quantum calculus and can be used for future discoveries in the area of integral transforms, variational calculus, integral equations, and inequalities in the language of generalized quantum calculus. This book also offers detailed proofs, exercises, and examples to aid instructors, researchers, and users in their studies.

Microbial Genomics: Host Adaptation, Virulence, and Evolution covers different aspects of microbial genomics, metagenomics, and functional studies of microbes that have provided a significant understanding of microbial-host interactions, virulence function, host adaptation mechanisms, including microbial evolution. Microbial Genomics: Host Adaptation, virulence, and Evolution is a comprehensive source on the latest updates and applications of microbial genomics information to understand the plant, microbe interaction, host adaptation, virulence nature of the infectious pathogen, microbial evolution, host-pathogen interactions contribute to shaping the genetic diversity of both organisms. Sections include an introduction to Microbial Genomics, followed by sections on Plant Microbiome, Genome Editing Prospecting and Approaches, Microbial virulanse and disease incidence. The final section of the book covers Microbial Genomics and evolutionary concepts. "Microbial Genomics: Host Adaptation, virulence, and Evolution" is a valuable resource for faculty members, researchers, and undergraduate and postgraduate students at universities, medical research labs, industries, and government agencies that are interested in the microbial science specific to the microbial genome, virulence function of pathogenic microbes, host adaptation, evolution of microbes, and all other disciplines related to molecular microbiology.