Books published by Humana Press Inc.

Collecting an extensive amount of information from thousands of publications by leading investigators in this rapidly developing field, this book provides a convenient and up-to-date one volume source for research in neural tumors of various cellular origins.

Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.

Vaccine research and development is advancing at an unprecedented pace, with an increasing emphasis on rational design based upon a fundamental und- standing of the underlying molecular mechanisms. The aim of this volume is to provide a selection of contemporary protocols that will be useful to both novice and advanced practitioner alike. The variety of procedures required to design, develop, produce, and assess a vaccine is immense and covers aspects of ch- istry, biochemistry, molecular biology, cell biology, and immunology. No single volume can hope to cover these topics exclusively. Rather, here we attempt to provide a methods sourcebook focusing on hands-on practical advice. Comp- mentary and background information may be found in other volumes in the Me- ods in Molecular Medicine series. Of particular interest are volumes on Dendritic Cell Protocols, Interleukin Protocols, Vaccine Adjuvants, and DNA Vaccines. Since the publication of the first edition of Vaccine Protocols there have been major advances, particularly in the areas of bacterial genomics, antig- specific T-cell quantification, genetic manipulation of vaccine vectors, the h- nessing of natural molecules concerned with the regulation of immune responses, and the burgeoning field of DNA vaccinology. Hence, the extensive revision of this edition with new chapters on live viral vaccine vectors, atte- ated bacterial vectors, immunomodulators, MHC-peptide tetrameric complexes, and the identification of vaccine candidates by genomic analysis. Additionally, chapters from the first edition have been updated to accommodate state-of-t- art methods in vaccinology.

Additional chapters examine the effects of gender bias in diagnosis and treatment, the role of gynecologists as primary care physicians for women, health technology assessment in an era of managed care, and the problems of analyzing cost-effectiveness in the diagnosis and treatment of coronary artery disease in women.

Prominent experts explain the pharmacology and metabolism of benzodiazepines (LDB) and g-hydroxybutyric acid (GHB) and offer powerful and effective methodologies that will enable better detection of these drugs in various body fluids, as well as in hair.

To meet varied needs, each Biomaterials Engineering and Devices: chapter provides clear ancd fully detailed Human Applications, focuses on materials discussions.

This complete laboratory reference manual explains the principles behind solid phase extraction (SPE) and provides readily reproducible protocols for solving extraction problems in forensic and clinical chemistry.

The distinguished contributors integrate a wide range of topics, including the basic biochemistry of EFAs and lipid metabolism, the role of EFAs in the neuronal membrane, the effects of EFAs and lipids in various diseases, and the effects of normal levels and EFA deficiencies on cognition and behavior.

In The Best Guide to Allergy, medical experts answer all your personal concerns and questions about allergy and asthma in easily understood language.

In Alcohol, Cocaine, and Accidents leading experts provide concise yet focused scientific reviews of the role of alcohol and cocaine in automotive, aviation, and aquatic accidents.

In ALLOCATING HEALTH CARE RESOURCES, leading authorities and researchers expose the basic philosophical, ethical, and economic issues underlying the current health care debate.

Endoscopic ultrasound has revolutionized the approach to lesions inside and outside the gastrointestinal tract.

The Physician Scientist's Career Guide provides a complete guide to having a successful career as a Physician Scientist.The Physician Scientist's Career Guide fulfills a unique and crucial need and will be an invaluable guide for medical students, fellows and newly appointed faculty members interested in a career in research.

One volume in a two-part series, covering the physiological and metabolic interactions between neurons and glia across the phylogenetic groups. New insights into neuron-glia relationships result from this comparative approach.

Topics of interest include the epidemiology of sudden death, management of ventilation, chest compression technique training, public access defibrillation, drug delivery during CPR, the latest drug therapies, and cardiac arrest in disease, pregnancy, drowning, lightning strike, and trauma.

In Chapter 1, Dokal and colleagues present simple protocols for the molecular investigation of Fanconi anemia and dyskeratosis congenita. In Chapter 3, Old details protocols for the molecular diagnosis of most forms of hemoglobinopathy.

Management of Pediatric Obesity and Diabetes provides healthcare trainees and professionals with practical, comprehensive, and contemporary approaches to the pediatric patient at risk for obesity, T2DM, and related conditions.

Complementing rather than replacing the classic textbooks in forensic pathology, the authors explore new avenues for analyzing the pathology of burned bodies, traumatic brain injury, death by drug abuse, sudden cardiac death, sudden infant death and neonaticide, and fatalities resulting from kicking and trampling.

Minimally invasive urologic surgery is revolutionizing how physicians treat many urologic diseases. Laparoscopic Urologic Oncology focuses on educating both general urologists and urologic oncologists on the current and future role of laparoscopy and other minimally invasive techniques in urologic oncology.

As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important.

Other areas of interest covered include suicide, viral myocarditis in sudden death cases, curious death scene phenomena (hiding, covering and undressing), forensic entomology, the interpretation of toxicological findings, anabolic-androgenic-steroid abuse, and autopsy findings of subendocardial hemorrhages.

Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

A collection of techniques for determining the factors governing microorganisms and their habitats. It presents, in detail, methods ranging from those for the study of marine organisms, to those for investigating microorganisms occurring in groundwater, to the biodiversity of yeasts found in remote environments.

This handbook describes many different types of biomarkers and their discovery. It also presents the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials.

Among the issues considered are whether stem cell research treats embryos as "commodities," violates the rights of human embryos, or alienates women from their reproductive labor, and whether human embryos are entitled to full membership in the moral community.