Books published by Elsevier Science Publishing Co Inc

The Immunological Synapse - Part B, Volume 178 in the Methods in Cell Biology series provides state-of-the-art methods for the study of the immunological synapse. This first volume covers various aspects on T cell and natural killer (NK) cell synapses, including imaging polarized granule release using TIRF microscopy, analysis of actin reorganization and centrosome polarization, redirected degranulation, live cell-imaging to quantify cytotoxic and chemotactic dynamics, quantification of interactions between APCs and T cells, assessment of membrane lipid state at the immunological synapse, proteomic analysis and imaging of NK-tumor cell interaction, evaluating natural killer cell effector functions against breast cancer cells derived from human tumor tissue, evaluation of chimeric antigen receptor (CAR)-modified cell immunological synapse quality using the glass-supported planar lipid bilayer, and monitoring potency of therapeutic CAR T cells. It also includes one chapter on quantification of lymphocytic choriomeningitis virus specific T cells and LCMV viral titers, and one chapter on the murine antibody-dependent cellular phagocytosis assay.

Senescence and Mitochondria Targeted Senotherapeutics, Volume 136 offers updates on this unique topics, with chapters covering Cellular Senescence in Aging: Molecular Basis, Implications and Therapeutic Interventions, Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives, Mitochondria in cell senescence: Friend or Foe?, The role of mitochondria and mitophagy in cell senescence, Small molecules targeting mitochondrial dysfunction for potential senotheraputics, Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, Mitochondrial targeting peptides and probes, Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases, and much more. Other sections cover Targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, Melatonin as mitochondria-targeted drugs, Coenzyme Q-related compounds to maintain healthy mitochondria during aging, Changing ROS, NAD and AMP: a path to longevity via mitochondrial therapeutics, and more.

Advances in Botanical Research Volume 108: Ozone Pollution and Plant Health: Understanding the Impacts and Solutions for Sustainable Agriculture provides a comprehensive overview of the harmful effects of tropospheric ozone (O3) pollution on crop productivity, with a focus on how it is measured and modeled under climate change scenarios. The book discusses the sources of O3 pollution, including anthropogenic precursor gases, and how O3 exposure can impair photosynthesis, reduce gas exchange, induce early leaf senescence, and hamper growth in natural vegetation and crops. The book highlights how O3 interacts with plant physiology and metabolism, including through the activation of signal transduction pathways, changes in phytohormone signaling, and modulation of reactive oxygen species (ROS) generation and signaling. The book also explores the experimental and modeling methods used to assess the effects of O3 on crops, with a focus on studies conducted in Asia. The book emphasizes the importance of understanding the implications of ozone pollution for ensuring food security and protecting human and environmental health and suggests strategies such as using ozone-resistant cultivars of plants and crops. Additionally, the book discusses the broader context of air pollution and its impact on crop productivity, including the effects of other air pollutants on plants and crops and the need for mitigation strategies and policies to address agricultural losses. This book is essential reading for early-career researchers, sustainable agriculture practitioners, and policymakers interested in understanding the complex interactions between ozone pollution and plant productivity and finding solutions to mitigate the detrimental effects of ozone pollution on crops in a changing climate.

Up and Running with AutoCADª 2024 presents a combination of step-by-step instructions, examples and insightful explanations. The book emphasizes core concepts and practical application of AutoCAD in engineering, architecture and design. Written with the user in mind, this book is equally useful in instructor-led classroom training, self-study or as a professional reference.

Partial Differential Equations and Applications: A Bridge for Students and Researchers in Applied Sciences offers a unique approach to this key subject by connecting mathematical principles to the latest research advances in select topics. Beginning with very elementary PDEs, such as classical heat equations, wave equations and Laplace equations, the book focuses on concrete examples. It gives students basic skills and techniques to find explicit solutions for partial differential equations. As it progresses, the book covers more advanced topics such as the maximum principle and applications, Green's representation, Schauder's theory, finite-time blowup, and shock waves. By exploring these topics, students gain the necessary tools to deal with research topics in their own fields, whether proceeding in math or engineering areas.

Competency Based Training for Clinical Supervisors builds upon the current competencies schema to design a framework for training programs. The book's authors begin with a practical program curriculum, addressing the challenges of treatment and workplace satisfaction. The next sections are divided based on transversal competencies, including intellectual order, methodological order, personal and social order, and communication order. The last section of the book is dedicated to ethics in both training programs and models for psychotherapy and clinical supervision.

AI in Clinical Practice: A Guide to Artificial Intelligence and Digital Medicine explains how artificial intelligence is applied to medicine, illustrating not only its enormous potential but also ancillary issues and the limits and risks inherent in its use on a large scale. The book focuses on the intersection between medicine and AI and its implications on the impact of human health care delivery. Topics discussed  include wearable devices, health data, Internet of Things, virtual reality, robotic assistance system, and digital intelligence in the health sector. Additionally, sections discuss diagnostics and decision-making systems and machine/deep learning in clinical setting. This is a valuable resource for clinicians, researchers, students and members of the biomedical and medical fields who want to learn more about the use of AI to improve patient care.

Natural Biopolymers for Drug Delivery thoroughly details the properties, benefits and challenges of using these biomaterials in drug delivery, with a strong focus on biocompatibility and reduction of unwanted interactions. An extensive range of natural biopolymers are explored, such as cellulose, chitosan, casein, gelatin, cashew gum, and many more. Biocompatibility, toxicity and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science and pharmacology, chemical engineering and clinical science.

Introduction to Diseases, Diagnosis, and Management of Dogs and Cats offers an informative and practical resource for an in-depth understanding of the full range of clinical and infectious diseases that occur in dogs and cats. It provides systematic coverage on the pathogenesis of disease, disease manifestation, diagnosis, treatment, therapeutic management, and prevention. Organized into three main sections, the book begins with an overall introduction and general discussion on the diagnosis and management of clinical and infectious diseases. This section examines the biological systems of dogs and cats, covers clinical examinations and diagnosis methods, specimen collection, nutritional strategies, and health maintenance. Section 2 goes on to discuss a range of clinical diseases that can affect the health of dogs and cats which includes diseases that impact major systems in the body like the cardiovascular, respiratory, gastrointestinal, reproductive, endocrine, nervous, and urinary systems to name a few. It also delves into autoimmune conditions, behavioral orders, and common toxicological phenomenon that occur in dogs and cats and offers strategies for pain management and therapeutic drug intervention. Section 3 rounds out the book with coverage of bacterial, fungal, viral, and parasitic infectious diseases. It explains the pathogenesis of disease, evaluation of the disease, identification of the pathogens and their severity to animals, disease manifestation in the animal, and preventive and treatment strategies to counteract the etiopathogenesis caused by several types of pathogens. With contributions from experts in the field, Introduction to Diseases, Diagnosis, and Management of Dogs and Cats features the latest advanced veterinary research for researchers, clinicians, and students engaged in researching and treating diseases in dogs and cats.

Biotechnology of Emerging Microbes: Prospects for Agriculture and Environment provides the latest developments of leading biotechnologists and bioengineers. The book covers various aspects of microbes mediated rhizosphere, biosphere, environmental, and ecosystem biotechnology, and focuses on the restoration and management of the rhizosphere, the biosphere, and the ecosystem with microbes for a sustainable future. It is designed to address various technical and application details of microorganisms and their products in biotechnology and bioengineering approaches. Users will find up-to-date knowledge that is beneficial to beginners, researchers, students, scientists, engineers, and industry stakeholders who can support the management of ecosystems through the use of microbes. Planet Earth is undergoing an accelerated process of change associated with a wide range of anthropogenic phenomena. The future of these changes is uncertain, but there is general agreement that this negative development might be detrimental to our own survival. Although different environmental engineering strategies have been developed, none of them seem to address carbon dioxide accumulation, biosphere, and ecosystem safety. The rapidly increasing potential for the development of living systems through the biotechnology and bioengineering of microbes is a sustainable alternative to address safety issues.

Precision Nutrition: The Science and Promise of Personalized Nutrition and Health organizes and integrates information on the diverse special areas of scientific expertise involved in Precision Nutrition in order to inform health professionals and inspire researchers to advance this field while applying the general principles into health care and medical research now. Broken into three sections, this book addresses the fundamentals of precision nutrition, applications of precision nutrition in health and disease, and the future directions of precision nutrition. Nutrition scientists, geneticists, physicians, dietitians, postdoctoral fellows, and epidemiologists seeking to understand Precision Nutrition will benefit from this timely reference. .

Hydrological Drought: Processes and Estimation Methods for Streamflow and Groundwater, Second Edition provides a comprehensive review of processes and estimation methods for streamflow and groundwater drought. It includes a qualitative conceptual understanding of drought features and processes, a detailed presentation of estimation methods and tools, practical examples and impacts relevant for operational practice.The drought phenomenon and its diversity across the world are illustrated using a global set of daily streamflow series, whereas regional and local aspects of drought are studied using a combination of hydrological time series and catchment information. Hydrological Drought: Processes and Estimation Methods for Streamflow and Groundwater, Second Edition concludes with human impacts, including climate change impacts on drought, drought forecasting and early warning and examples of procedures on how to manage water during drought. The majority of the examples are taken from regions where the rivers run most of the year, but not exclusively. The material presented ranges from well-established knowledge and analysing methods to recent developments in drought research. Its nature varies accordingly, from a more traditional textbook and clear overview to that of a research paper, which introduces recent approaches and methodologies for drought analysis.

pH Deregulation as the Eleventh Hallmark of Cancer presents key concepts about pH deregulation in a concise and straight-forward manner. The book discusses topics such as pH regulation and metabolism, sodium hydrogen exchanger, monocarboxylate transporter, V-ATPase proton pump, carbonic anhydrases, and voltage gated sodium channels. In addition, it covers clinical and therapeutic implications and future perspectives. This is a valuable resource for researchers, oncologists, students and members of the biomedical and medical fields who want to learn more about the role of pH deregulation in cancer treatment. pH deregulation can improve the outcome of classical treatments without adding toxicity to them, and the book shows that treating the pH peculiarities of cancer is simple and can be performed with existing drugs. Based on the classification of tumor malignancy in ten hallmarks, the authors put pH deregulation at the spotlight and separated from metabolic reprogramming due to its impact on all other hallmarks, proposing it as an additional characteristic to evaluate and fight cancer.

The Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy. This second edition of Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers a thorough, timely discussion of ethical issues raised by the latest genetic and genomic technologies applied in human reproductive and prenatal medicine, providing practical recommendations, guidelines, and algorithms to support ethical clinical practice. Here, international experts consider the ethics of technologies from preconception carrier screening to genetic engineering, CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction, and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Throughout the book, contributors adopt a global, holistic perspective on applied challenges and the moral questions around the implementation of genetic reproductive technologies. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors, and graduate and medical students.This fully updated second edition examines new developments in the field, tackling ethical aspects of organoid development, recent advances in pharmacogenomics, direct-to-consumer genetic testing, and genetic engineering.

Overexpression of receptor tyrosine kinases (RTKs) has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders. Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing central nervous system (CNS), adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclerosis, and psychiatric disorders including, anxiety, depression, alcohol use disorder, and schizophrenia. In addition, the book discusses the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders.

QSAR in Safety Evaluation and Risk Assessment provides comprehensive coverage on QSAR methods, tools, data sources, and models focusing on applications in products safety evaluation and chemicals risk assessment. Organized into five parts, the book covers almost all aspects of QSAR modeling and application. Topics in the book include methods of QSAR, from both scientific and regulatory viewpoints; data sources available for facilitating QSAR models development; software tools for QSAR development; and QSAR models developed for assisting safety evaluation and risk assessment. Chapter contributors are authored by a lineup of active scientists in this field. The chapters not only provide professional level technical summarizations but also cover introductory descriptions for all aspects of QSAR for safety evaluation and risk assessment.

Flood Forecasting: A Global Perspective, Second Edition covers hydrologic forecasting systems on both a national and regional scale. This updated edition includes a breakdown by county contribution and solutions to common issues with a wide range of approaches to address the difficulties inherent in the development, implementation and operational success of national-scale flood forecasting systems. Special attention is given to recent advances in machine learning techniques for flood forecasting. Overall, the information will lead to improvements of existing systems and provide a valuable reference on the intricacies of forecast systems in different parts of the world.