Books published by Elsevier Science

A Roadmap for the Comprehensive Assessment of Natech Risk: Management and Control of Technological Accidents Triggered by Natural Hazards in the Framework of Climate Change covers the latest advancements concerning the quantitative risk assessment and the management of cascading events involving technological accidents caused by natural hazards. The topic is meticulously covered, providing a description of past accidents, case-studies, and quantitative figures that allow for the identification of the most vulnerable plant elements, of the complex features of accident scenarios, and of their rising trend that is possibly related to factors as climate change and growing industrialization.Methodologies aiming at the assessment of the actual performance of safety barriers and safety systems during or immediately after the impact of a natural event are also presented. Recent tools and data supporting the quantitative assessment of these features in the overall assessment of Natech risk are reported, highlighting the similarities with other typologies of cascading accidents. Several case studies are presented in the book, and each methodology presented is provided with an illustrative case-study providing guidance to its application.

Fundamentals of Membrane Separation Technology provides a comprehensive and systematic introduction to this environmentally-friendly separation process. Using a structured format that promotes comprehension and implementation, each chapter provides overviews, principles, materials, preparation, and industrial applications. Each chapter then concludes with future prospects, references, and end-of-chapter exercises. Written for students and professionals, this book is an ideal reference for those who wish to better understand the fundamentals and applications of membrane technology.

Wetlands for Water Pollution Control, Third Edition, formerly known as Wetland Systems to Control Urban Runoff, covers broad water and environmental engineering aspects relevant for the drainage and treatment of stormwater and wastewater, providing a descriptive overview of complex 'black box' treatment systems and general design issues involved. Fundamental science and engineering principles are explained to address the student and professional market. Standard and novel design recommendations for predominantly constructed wetlands and related sustainable drainage systems are also provided to account for interests of professional engineers and environmental scientists. Users will find the latest research in wastewater treatment and runoff control presented in a manner that is ideal for academics, senior consultants, final year and postgraduate students, and graduate engineers, respectively.

Fragile X and Related Autism Spectrum Disorders, Volume 172 in the International Review on Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on The dopamine hypothesis of Autism Spectrum Disorder: a comprehensive analysis of the evidence, A Review of the Use of Psychotropic Medication to Address Challenging Behavior in Neurodevelopmental Disorders, Lipid metabolism alterations in fragile X syndrome and other neurodevelopmental disorders, Genesis, modelling and methodological remedies to autism heterogeneity, Toward an Understanding of the Role of the Exposome on Fragile X Phenotypes, Glial-mediated dysregulation of neurodevelopment in Fragile X Syndrome, and more.

Solid State Physics, Volume 74, the latest release in this serial that highlights new advances in the field, presents interesting chapters written by an international board of authors.

Natural Products, Volume 61 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters on Chemical evolution of natural product structure for drug discovery, Fungal Metabolites, Polypharmacology of Natural Products, Glycopeptide Antibiotics, and Natural products-based drug discovery for the CNS.

P450 Enzymes, Volume 692 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release cover Non-natural P450 reaction (carbene/nitrene), Non-natural P450 reaction (atom transfer radical cyclization), P450 fusion for biocatalysis, P450 fingerprinting for biocatalytic oxidation, Fungal peroxygenase, Fungal peroxygenase, Anti-Markovnikov P450 oxygenase (AmOX), Fungal P450, Unusual P450 chemistry from fungal sources, CASTing for P450 biocatalysis, and P450 in C-C coupling of cyclic dipeptides with nucleobases.

The Enzymes, Volume 54 highlights new advances in enzymes, with new chapters on a variety of topics, including the History of The Enzymes, Impact of The Enzymes in chronicling biochemical processes and pathways, Metabolism and Catalysis, Mitochondrial ATP synthase, The respiratory chain, A century of mitochondrial research, Five decades of metalloenzymology, Mechanisms of catalysis, Mitochondrial fatty acid synthesis and associated processes, Signaling, MAPK cascades: Origins, mechanisms and current status, Sphingolipids: From structural components to signaling hubs, Protein Homeostasis and Hydrolysis, Mitochondrial AAA+ proteases, Hsp70 and JDP proteins: structure-function perspective on molecular chaperone activity. Other sections cover DNA Replication and Repair, Structure-function studies of DNA replication proteins, and Helicases required for nucleotide excision repair.

Immunogenetics: A Molecular and Clinical Overview: Immunogenetic Factors and Signaling Pathways in Recurrent Miscarriage, Volume Four provides an overview of the scientific knowledge, achievements, and findings in the field of immunogenetics of recurrent pregnancy loss. With a strong focus on the role immune cells can play in recurrent pregnancy loss, the book also examines immune therapeutic aspects. In seventeen chapters, the book describes the roles of several different signaling pathways and the role of JLA and microRNAs in recurrent pregnancy loss. Several chapters are dedicated to the role autoimmune antibodies play in recurrent pregnancy loss. This book is a valuable resource for health professionals, scientists, researchers, and all those who wish to broaden their knowledge in the allied field.

Immunogenetics: A Molecular and Clinical Overview, Vol. 3, Immune Cells and Immunotherapeutics in Recurrent Miscarriage provides an overview of the scientific knowledge, achievements, and findings in the field of immunogenetics of recurrent pregnancy loss. With a strong focus on the role immune cells can play in recurrent pregnancy loss, the book also examines immune therapeutic aspects. In fifteen chapters, the book describes the roles of both helper cells, nature killer cells, lymphoid cells, regulatory cells and macrophages in recurrent pregnancy loss. In addition, it describes clinical outcomes of several therapies and gives insight into new treatments. This new release is a valuable resource for health professionals, scientists and researchers, and all those who wish to broaden their knowledge in the allied field.

Neurotoxicity of Halogenated Organic Compounds, Volume 10 covers three groups of Halogenated Organic Compounds (Chlorinated, Brominated, and Fluorinated Compounds) that are legacy and emerging contaminants, providing background information, characteristics, physicochemical properties, environmental contamination, and human exposure. Specific chapters covered in this release include Perspective on Halogenated Organic Compounds, The Neurotoxicity of Polychlorinated Biphenyls (PCBs), Neuroendocrine Effects of Polychlorinated Biphenyls (PCBs), Mechanisms of PCB Neurotoxicity: AHR and THR Dogma meet RYR reality, Microbiome and the Neurotoxicity of Brominated Flame Retardants (BFRs), and much more. Other chapters cover Neuroendocrine Effects of Brominated Flame Retardants (BFRs), Focused on Polybrominated Diphenyl Ethers (PBDEs), Neurochemical Effects of Halogenated Organic Compounds: Possible Mode(s) of action and Structure-Activity Relationships, The Neurotoxic Effects of Perfluoroalkyl Substances (PFAS) in Animal Models and Human Cohorts, Neurochemical Mechanisms of Perfluoroalkyl Substances (PFAS) Neurotoxic Action, and Future Directions and Regulatory aspects of Halogenated Organic Compounds.

International Review of Cell and Molecular Biology, Volume 381 highlights new advances in the field, with this new volume presenting interesting topic on Overview of Inflammatory Breast Cancer: Updates.

Social and Communicative Functioning in Populations with Intellectual Disability: A Developmental Perspective, Volume 65 in the International Review of Research in Developmental Disabilities series, focuses on social and communicative functioning with a particular emphasis on people with intellectual disability. The volume brings together international researchers across disciplines to highlight innovative approaches to holistically describe social and communicative abilities in this population including teleassessment, self-report, and community-engaged research designs. Through a lifespan approach, key issues are raised related to social and communicative functioning across a range of communication modalities from infancy through adulthood. Additional chapters cover Adaptation of in-person tools for remote assessment of infants and toddlers with social communication concerns in community-based settings, Measuring social communication in people with ID who use minimal speech: Differences across the lifespan, and Social Inclusion of Adults with IDD: Toward Belonging, Building a Life: Examining the advocacy and social experiences of students with IDD in inclusive postsecondary education.

Stratigraphy and Timescales, Volume Eight in the Advances in Sequence Stratigraphy series, covers research in stratigraphic disciplines, including recent developments in the geosciences. This fully commissioned publication aims to foster and convey progress in stratigraphy with its inclusion of a variety of topics, including The fusulinids of a carbonate platform in Middle Permian Maokou Formation (Guadalupian) in eastern Sichuan Basin, China, Provenance of the Neogene sedimentary rocks of Sabah: the Kudat Formation, circular basins and the Crocker Unconformity revisited, The Neogene West Baram Delta, Ages and provenance of sedimentary rocks from Northwest Sulawesi and East Kalimantan: the Neogene Mahakam Delta, and much more.

Dystonia, Volume 169, the latest release in the International Review of Neurobiology serial, highlights new advances in the field with this new volume presenting interesting chapters on topics including Clinical Features and the Science of Classification, What Can Epidemiological Studies Tell us About the Neurobiology of Dystonia, Dystonia Genes and Their Biological Pathways, Functional Anatomy of Dystonia, Physiology of Dystonia: Human Studies, Physiology of Dystonia: Animal Studies, Experimental Pharmacology: Targeting Neurotransmitters, Experimental Pharmacology: Targeting Metabolic Pathways, Adult-Onset Focal Dystonias: One Biology or Many?, Early-Onset Inherited vs Late-Onset Idiopathic Dystonias: Same or Different Biological Mechanisms?, and much more.

Biofilms, Volume 53 in the ongoing Methods in Microbiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, including Monospecies and polymicrobial biofilms in static and flow environment, Methods used to study biofilms, Spatial analysis of bacterial biofilms, Biofilm grown in bioreactors, Single-cell analysis of subpopulations within biofilms using microscopy, flow cytometry, and imaging flow cytometry, Microscopy analysis of biofilm-mineral interactions or mineral formation within biofilms, Bacterial biofilms as an essential component of rhizosphere plant-microbe interactions, Studying Gene Expression in Biofilms, and more.

ZIP Metal Ion Transporters, Volume 684 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Biochemistry, Biophysics and Structural Biology, Structure determination of a bacterial ZIP in lipidic cubic phase, Cell-based metal transport assay for animal and plant ZIPs, Measurement of metal binding affinity and transport activity in ZIP transporters using spectroscopic methods, Considerations in production of the (prokaryotic) ZIP family transporters for structural and functional studies, Metal-protein interactions investigated using model systems: thermodynamic, spectroscopic and computational methods, and more. Additional chapters cover Getting Zinc Into and Out of Cells, In-silico modeling of ZIP9 (TBD), Cellular Function and Regulation, Methods to visualize zinc transporter proteins of the SLC39A family in cells, Assessing metal ion transporting activity of ZIPs: intracellular zinc and iron detection, In vitro studies for studying manganese transport and homeostasis, and much more.

Phage Therapy - Part B, Volume 201 covers bacteriophage and their isolation, screening, synthetic phage, diagnostics, directed evolution, host interaction, and more. The book's aim is to highlight a number of aspects of phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform research. Sections cover Phages for the treatment of Pseudomonas aeruginosa infection, Phage for the treatment of Vibrio cholerae infection, Phages for the treatment of Mycobacterium species, Phage therapy for gut microbiome, Phages as delivery vehicles, Phage display, Unlocking the potential of Phages: Innovative Approaches to harnessing Bacteriophages as Diagnostic Tools for Human Diseases, and more. Other sections explore Phage display and human disease detection, Bacteriophage as Cargo and its application in nanomedicine, Phage for drug delivery vehicles, Genome editing for phage design and uses for therapeutic applications, Phage for cancer therapy, and Phage for regenerative medicine and cosmetics.

Photoelectrochemical Engineering for Solar Harvesting: Chemistry, Materials, Devices provides an up-to-date appraisal of the photon engineering of innovative catalysts for solar energy harvesting. This book analyzes the overall progress, potential challenges, and the industrialization of new catalysts in the near future. The primary emphasis is on experimental approaches from materials synthesis to device applications, however, there is also an introduction to relevant photochemistry concepts. This book is suitable for materials scientists and chemists who, through the use of photonics, are in continuous pursuit of improving the efficiencies of different devices used to capture solar energy for the generation of sustainable fuel. Sunlight-driven fuel synthesis is the most sustainable and potentially economical option for producing energy vectors through water splitting. Thus, this book focuses on the design of photocatalysts and water oxidation catalysts, as artificial photosynthesis and hydrogen fuel production via water oxidation (in place of fossil fuels) are two promising approaches towards renewable energy.

Recapitulating The Stem Cell Niche Ex Vivo, Volume Six in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Recapitulating the bone marrow stem cell niche ex vivo, The generation of the liver ex vivo, Recapitulating the thymic stem cell niche ex vivo, Recapitulating the intestinal epithelium stem cell niche ex vivo, Recapitulating the lung stem cell niche in vitro, Recapitulating mammary tissue in vitro, and Recapitulating muscle in vitro.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

Cilia Signaling in Development and Disease, Volume 155 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Cilia and mTOR signaling, Cilia and Kidney, Extraciliary functions of IFT proteins, Cilia and eye stem cells, Cilia and eye development, Cryo-EM/ET and cilia structure, and Control of protein and lipid composition of photoreceptor outer segments and the implications for eye diseases.

In this issue of Veterinary Clinics: Small Animal Practice, guest editor Dr. Joshua Stern brings his considerable expertise to the topic of Advancements in Companion Animal Cardiology. Cardiovascular disease of companion animals has seen a boom in research productivity and novel therapies that make the future of cardiac care very bright. In this issue, top experts highlight advances in diagnosis and treatment for common cardiac diseases such as hypertrophic cardiomyopathy, mitral valve degeneration, and dilated cardiomyopathy. Contains 12 relevant, practice-oriented topics including hypertrophic cardiomyopathy: advances in imaging and diagnostic strategies; the genetics of canine pulmonary valve stenosis; mitral valve repair: surgical outcomes and the rise of interventional options; the role of personalized medicine in companion animal cardiology; the role of point-of-care thoracic ultrasound in managing cardiac emergencies; and more.  Provides in-depth clinical reviews on advancements in companion animal cardiology, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Nanofluids for Large-Scale Industrial Applications examines the challenges and current progress towards large-scale industrial application of nanofluids, summarizing and bringing together varied current research strands and providing potential solutions pertaining to the scientific, economic, and social barriers that currently exist. Opening with an introduction to nanofluid synthesis, types, and properties, this book traverses the potential large-scale applications and commercialisation of nanofluids in industrial heating/cooling, solar energy systems, refrigeration systems, automotive systems, and various chemical processes and manufacturing systems. This book provides knowledge of a vast area of applications of nanofluids in industries. Thus, it also has potential to encourage and trigger the minds of researchers to discover more about nanofluids, investigate the gaps, overcome the challenges, and provide future directions for newer applications and develop nanofluids further. The book is written chiefly for graduate/postdoc level students and researchers/academics teaching or studying in chemical and thermal engineering and who are focused on heat transfer enhancement, thermal energy, nanofluids, and nano-enhanced energy systems such as solar thermal systems.

Spectroscopic Measurement: An Introduction to the Fundamentals, Second Edition contains the foundational topics associated with optical spectroscopic techniques, covering the basic theory of applied spectroscopy and presenting alternative approaches to understand physical processes. Electromagnetism, quantum mechanics, statistical mechanics, molecular spectroscopy, optics, and radiation form the foundations of the field are all thoroughly covered. On top of these rest the techniques applying the fundamentals, including Emission Spectroscopy, Laser Induced Fluorescence, and Raman Spectroscopy. This comprehensive and fully updated second edition includes additional coaching and covers new material online broadening, nonlinear techniques such as coherent anti-Stokes Raman spectroscopy, and more.Researchers not formally trained in these topics, but who apply spectroscopy in their work, will appreciate the detail contained in this book to ensure accuracy of their technique and/or to develop more sophisticated measurements.

Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development covers the most important efforts of scientists and engineers worldwide to accelerate the process of discovery, production, and eventual market penetration of more potent antimicrobial peptides. These efforts have been fueled by emerging technologies such as artificial intelligence and data science, molecular and CFD simulations, easy-to-use process simulation packages, microfluidics, 3D-printing, among many others. Such technologies can now be implemented and scaled up quickly and at relatively low cost in low-budget production facilities, critical to moving to sustainable and marketable products worldwide. Discovering novel antimicrobial peptides rationally and cost-effectively has emerged as one of the significant challenges of modern biotechnology. Thus far, this process has been tedious and costly, resulting in molecules with activities far below those needed to address the current challenge of microbial resistance to antibiotics that takes the lives of thousands of people around the world every year. Finally, the book also highlights how multidisciplinary teams have assembled to address the challenges of manufacturing, biological testing, and clinical trials to finally reach complete translation.

3-Membered Heterocycle Synthesis provides readers with detailed information about the synthesis of three-membered heterocyclic compounds. The book comprehensively describes three-membered heterocyclic compounds synthesis, allowing the audience to quickly assess possible synthetic approaches. Other sections discuss their unusual combination of synthetic flexibility, reactivity, and atom economy. The main challenge for synthetic chemists, both in academia and industry, is the search for efficient approaches to target molecules. This book presents several methodologies for the synthesis of three-membered heterocyclic compounds.

Agroforestry for Carbon and Ecosystem Management is a comprehensive overview of current research, issues, challenges, and case studies in the area of agroforestry. The book focuses specifically on carbon source-sink relationship and management through agroforestry practices with a goal of improving overall environmental sustainability. Through expert insights and case studies, the book promotes carbon management, greenhouse gas emission reduction, forest, and ecosystem services management, along with relevant sustainable approaches for natural resources conservation. Users will find insights into novel approaches for natural resource management, with specific attention given to technologies related to carbon capture and management. In addition, the book addresses the knowledge gap in relation to agroforestry, sustainability, and agroecosystem management and explores the application of remote sensing and geospatial technologies for agroforestry management.

Practical Design and Applications of Medical Devices focuses on devices which receive and transmit bioelectric signals, such as electrocardiograph, electrodes, blood flow, blood pressure, physiological effects and, in some cases, current flowing through the human body. This thorough guide for researchers and engineers in the field of biomedical and instrumentation engineering presents a streamlined medical strategy for designing these medical devices, sensors, and tools. It also promotes operational efficiency in the healthcare industry, with the goals of improving patient safety, lowering overall healthcare costs, broadening access to healthcare services, and improving accessibility.