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This book applies modern molecular diagnostic techniques to the analysis of single cells, small numbers of cells, or cell extracts. Emphasis is placed on non-invasive analysis of single cell metabolites and the direct analysis of RNA and DNA from single cells, with a focus on polymerase chain reaction and fluorescence in situ hybridization.
Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.
Additional chapters describe cutting-edge noninvasive angiography and vascular flow studies, specific drug therapy for claudication, regression of atherosclerosis therapy, gene therapy, and drug eluting stents for peripheral arterial disease.
A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. Two appendices detail the genomic disorders, providing genomic features at the locus undergoing rearrangement, their clinical features, and frequency of detection.
Leading academic and industrial investigators surveys the world of microarray technology, describing in step-by-step detail diverse DNA and protein assays in clinical laboratories using state-of-the-art technologies.
A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science.
Leading world authorities drawn from cardiology, surgery, pediatrics, internal medicine, and basic science comprehensively survey the diagnostic, therapeutic, and prognostic aspects of cardiogenic shock.
In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas.
Allergy: Methods and Protocols aims to assist the researcher in gaining insight into the molecular mechanisms involved in allergy by featuring an array of protocols.
This collection of articles by leading orthopedic and craniofacial surgeons and researchers comprehensively reviews the biology of bone formation and repair, the basic science of autologous bone graft, allograft, bone substitutes, and growth factors, and explore their clinical application in patients with bone repair problems.
These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension.
In Handbook of Evidence Based Psychodynamic Psychotherapy: Bridging the Gap Between Science and Practice, the editors provide evidence that supports this type of research for two primary reasons.
Leading academic and biomedical researchers comprehensively review the status of essential fatty acids (EFA) in nutrition, medicine, psychology, and pharmacology.
Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings.
In Glutamate and Addiction, world-renowned scientific experts critically review all of the evidence for the role of glutamatergic systems in opiate, stimulant, and alcohol addiction.
There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery.
The police composite sketch, one of the most crucial investigative tools in law enforcement, is developed during a composite session-an intense display of communication and art in which the words of a witness are transformed into the features of a suspect.
In Characterization of Nanoparticles Intended for Drug Delivery, expert researchers explore the latest advances in the field, providing a set of basic methods for the characterization of nanomaterials for medical use.
In this book, Dr. Richard Allen Williams has assembled the very best scholars on healthcare disparities to raise the public consciousness of this issue.
This comprehensive book, intended for those providing medical care to children, provides an overview of pediatric pain. Each chapter provides an overview of the problem, followed by a "hands on" description of relevant assessment and intervention strategies.
The author provides today's most current information covering the four categories of prostatitis. An international group of contributors including urologists, scientists, psychologists, and pain specialists offer the reader new approaches to helping patients.
This book examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics.
Part III provides a series of tables providing organ weights and body measurements for fetuses, children and adults.Handbook of Autopsy Practice Fourth Edition is an essential resource for clinicians, pathologists, residents and students who strive to hone their trade and increase the value of the autopsies they perform.
Management options for patients with colorectal cancer have undergone d- matic changes over the past decade. Whereas at the start of 1996 only one drug, 5-Fluorouracil, was available for the treatment of this disease, a mere 10 yr later, six drugs are licensed for use in colorectal cancer, and others are in the late phases of clinical development.
A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS.
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