Books published by Elsevier Science & Technology

Welding and Joining of Advanced High Strength Steels (AHSS): The Automotive Industry discusses the ways advanced high strength steels (AHSS) are key to weight reduction in sectors such as automotive engineering. It includes a discussion on how welding can alter the microstructure in the heat affected zone, producing either excessive hardening or softening, and how these local changes create potential weaknesses that can lead to failure. . This text reviews the range of welding and other joining technologies for AHSS and how they can be best used to maximize the potential of AHSS.

Individualized cancer chemotherapy (ICC) has been designed to meet the requirement of selecting anticancer drugs in clinics and attracting increasing attentions in medical circle and will show more beneficial outcome in the future if we stick on these researches. Personalized Cancer Chemotherapy addresses and reviews this issue by discussing many existing specific strategies of ICC, including drug sensitivity testing, cancer biomarker detections, cancer biomarker-oriented therapy, anticancer drug pharmacogenetics, cancer metastasis therapy, anticancer drug combinations, assistant therapy, mathematics, and computational analysis of cancer malignancy and drug responses, cost effective and finally studies of relationship between different ICC strategies. The relationship between drug response and these techniques or methods is in-depth analyzed, discussed and highlight. Many longstanding key debates and future trends are also intensively discussed, highlighted and debuted with new twists.

Monoclonal antibodies (MAbs) are currently the major class of protein bio therapeutic being developed by biotechnology and pharmaceutical companies. Monoclonal Antibodies discusses the challenges and issues revolving around development of a monoclonal antibody produced by recombinant DNA technology into a therapeutic agent.This book covers downstream processing which includes design of processes to manufacture the formulation, formulation design, fill and finish into closure systems and routes of administration. The characterization of the final drug product is covered where the use of biophysical methods combined with genetic engineering is used to understand the solution properties of the formulation. The latter has become very important since many indications such as arthritis and asthma require the development of formulations for subcutaneous delivery (SC). The development of formulations for IV delivery is also important and comes with a different set of challenges. The challenges and strategies that can overcome these limitations are discussed in this book, starting with an introduction to these issues, followed by chapters detailing strategies to deal with them. Subsequent chapters explore the processing and storage of mAbs, development of delivery device technologies and conclude with a chapter on the future of mAbs in therapeutic remedies.

This book critically reviews the fundamental principles, systems, oxygen carriers and carbon dioxide carriers relevant to chemical looping and combustion.

Annual Reports in Computational Chemistry provides timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists.

In the central nervous system, extracellular matrix (ECM) molecules, including hyaluronic acid, chondroitin and heparan sulfate proteoglycans, tenascins, reelin and agrin, along with their remodelling enzymes, such as neurotrypsin, neuropsin, plasminogen activators, and metalloproteinases, are secreted by neural and non-neural cells into the extracellular space to form the ECM and signal via ECM receptors. Despite recent advances in the ECM field, the importance of neural ECM for physiological and pathological processes is currently less widely recognized than that of other CNS elements. This book will enlighten recent progress in our understanding of mechanisms by which neural ECM, its receptors and activity-dependent ECM remodeling regulate neural development, synaptic plasticity, and contribute to pathological changes in the brain. In the first part, the roles of ECM signaling and proteolytic modification of ECM in neurogenesis, neural migration, axonal pathfinding, synaptogenesis, synaptic and homeostatic plasticity will be discussed. The second part will focus on the emerging ECM-dependent mechanisms associated with CNS injury, epilepsy, neurodegenerative and neuropsychiatric diseases. For further development of neural ECM field, a very important contribution is the third part of the book, which is devoted to neural ECM-targeting tools and therapeutics. The concluding fourth part will highlight advances in development of artificial ECM and ECM-based systems suitable for multisite recording and stimulation of neural cells.

Respiration is one of the most basic motor activities crucial for survival of the individual. It is under total control of the central nervous system, which adjusts respiratory depth and frequency depending on the circumstances the individual finds itself. For this reason this volume not only reviews the basic control systems of respiration, located in the caudal brainstem, but also the higher brain regions, that change depth and frequency of respiration. Scientific knowledge of these systems is crucial for understanding the problems in the many patients suffering from respiratory failure.

The Side Effects of Drugs Annual was first published in 1977. It has been continually published since then as a yearly update to the voluminous encyclopedia Meyler's Side Effects of Drugs. Each new Annual continues to provide clinicians and medical investigators with a reliable and critical yearly survey of new data and trends in the area of adverse drug reactions and interactions. An international team of specialists has contributed to the informative Annual by critically interpreting it and by pointing to whatever is misleading.

R is open source statistical computing software. Since the R core group was formed in 1997, R has been extended by a very large number of packages with extensive documentation along with examples freely available on the internet. It offers a large number of statistical and numerical methods and graphical tools and visualization of extraordinarily high quality. R was recently ranked in 14th place by the Transparent Language Popularity Index and 6th as a scripting language, after PHP, Python, and Perl. The book is designed so that it can be used right away bynovices while appealing to experienced users as well.Each article begins with a data example that can be downloaded directly from the R website. Data analysis questions are articulated following the presentation of the data. The necessary R commands are spelled out and executed and the output is presented and discussed. Other examples of data sets with a different flavor and different set of commands but following the theme of the article are presented as well. Eachchapter predents a hands-on-experience. R has superb graphical outlays and the book brings out the essentials in this arena. The end user can benefit immensely by applying the graphics to enhance research findings. The core statistical methodologies such as regression, survival analysis, and discrete data are all covered.

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.

The Handbook on the Physics and Chemistry of Rare Earths is a continuous series of books covering all aspects of rare earth science - chemistry, life sciences, materials science, and physics. The main emphasis of the Handbook is on rare earth elements [Sc, Y and the lanthanides (La through Lu)] but whenever relevant, information is also included on the closely related actinide elements. The individual chapters are comprehensive, broad, up-to-date critical reviews written by highly experienced invited experts. The series, which was started in 1978 by Professor Karl A. Gschneidner Jr., combines and integrates both the fundamentals and applications of these elements and now publishes two volumes a year.

Over the years, there has been increasing focus on developing the processes and technologies for the conversion of biomass to liquid and gaseous fuels and chemicals, in particular to develop low-cost technologies. This book provides information and technological perspective on this topic.

The Integrated Ocean Drilling Program (IODP: 2000-2013) has provided crucial records of past and present processes and interactions within and between the biosphere, cryosphere, atmosphere, hydrosphere and geosphere. Research in IODP encompasses a wide range of fundamental and applied issues that affect society, such as global climate change, biodiversity, the origin of life, natural hazards involving the study of earthquakes processes, and the internal structure and dynamics of our planet.This compilation of major findings from the 2003-2013/14 phase of IODP, focusing on scientific results rather than description of data acquisition and early inferences, provides invaluable information. Anyone wondering what scientific drilling can achieve will gain quick understanding of the range of questions that are uniquely addressed with this methodology and the ways these data dovetail with other regional information. The excitement of breakthrough findings that occasionally accompanies a drilling project will be evident. IODP obtained unique records from the global ocean basins during the 2003-2013 program phase. This book highlights findings inthree theme areas: Subseafloor life and the marine biosphere; Earth's changing environments; and Dynamics of the solid Earth. Each core or borehole log provides a window revealing insights that no other data achieve.

Plasmonics is entering the curriculum of many universities, either as a stand alone subject, or as part of some course or courses. Nanotechnology institutes have been, and are being, established in universities, in which plasmonics is a significant topic of research. Modern Plasmonicsbook offers a comprehensive presentation of the properties of surface plasmon polaritons, in systems of different structures and various natures, e.g. active, nonlinear, graded, theoretical/computational and experimental techniques for studying them, and their use in a variety of applications.

Particle formation with supercritical fluids is a promising alternative to conventional precipitation processes as it allows the reduction of particle size and control of morphology and particle size distribution without degradation or contamination of the product. The book comprehensively examines the current status of research and development and provides perspectives and insights on promising future directions. . The introduction to high pressure and high temperature phase equilibria and nucleation phenomena provides the basic principles of the underlying physical and chemical phenomena,allowing the reader an understanding of the relationship between process conditions and particle characteristics. . Bridging the gap between theory and application, the book imparts the scientific and engineering fundamentals for innovative particle formation processes. The interdisciplinary "modus operandi" will encourage cooperation between scientists and researchers from different but complementary disciplines.

Essentials of Vehicle Dynamics explains the essential mathematical basis of vehicle dynamics in a concise and clear way, providing engineers and students with the qualitative understanding of vehicle handling performance needed to underpin chassis-related research and development.Without a sound understanding of the mathematical tools and principles underlying the complex models in vehicle dynamics, engineers can end up with errors in their analyses and assumptions, leading to costly mistakes in design and virtual prototyping activities. Author Joop P. Pauwelussen looks to rectify this by drawing on his 15 years¿ experience of helping students and professionals understand the vehicle as a dynamic system. He begins as simply as possible before moving on to tackle models of increasing complexity, emphasizing the critical role played by tire-road contact and the different analysis tools required to consider non-linear dynamical systems.Providing a basic mathematical background that is ideal for students or those with practical experience who are struggling with the theory, Essentials of Vehicle Dynamics is also intended to help engineers from different disciplines, such as control and electronic engineering, move into the automotive sector or undertake multi-disciplinary vehicle dynamics work.

The perfect guide for veteran structural engineers or for engineers just entering the field of offshore design and construction, Marine Structural Design Calculations offers structural and geotechnical engineers a multitude of worked-out marine structural construction and design calculations. Each calculation is discussed in a concise, easy-to-understand manner that provides an authoritative guide for selecting the right formula and solving even the most difficult design calculation. . Calculation methods for all areas of marine structural design and construction are presented and practical solutions are provided. Theories, principles, and practices are summarized. The concentration focuses on formula selection and problem solving. A "quick look up guide¿, Marine Structural Design Calculations includes both fps and SI units and is divided into categories such as Project Management for Marine Structures; Marine Structures Loads and Strength; Marine Structure Platform Design; and Geotechnical Data and Pile Design. The calculations are based on industry code and standards like American Society of Civil Engineers and American Society of Mechanical Engineers, as well as institutions like the American Petroleum Institute and the US Coast Guard. Case studies and worked examples are included throughout the book.

The theme of this volume is big data in ecology.

Takes the reader behind the scenes of 3GPP and provides an understanding of the principles, the steps in the standard's evolution, and the motivations behind the development of standardized features. This book covers topics such as multi-carrier features and operation, interface architecture, heterogeneous networks and HSPA system performance.

Analytical nanoscience and nanotechnology is a growing topic that is expected to have a great impact in the field of analytical chemistry. Many of the exceptional properties of gold nanoparticles make them suitable for different analytical applications and these applications allow extrapolations for their use in other fields as well. In analytical chemistry gold nanoparticles play two main roles, namely: i) As target analytes in the realm of the analysis of the nanoworld; and ii) As tools to improve analytical processes, such as the use of gold nanoparticles as components of electrodes, in spectroscopic techniques and (bio)chemical sensors and lateral flow sensors. This book is a comprehensive review of the role of gold nanoparticles in analytical nanoscience and nanotechnology, with chapters devoted to their synthesis, physico-chemical characteristics, derivatization and potential toxicity. The main microscopic, spectroscopic and separation techniques for the characterization are reviewed as well as the developments for their determination in environmental, biological and agrifood samples.

High-technology and environmental applications of the rare-earth elements (REE) have grown dramatically in diversity and importance over the past four decades. This book provides a scientific understanding of rare earth properties and uses, present and future. It also points the way to efficient recycle of the rare earths in end-of-use products and efficient use of rare earths in new products. Scientists and students will appreciate the book's approach to the availability, structure and properties of rare earths and how they have led to myriad critical uses, present and future. Experts should buy this book to get an integrated picture of production and use (present and future) of rare earths and the science behind this picture. This book will prove valuable to.non-scientists as well in order to get an integrated picture of production and use of rare earths in the 21st Century, and the science behind this picture.

Electricity from renewable sources of energy is plagued by fluctuations (due to variations in wind strength or the intensity of insolation) resulting in a lack of stability if the energy supplied from such sources is used in `real time¿. An important solution to this problem is to store the energy electrochemically (in a secondary battery or in hydrogen and its derivatives) and to make use of it in a controlled fashion at some time after it has been initially gathered and stored. Electrochemical battery storage systems are the major technologies for decentralized storage systems and hydrogen is the only solution for long-term storage systems to provide energy during extended periods of low wind speeds or solar insolation. Future electricity grid design has to include storage systems as a major component for grid stability and for security of supply. The technology of systems designed to achieve this regulation of the supply of renewable energy, and a survey of the markets that they will serve, is the subject of this book. It includes economic aspects to guide the development of technology in the right direction.