Books published by Humana Press Inc.

Computer-Aided Tissue Engineering highlights the interdisciplinary nature of this topic and reviews the current state of computer-aided three-dimensional tissue modeling, tissue classification, and tissue fabrication and implantation.

Before the therapeutic potential of cell replacement therapy or the development of therapeutic drugs for stimulating the body's own regenerative ability to repair cells damaged by disease and injury can be fully realized, control of stem cell fate, immuno-rejection, and limited cell sources must be overcome.

Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists.

Clostridium difficile, a major nosocomial pathogen shown to be a primary cause of antibiotic-associated disease, has emerged as a highly transmissible and frequently antibiotic-resistant organism, causing a considerable burden on health care systems worldwide.

The Atlas of Robotic Urologic Surgery provides a detailed, step-by-step guide to common robotic urologic procedures for the purpose of helping novice surgeons in their transition to robotic surgery and seasoned robotic surgeons to refine their surgical technique and expand their repertoire of robotic procedures.

During the past decade as the data on gene sequences and expression patterns rapidly accumulated, cell-free protein synthesis technology has also experienced a revolution, becoming a powerful tool for the preparation of proteins for their functional and structural analysis.

Alzheimer's disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems that make us who we are.

Robotic technology has paved the way for new opportunities in pediatric urologic surgery. Written by highly respected surgeons, Pediatric Robotic Urology provides a state-of-the-art, comprehensive overview of the precise surgical techniques that are changing the practice of pediatric urologic surgery.

The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology.

This volume covers the scientific aspects of the entire portfolio of NIAID, including microbiology and infectious disease, HIV/AIDS, and immunology and vaccines. All major diseases and the relevant immunology and vaccine development are described in detail.

Over the past three decades, carotid artery stenting has evolved to become a promising and viable alternative to carotid endarterectomy, especially for patients deemed to have high surgical risks.

Whereas getting exact data about living systems and the sophistication of experimental procedures have primarily absorbed the minds of researchers previously, the weight increasingly shifts to the problem of interpreting accumulated data in terms of biological function and bio- lecular mechanisms.

Protein misfolding is a key feature of many disorders in humans, given that over twenty proteins are known to misfold and cause disease.

In RT-PCR Protocols, Second Edition, expert researchers fully update the technologies presented in the popular previous edition, such as competitive RT-PCR, nested RT-PCR, RT-PCR from single cells, and RT-PCR for cloning.

These include air and noise pollution control, solid waste processing and resource recovery, physicochemical treatment processes, biological treatment processes, biosolids management, water resources, natural control processes, radioactive waste disposal and thermal pollution control.

This book focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. It approaches research into the pathology and treatment of gynecologic oncology from both clinical and experimental perspectives. This new volume will be necessary reading for clinicians and experimental researchers alike.

Leading national and international urologists in the field of endourology describe standard and advanced endoscopic procedures for treating upper-tract pathology.

In the past decade there have been many research advances, such as directed differentiation of embryonic stem cells and induced pluripotent stem cells, robotic high throughput screening, whole genome siRNA and shRNA libraries, massively parallel sequencing at low cost, identification of somatic stem cells in key organs, to name a few.

The biological sciences are now in the midst of a true life sciences revolution akin to what physics experienced just after the turn of the last century. We are now in a phase of unparalleled growth that is reflected by the amount of data generated from each experiment. At the time of this writing, the rate of data acquisition was approaching 2 terabytes over the course of 5 days with first pass analysis proceeding over the following 2-3 week period. This fundamental shift has provided unprecedented opportunities that for the first time afford us the ability, i.e., means, breadth, and depth of data, to truly address human biology at the systems level. This wealth of information from seemingly disparate datasets and its integration is being realized through bioinformatics. It is with this philosophy that the text Bioinformatics for Systems Biology was born. This revolution has spawned true personalized medicine that encompasses diagnostics and treatment through to cure.For the physical and computer scientist, this text provides an introduction to the basic biological principles governing a cell. This quickly moves from the fundamentals to exploring the underlying genetic processes. While providing a rudimentary and necessary overview for the life scientist, the physical and computer scientist will be apprised of various nuances within the field reflecting the reality of "wet-bench" science. For those in the life sciences, it I rapidly becoming appreciated that we now progressing from examining our favorite "pet" gene to the system. Statistics is now an essential component to understand the vast datasets and this is emphasized throughout the text.The majority of the text is devoted to the common ground that these groups share. It provides rich examples of tools, databases, and strategies to mine the databases to reveal novel insights. A host of examples of parsing the data into a series of overlays that use various presentation systems are reviewed. The goal is to provide a representation most comfortable to the user to enable the user to thoroughly explore the data. The text concludes with examples of how the systems information is used to inform personalized medicine in a true "bench to bedside" manner.Bioinformatics for Systems Biology bridges and unifies many disciplines. It presents the life scientist, computational biologist, and mathematician with a common framework. Only by linking the groups together may the true life sciences revolution move forward in the mostly uncharted and emerging field of Systems Biology.

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type.

The generation of genetically modified mice is absolutely crucial to gene function studies today, primarily because mice are genetically similar to man and because gene function studies in mice are in the context of a whole organism, making them particularly useful.

This book provides an integrated collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine. It is the first book to comprehensively integrate molecular diagnostics and molecular pathology.