Books published by Elsevier Science

Nongenetic Information and Evolution investigates the origin and nature of nongenetic information and its role in the mechanisms of evolutionary change. This book opens with an introduction to the theoretical background and forms of nongenetic information, alongside its relationship with genetic information. It then explores nongenetic information across the biological kingdoms, including animals, nonneural organisms, plants, and unicellulars. It also covers epigenetics as a form of nongenetic information, exploring DNA methylation, histone modifications, chromatin remodeling, and miRNA expression in this context. This book closes with a discussion of nongenetic information in evolution, considering evidence demonstrating its inheritance and hereditary impact. This book provides a detailed overview of the origin and evolutionary impact of nongenetic inheritance, delivering a basis for further understanding the occurrence of hereditary phenomena and transgenerational phenotypic changes that do not involve genes. This is a useful reference for researchers in the field of epigenetics, evolutionary biology, developmental biology, and cellular and molecular biology.

Brain and Organ Communication: Effects of Crosstalk on Neurophysiology examines the intricate relationship between the brain and other organ systems within the body. With an emphasis on homeostasis of these systems, this book also explores how various systems are related and affected by the brain injury or organ damage from a neurophysiological standpoint. This book will be most useful to researchers in neuroscience and graduate students studying neurophysiology. Those with an interest in endocrinology and clinicians in various branches of neuroscience and physiology will also find this book of interest.

mRNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of mRNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions. The book begins with foundational knowledge covering mRNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with mRNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome. The third section describes the current and future clinical applications of mRNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of mRNA vaccines for COVID-19 and other infectious diseases, as well as mRNA's role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of mRNA therapeutics for protein replacement therapy and gene-editing, as well as newer mRNA constructs, including self-amplifying mRNA. The final section addresses the safety and regulatory considerations of mRNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness. Currently, mRNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of mRNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of mRNA's role in therapeutics. This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences.

Nanostructured Lithium-ion Battery Materials: Synthesis and Applications provides a detailed overview of nanostructured materials for application in Li-ion batteries, supporting improvements in materials selection and battery performance. The book begins by presenting the fundamentals of Lithium-ion batteries, including electrochemistry and reaction mechanism, advantages and disadvantages of Li-ion batteries, and characterization methods. Subsequent sections provide in-depth coverage of a range of nanostructured materials as applied to cathodes, electrolytes, separators, and anodes. Finally, other key aspects are discussed, including industrial scale-up, safety, life cycle analysis, recycling, and future research trends. This is a valuable resource for researchers, faculty, and advanced students across nanotechnology, materials science, battery technology, energy storage, chemistry, applied physics, chemical engineering, and electrical engineering. In an industrial setting, this book will be of interest to scientists, engineers, and R&D professionals working with advanced materials for Li-ion batteries and other energy storage applications.

COVID-19 and the Cardiovascular System: From Pathophysiology to Clinical Management comprehensively covers COVID-19’s impact on the cardiovascular system. Coverage includes the pathophysiology, clinical manifestations, diagnostic approach, treatment options, and clinical outcomes of patients presenting with COVID-19 with cardiac involvement. In a concise but comprehensive manner, the book's content reviews the epidemiology, risk factors, pathophysiology of COVID-19, cardiovascular clinical manifestations, non-invasive and invasive diagnostic evaluation, therapeutic options, outcomes data, role of the COVID-19 vaccine, and long-term outcomes/management.This is the perfect reference for basic and clinical researchers in cardiovascular medicine as well as practicing clinical cardiologists who are dealing with COVID-19 patients with cardiac involvement.

Primer to Neuromorphic Computing highlights critical and ongoing research into the diverse applications of neuromorphic computing. It includes an overview of primary scientific concepts for the research topic of neuromorphic computing, such as neurons as computational units, artificial intelligence, machine learning, and neuromorphic models. It also discusses the fundamental design method and organization of neuromorphic architecture. Hardware for neuromorphic systems can be developed by exploiting the magnetic properties of different materials. These systems are more energy efficient and enable faster computation . Magnetic tunnel junctions and magnetic textures can be employed to act as neurons and synapses. Neuromorphic systems have general intelligence like humans as they can apply knowledge gained in one domain to other domains.

Theranostics Nanomaterials in Drug Delivery presents the most recent advances in the development of theranostic nanomaterials for drug delivery. This book compiles reports and studies on the latest changes and improvements of theranostic nanocarriers such as nanoemulsions, liposomes, exosomes, polymeric micelles, PLGA nanoparticles, chitosan nanoparticles, dendrimer, quantum dots, silica nanoparticles, gold nanoparticles, silver nanoparticles, magnetic nanoparticles, and many more, all of which can help in the sensitive diagnosis, precise targeting, and efficient and controlled delivery of nanomaterials to control various diseases at different clinical stages. Theranostics nanomaterials in drug delivery will serve as a solid foundation and reference for pharmaceutical scientists, undergraduate and postgraduate students, researchers, and experts in the medical field involved in the development of advanced drug delivery systems.

Advances in Sustainable Applications of Microalgae discusses different mechanisms used by microalgae to treat various gaseous streams, wastewaters, and pollution bioremediation. In addition, the advantages of the application of microalgal biomass in the agricultural and food/feed sectors are presented and bioenergy from microalgae with a view to sustainability is explored. The present covers the use of microalgal cultures in various applications, such as: the treatment of gaseous streams by removing various contaminants, wastewater treatment through the removal of several pollutants, biomass valorization for agriculture purposes, bioenergy from microalgae, and industrial integration of all these processes in a biorefinery concept. Finally, the book emphasizes the importance of gathering scientific knowledge to overcome drawbacks related to microalgal production and develops the concept of biorefinery based on microalgal biomass for a more sustainable future.

Statistical Analysis for Civil Engineers: Mathematical Theory and Applied Experiment Design is a well-researched and topically organized reference book that guides its readers, both in academia and industry, to recognize how to describe unpredictable events in a quantitative way and to learn how these events can be incorporated into practical engineering analysis that facilitates data-driven problem solving and optimization-based decision-making.Written by experts in the field with a proven track record as educators and practicing consultancy specialists, this book has been developed in such a manner that it advances understanding of the mathematical theory underlying analytical methodology gradually. It also supports practical application through relevant worked examples in a variety of civil engineering branches, notably structural, materials, transportation, and geotechnical engineering. Through all stages of data analysis, numerical modeling and simulation, and implementation, the volume emphasizes the need to change the current perception with respect to the use of modern statistical techniques in the scientific as well as practical spheres of civil engineering.

Functional Foods: Principles and Technology, Second Edition covers the definition, history, and development trends of functional foods. Specifically, this updated edition discusses the chemistry of functional components and their physiological properties of functional foods, including antioxidants, dietary fiber, pre-, pro-, and paraprobiotics, symbiotics, and postbiotics, selected nutritional supplements, soy and soy foods, human milk biochemistry and infant formula, sports drinks chemistry, and formulation aspects. This book is sure to be of interest to food and nutrition researchers, pharmacologists, and those teaching and studying related fields.

Recent Developments and Innovations in the Sustainable Production of Concrete covers the various aspects of sources, materials, and waste products in concrete production, innovation in materials-new technological developments, and the upgradation of existing concrete production systems. Importantly, it covers the so-called EEE aspects (Economy, Energy, and Environment), not touched by other books. The books also highlights the sustainability aspects of concrete production when recycled materials are added. Case studies are used to demonstrate the practical aspect of concrete production, including the machine learning approach.

Polymer Gears discusses polymer gear design and their efficient mechanical properties, light weight, and low noise during operation. As plastic gears are replacing metallic gears in traditional and new applications, there is still lack of material characterization and complex relations between different geometric and operating parameters. Thus, polymer gear design remains an open challenge. This book serves as a comprehensive and professional guide on the topic, providing readers with current developments carried out in the field of plastic gears production, characterization, and applications. This will include material development, tribological properties, simulations, and processing methods.

Recent Developments of Geopolymer Materials: Processing and Characterisations focuses on the development, processing, and characterization of sustainable and eco-friendly materials, highlighting recent research developments in this field. The book covers the processing and characterization of geopolymers, incorporating green materials from waste and recycled materials specifically for construction applications, as well as advanced processing and characterization for a wide variety of applications. The book provides in-depth chapters on the development, processing, and characterization of sustainable and green materials with extensive uses, such as construction.It is divided into two sections: Development of Geopolymer Materials for Construction Applications and Advanced Processing and Characterization for Wider Applications, and will be a useful resource for academics, engineers, companies, and stakeholders in geopolymers from green materials for a variety of wide applications, including construction materials, ceramics, adsorbents, drilling properties, and simulation analysis.

Polymers for Oral Drug Delivery Technologies covers the fundamentals of oral drug delivery and various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. It presents the oral delivery¿of therapeutics for treating a number of diseases, along with the challenges of oral drug administration to assure a predictive and reproducible pharmacokinetic profile of active pharmaceutical ingredients (API).Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract.

Handbook of Neurodegenerative Disorders: Mechanism, Diagnostic and Therapeutic Advances provides a comprehensive review on the current biomedical studies aimed at identifying the underlying causes of neurodegeneration. This book reviews the most recent developments in molecular and cellular processes altered during neurodegeneration. Divided into four parts, the first covers the mechanism of cell death in neurodegeneration. The second section reviews the recent progress in gene and gene products in neurodegeneration, including Huntington's disease, Parkinson's disease, Friedreich' s ataxia, and spinal muscular atrophy. The final sections cover the current and future diagnostic techniques of neurodegenerative disorders along with therapeutic approaches.

Biofuels and Bioproducts from Lignocellulosic Materials: Biomaterials is Volume 3 of a comprehensive three-volume set that explores the various possibilities of adding value to lignocellulosic biomass materials by transforming them into bioproducts, biofuels and biomaterials. With an emphasis on microbial biotechnological solutions, each volume examines the use of renewable natural resources, agriculture waste management, and valorization of agro-wastes to sustainably produce energy and fuels, nutraceuticals and pharmaceuticals, chemicals, and biomaterials. Volume 3 addresses all aspects of biomaterials production from lignocellulosic materials. The book examines recent innovative approaches for conversion and assesses the role of engineered microorganisms and their mechanisms of action for biomaterials production. The opening chapter of the book reviews the properties, types, production, and applications of various biomaterials. Following this, readers will find critical reviews of the latest developments and step-by-step guidance on key processes and methods, including novel, eco-friendly methods for biomass conversion that reduce waste. Finally, dedicated chapters review the techno-economic and LCA of lignocellulosic biomass conversion into different biomaterials such as bio-adhesives, biopolymers, bio-packaging materials, bioplastics, and value-added functional biomaterials. Biofuels and Bioproducts from Lignocellulosic Materials: Volume 3: Biomaterials is a valuable reference for students, researchers, and professionals involved in processing lignocellulosic materials for the production of bioenergy, biomaterials, and bioproducts.

Advanced Transport Biofuels: Production, Economics, and Sustainability provides a comprehensive review of the latest in the global production, economics, and sustainability of advanced transport biofuels. Drawing upon the latest developments in academia and industry globally, the book reviews biofuels policy and the technoeconomics of biofuels production. The technical considerations in the combustion of biofuels are discussed alongside the latest lab-scale and industrial-level combustion property testing using biofuels and biojet fuels. Finally, a lifecycle analysis of biofuel production is conducted related to the sustainability issues in production. This is an invaluable review of the current state of the biofuels industry, policies, technologies, and economic and sustainability issues related to biofuels applications that will be of interest to graduate students and researchers involved in the development and implementation of alternative fuels in the transportation industry. The book will also be of interest to professional engineers and policymakers working in the automotive industry and involved in the application of alternative fuels.

Railway Noise and Vibration: Mechanisms, Modelling, and Means of Control, 2nd Edition provides a complete overview of the state of the art in rail noise and vibration theory and modelling. This book describes each source of noise and vibration, such as rolling noise, curve squeal, bridge noise, aerodynamic noise, ground vibration and ground-borne noise, and vehicle interior noise in a systematic way, covering relevant theoretical modelling approaches and their practical implementation, with extensive examples of noise control technology applied at source. Noise and vibration are key obstacles to further development of railway networks worldwide for high-speed intercity traffic, freight and suburban metros and light-rail systems. With noise problems all too often dealt with inefficiently due to a lack of understanding of the problem, this new edition is an invaluable reference for all those working with noise and vibration from railways, whether in industry, consultancy, or academic research.

Previous ed. published: Amsterdam; Boston: Elsevier, 2002, under title: Modelling in transport phenomena.

Organic Farming: Global Perspectives and Methods, Second Edition provides the core definition and concepts of organic farming, also addressing current challenges and goals. The book provides a comprehensive resource, from sustainability to influences on the ecosystem, including the significance of seed, soil, water and weed management, and other important aspects. In addition, it presents advancements in the field and insights on the future. This fully revised and updated edition expands coverage to include important economic considerations, understanding the influence of nanotechnology on organic farming, vertical farming, organic farming and livestock management, as well as the future of organic farming. Written by a team of global experts to provide current concepts of organic farming, this resource is valuable for researchers, graduate students, and post-doctoral fellows from academia and research institutions.

Applied Plastics Engineering Handbook: Processing, Sustainability, Materials, and Applications, Third Edition presents the fundamentals of plastics engineering, helping bring readers up-to-speed on new plastics, materials, processing and technology. This revised and expanded edition includes the latest developments in plastics, including areas such as biodegradable and biobased plastics, plastic waste, smart polymers, and 3D printing. Sections cover traditional plastics, elastomeric materials, bio-based materials, additives, colorants, fillers and plastics processing, including various key technologies, plastic recycling and waste. The final part of the book examines design and applications, with substantial updates made to reflect advancements in technology, regulations, and commercialization. Throughout the handbook, the focus is on engineering aspects of producing and using plastics. Properties of plastics are explained, along with techniques for testing, measuring, enhancing, and analyzing them. Practical introductions to both core topics and new developments make this work equally valuable for newly qualified plastics engineers seeking the practical rules-of-thumb they don't teach you in school and experienced practitioners evaluating new technologies or getting up-to-speed in a new field.

Functional Fillers: Chemical Composition, Morphology, Performance, Applications, Second Edition covers the structure, physical properties, electrical and magnetic properties, and applications of fillers. The book includes two sections, with the first part covering classic fillers, analyzing the current modifications in relation to composition and morphology, and enabling enhancements in properties and applications. The second part presents the new generation of fillers, which provide designers with exceptional properties not previously available. Applications discussed include lubricants, anti-corrosion, antimicrobial, and more. Renewable fillers and recycling of fillers are covered as well.

Databook of Plasticizers, Third Edition contains data on more than 300 of the most important generic and commercial plasticizers in use today. The data comes from a range of sources beyond plasticizers manufacturers, allowing for a detailed comparison of properties of different plasticizers. Over 100 different data fields are provided, from general information, such as molecular structure and formula, to physical properties, health and safety information, ecological properties, and recommendations regarding appropriate use and performance of each plasticizer. This data book is an essential resource for engineers, technicians and materials scientists responsible for specifying a plasticizer. The book has been updated to reflect the recent changes in plasticizer approvals for production of various materials, including chloroparaffins, refined oil derivatives, and phalates, and also includes data details on a range of new plasticizers that have recently gained market approval. It serves as an ideal companion to the Handbook of Plasticizers.

Molten Salt Reactors and Thorium Energy, Second Edition is a fully updated comprehensive reference on the latest advances in MSR research and technology. Building on the successful first edition, Tom Dolan and the team of experts have fully updated the content to reflect the impressive advances from the last 5 years, ensuring this book continues to be the go-to reference on the topic. This new edition covers progress made in MSR design, details innovative experiments, and includes molten salt data, corrosion studies and deployment plans. The successful case studies section of the first edition have been removed, expanded, and fully updated, and are now published in a companion title called Global Case Studies on Molten Salt Reactors. Readers will gain a deep understanding of the advantages and challenges of MSR development and thorium fuel use, as well as step-by-step guidance on the latest in MSR reactor design. Each chapter provides a clear introduction, covers technical issues and includes examples and conclusions, while promoting the sustainability benefits throughout.

Solvents are used in nearly all industries, from cosmetics to semiconductors, and from biotechnology research to iron and steel production. This book is a comprehensive and extensive textual analysis of the principles of solvent selection and use. It is a balanced presentation of solvent performance, processing characteristics, and environment and health issues. The book is intended to help formulators select ideal solvents, safety coordinators to protect workers, legislators and inspectors to define and implement technically correct public safeguards on solvent use, handling, and disposal. The volume begins with discussion of solvent use in over 30 industries, which are the main consumers of solvents. The analysis is conducted based on available data and contains information on the types (and frequently amounts) of solvents used and potential problems and solutions. This followed by discussion of residual solvents left in final products. The environmental impact of solvents, such as their fate and movement in water, soil and air, fate-based management of solvent containing wastes, and ecotoxicological effects are discussed. Practical guidance is also provided on immediate reaction to human solvent poisoning, persistence of symptoms of solvent exposure, and effects of solvents on various parts of the human body. These expert contributions should be frequently consulted by solvent users and agencies which are responsible for protection of people in industrial environments. Possibilities for solvent substitution are also discussed, with emphasis on supercritical solvents, ionic liquids, ionic melts, and agriculture-based products. Solvent recycling, removal from contaminated air, and degradation are covered.

Sample Handling and Trace Analysis of Pollutants: Innovations to Determine Organic Contaminants, Second Edition reviews the latest technologies and challenges in trace analysis of environmental pollutants, from selecting the right approach to tips for performing analytic procedures and measuring and reporting results. Written by internationally renowned experts in environmental analysis from 5 continents and edited by leaders in the field, this completely updated and revised volume presents the latest techniques developed over the past 10 years, such as high-resolution mass spectrometry, biosensors and imaging techniques. Important tools for problem-solving in the determination of environmental pollutants are also discussed.Chapters cover emerging pollutants in the environment, such as nanomaterials, microplastics, metabolites and/or transformation products and antimicrobial resistances. Specific sections describe field sampling techniques and sample preparation in environmental matrices: air, water, soil, sediment and biota, focus on passive samplers, cover the determination of these environmental contaminants based on analytical techniques, such as the use of gas chromatography and liquid chromatography coupled to mass spectrometry, immunoassays, and biosensors as well as advanced analytical methods such as imaging techniques.

Medical and Educational Needs for Autism aims to provide understanding and assistance to clinicians interacting with ASD patients and their caregivers. This book is divided into two clear sections, first the medical coverage and second, an educational section. The first section includes chapters on sleep disorders, feeding/nutrition concerns, and medication. The second section focuses on the education component which includes IEP processes and activities for daily living.

Finite Element Analysis of Polymers and its Composites offers up-to-date and significant findings on the finite element analysis of polymers and its composite materials. It is important to point out that to date there are no books that have been published on this concept. Thus, academicians, researchers, scientists, engineers, and students in the similar field will benefit from this highly applications-oriented book that summarizes the experimental, mathematical, and numerical analysis of polymers and composite materials through the finite element method. The book provides detailed and comprehensive information on mechanical properties, fatigue and creep behavior, thermal behavior, vibrational analysis, testing methods, and their modeling techniques. In addition, the book lists the main industrial sectors in which polymers and composite materials simulation is used, and their gains from it, including aeronautics, medical, aerospace, automotive, naval, energy, civil, sports, manufacturing, and even electronics.

Health and Environmental Effects of Ambient Air Pollution is part of a series of three volumes for Air Pollution, Human Health, and the Environment. Volume 1 discusses the adverse consequences of ambient air pollutants on human health, animals, plants, and structures. This book examines the production of ambient air pollutants in the environment. It begins with an overview of the classifications, sources, and occurrences of outdoor air pollutants. This book covers meteorological, climate, and topographical factors affecting air pollution, discusses how urbanization and industrialization affect air quality, and explores how climate conditions like global warming, acid rain, and airborne particulate matter impact human health. It also looks at epidemiology studies and socioeconomic aspects of outdoor air pollution, estimating health and cost effects, air quality indices, guidelines, standards, and information networks of ambient air pollutants. With contributors from experts in the field, this book is a valuable reference for academicians, researchers, and students in environmental health, public health, and occupational health, as well as environmental engineers, meteorologists, epidemiologists, medical researchers, and environmental toxicologists.

This book explores cutting-edge biocarbon polymer composites. The book brings together nine edited chapters that explore the development, properties, and applications of these eco-friendly materials, highlighting their potential to transform industries and reduce the environmental impact of traditional polymers. Spanning a range of critical topics, this book begins with an introduction to biocarbon and polymer materials, providing a solid foundation. It then progresses into the latest research on biocarbon sources, processing techniques, and characterization methods. Subsequent chapters cover the mechanical, thermal, and electrical properties of biocarbon polymer composites, along with their applications in diverse industries such as automotive, construction, and packaging. Contributors highlight real-world case studies and examples to showcase the practical relevance of these materials. Readers will gain a comprehensive understanding of the science and technology behind biocarbon polymer composites, enabling them to make informed decisions in materials selection and development. In an era of increasing environmental consciousness, this book emphasizes the eco-friendly nature of biocarbon composites, offering sustainable alternatives to traditional plastics. Additionally, this book bridges the information gaps between different disciplines and it is intended for a wide range of readers, from materials scientists and engineers to environmentalists and industry policymakers.