Books published by Mdpi AG

This special issue provides a collection of 15 papers with modern theories and applications for circular economy, engineering projects, entrepreneurship models, and investor decisions. After the commencing review on Occupational Health and Safety Management-Systems Standards, follow papers which can be classified into four categories which cover the overall scope of special issue. The first category includes papers regarding the micro-level of circular economy. This means case studies in firm-level which implement different techniques to achieve sustainable development and circular economy goals. The findings reveal interesting achievements which are associated with cultural characteristics of the countries these case studies have been conducted. The second category of papers refers to the meso-level of circular economy where firms cooperate with each other by exchanging byproducts and organizing common operational procedures and routines to address environmental problems. The findings suggest assessment information technology tools to support industrial symbiosis among European firms. The next body of literature encompasses macro-level where circular economy techniques are implemented at a country level. Findings suggest methodologies for implementing and tracking circular economy in cities. Finally, a number of papers are included that focus on advanced engineering techniques. These techniques are useful tools for achieving circular economy and sustainability.

Mycotoxins are toxic secondary metabolites produced by fungi. They cause deleterious effects on humans, animals, and plants. More than one hundred mycotoxins are known which contaminate food and feed raw materials. Fungal infection and mycotoxin contamination can occur directly in fields (pre-harvest stage), during storage, or during industrial processing (post-harvest stage). Given the proven toxicity of mycotoxins and their widespread distribution, it is necessary to prevent their occurrence in food and feed. To limit mycotoxin contamination, several techniques can be adopted at the pre-harvest or post-harvest stages. These techniques can reduce mycotoxin concentration through fungal growth reduction or mechanisms leading to mycotoxin degradation or mycotoxin detoxification (i.e., reduction of the toxicity). Until very recently, fungicides were favored to limit mycotoxin contamination by reducing fungal growth. Nonetheless, the sanitary and environmental impacts of these products and their effects on food quality encourage the development of alternative strategies based on biocontrol agents (BCAs) or natural compounds. Moreover, in some cases, fungal growth reduction can stimulate mycotoxin production. The focus of this Special Issue of Toxins is to gather the most recent advances related to reducing mycotoxin contamination in food and feed using BCAs and natural compounds. In this context, two main types of approaches can be proposed: Preventive methods that could be applied in the field, during storage, or during industrial processing and curative methods that detoxify contaminated matrices by eliminating the produced mycotoxin.

The article entitled "Selected Aspects of Evaluating Knowledge Management Quality in Contemporary Enterprises" broadens the understanding of knowledge management and estimates select aspects of knowledge management quality evaluations in modern enterprises from theoretical and practical perspectives. The seventh article aims to present the results of pilot studies on the four largest Information Communication Technology (ICT) companies'' involvement in promoting the Sustainable Development Goals (SDGs) through social media. Studies examine which communication strategy is used by companies in social media. The primary purpose of the eighth article is to present the relationship between trust and knowledge sharing, taking into account the importance of this issue in the efficiency of doing business. The results showed that trust is vital in sharing knowledge and essential in achieving a high-performance efficiency level. The ninth article presents the impact of social media on consumer choices in tourism and tourist products'' specificity. The study''s main purpose was to indicate the most commonly used social media in selecting a tourist destination and implementing Generation Y''s journey. The 10th article aims to identify the most critical purposes of using social media by responding to women''s attitudes according to age and their respective countries'' economic development. The research was done through an online survey in 2017-2018, followed by an analysis of eight countries'' results. The article entitled "Integrated Question-Answering System for Natural Disaster Domains Based on Social Media Messages Posted at the Time of Disaster" presents the framework of a question-answering system that was developed using a Twitter dataset containing more than 9 million tweets compiled during the Osaka North Earthquake that occurred on 18 June 2018. The authors also study the structure of the questions posed and develop methods for classifying them into particular categories to find answers from the dataset using an ontology, word similarity, keyword frequency, and natural language processing. The book provides a theoretical and practical background related to trust, knowledge management, and communication in the era of social media. The editor believes that the collection of articles can be relevant to professionals, researchers, and students'' needs. The authors try to diagnose the situation and show the new challenges and future directions in this area.

Sustainability is a fairly old concept, born in the 18th century in the field of forestry, within a mono-functionality perspective. The concept has considerably evolved in the last few years towards a multi-functionality context, with applications reported in practically all areas of economic interest. On the other hand, modern sustainability is a complex problem, for two reasons: a) The multiplicity of functions of a very different nature involved in the process and b) The manner in which different segments of the society or stakeholders perceive the relative importance of these functions. For the above reasons, a realistic approach for dealing with the sustainability issue requires taking into consideration multiple criteria of different nature (economic, environmental and social), and in many cases within a participatory decision making framework. This book presents a collection of papers, dealing with different theoretical and applied issues of sustainability, with the help of a modern multi-criteria decision-making theory, with a single as well as several stakeholders involved in the decision-making process. Hopefully, this material will encourage academics and practitioners to alter their research in this hot and vital topic. After all, the sustainable management of the environment and its embedded resources is one of the most important, if not the major challenge of the 21st century.

The early days of tourism development had a naïve vision of tourism''s impacts on society in terms of economic, social, and environmental benefits. Time has passed, and we have learnt lessons regarding the success and failure of tourism development. Mass tourism development has pros and cons and is not necessarily the optimal development model. Alternative development strategies should be contemplated. This Special Issue deals with different topics concerning optimal tourism development. Destination management requires further understanding of different issues, such as carrying capacity, income-based optimal supply size, identification and development of optimal market niches, and adaptation or environmental protection strategies. Tourism planning is concerned with the role of economies of agglomeration, i.e., the advantages of spatial clusters vs scattered development. Additionally, support for and investment in innovation, accessibility, and mobility are relevant nowadays. From the stakeholders'' perspective, it is relevant to discuss ways of cooperating and sources of conflicts among different sectors and actors, governance and incentives for sustainable tourism practices, and equity and economic distribution of benefits. Finally, the development of methodological tools for the assessment of optimal tourism development is necessary for policy making, in particular the development of methods that are capable of integrating economic, environmental, and social criteria.

Thank you for reaching for this book. It is a summary of the research presented at the 6th International Conference on Renewable Energy Sources (ICORES19), which took place in Krynica, Poland, in June 2019. This event is the most recognizable scientific meeting connected to RES in Poland. From the very beginning, this conference has been a unique occasion for gathering Polish and international researchers'' perspectives on renewable energy sources and balancing them against governmental policy considerations. Accordingly, the conference has also offered panels to discuss best practices and solutions with local entrepreneurs and federal government bodies. The meeting attracts not only scientists but also industry representatives, as well as local and federal government personnel. We are open to new and fresh ideas concerning renewable energy, which is why so many scientists from Central and Eastern Europe visit Krynica to discuss the "Green Future" of this region. In 2019, the conference was organized by the University of Agriculture in Krakow, in cooperation with the AGH University of Science and Technology (Krakow), the State Agrarian and Engineering University in Podilya, the University of ┼╜ilina, the International Commission of Agricultural and Biosystems Engineering (CIGR) and the Polish Society of Agricultural Engineering. Honorary auspices were made by the Ministry of Science and Higher Education of the Republic of Poland, the rector of the University of Agriculture in Krakow, the rector of the AGH University of Science and Technology and the rector of the State Agrarian and Engineering University in Podilya.

The Special Issue of Separations, "Development of Alternative Green Sample Preparation Techniques", provides an overview on recent trends in green sample preparation. This Special Issue of Separations collates 11 impressive contributions that describe the state-of-the-art in the development of green extraction technologies, from green materials for microextraction to the development of new sampling devices geometries for enhanced extraction efficiency and analysis throughput.

This highly informative and carefully presented book covers the most recent advances as well as comprehensive reviews addressing novel and state-of-the-art topics from active researchers in innovative advanced materials and hybrid materials, concerning not only their synthesis, preparation, and characterization but especially focusing on the applications of such materials with outstanding performance.

This book presents the results of the successful Sensors Special Issue on Intelligent Vehicles that received submissions between March 2019 and May 2020. The Guest Editors of this Special Issue are Dr. David Fernández-Llorca, Dr. Ignacio Parra-Alonso, Dr. Iván García-Daza and Dr. Noelia Parra-Alonso, all from the Computer Engineering Department at the University of Alcalá (Madrid, Spain). A total of 32 manuscripts were finally accepted between 2019 and 2020, presented by top researchers from all over the world. The reader will find a well-representative set of current research and developments related to sensors and sensing for intelligent vehicles. The topics of the published manuscripts can be grouped into seven main categories: (1) assistance systems and automatic vehicle operation, (2) vehicle positioning and localization, (3) fault diagnosis and fail-x systems, (4) perception and scene understanding, (5) smart regenerative braking systems for electric vehicles, (6) driver behavior modeling and (7) intelligent sensing. We, the Guest Editors, hope that the readers will find this book to contain interesting papers for their research, papers that they will enjoy reading as much as we have enjoyed organizing this Special Issue

The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic "state" of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on "New aspects of cancer stem cell biology: implications for innovative therapies" aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies.

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly the two families of claudins and TAMPs-several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.

The food processing industries produce millions of tons of losses and waste during processing, which are becoming a grave economic, environmental, and nutritional problem. Fruit, vegetable, and food industrial solid waste include leaves, peels, pomace, skins, rinds pulp, stems, seeds, twigs, and spoiled fruits and vegetables, among other waste released in food production, which can be formed during cleaning, processing, cooking, and/or packaging. These wastes are characterized by being an important source of bioactive compounds, such as phenolic compounds, dietary fibers, polysaccharides, vitamins, carotenoids, pigments, and oils, among others. These bioactive compounds are closely associated with beneficial effects on human health. These by-products can be exploited in different industries: in food industries for the development of functional ingredients and/or new foods or natural additives; in pharmaceutical industries for medicinal, healthcare, or cosmetic products; in agricultural industries as fertilizers or animal feed; and in chemical industries, among others. The reutilization of these by-products will ensure the sustainable development of food industries and reduce their environmental impact, which will contribute to the fight against environmental problems, leading to potential mitigation of climatic change. Therefore, the determination of bioactive compound composition in agricultural and food waste and the production of extracts containing these compounds is the first step towards its reutilization.

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and still represents one of the global health threats to mankind. The World Health Organization estimated more than 10 million new cases and reported more than 1.5 million deaths in 2019, thus ranking TB among the main causes of death due to a single pathogen. Standard anti-TB therapy includes four first-line antibiotics that should be administered for at least six months. However, in the case of multi- and extensively drug-resistant TB, second-line medications must be used and these frequently cause severe side effects resulting in poor compliance. Developing new anti-TB drug candidates is therefore of outmost importance. In this Special Issue dedicated to Tuberculosis Drug Discovery and Development, we present the main and latest achievements in the fields of drug and target discovery, host-directed therapy, anti-virulence drugs, and describe the development of two advanced compounds: macozinone and delpazolid. In addition, this Special Issue provides an historical perspective focused on Carlo Forlanini, the inventor of pneumothorax for TB treatment, and includes an overview of the state-of-the-art technologies which are being exploited nowadays in TB drug development. Finally, a summary of TB vaccines that are either approved or undergoing clinical trials concludes the Special Issue.

The convergence of big data and geospatial computing has brought forth challenges and opportunities to Geographic Information Science with regard to geospatial data management, processing, analysis, modeling, and visualization. This book highlights recent advancements in integrating new computing approaches, spatial methods, and data management strategies to tackle geospatial big data challenges and meanwhile demonstrates opportunities for using big data for geospatial applications. Crucial to the advancements highlighted in this book is the integration of computational thinking and spatial thinking and the transformation of abstract ideas and models to concrete data structures and algorithms.

Unmanned aerial vehicles (UAVs) are new platforms that have been increasingly used in the last few years for forestry applications that benefit from the added value of flexibility, low cost, reliability, autonomy, and capability of timely provision of high-resolution data. The main adopted image-based technologies are RGB, multispectral, and thermal infrared. LiDAR sensors are becoming commonly used to improve the estimation of relevant plant traits. In comparison with other permanent ecosystems, forests are particularly affected by climatic changes due to the longevity of the trees, and the primary objective is the conservation and protection of forests. Nevertheless, forestry and agriculture involve the cultivation of renewable raw materials, with the difference that forestry is less tied to economic aspects and this is reflected by the delay in using new monitoring technologies. The main forestry applications are aimed toward inventory of resources, map diseases, species classification, fire monitoring, and spatial gap estimation. This Special Issue focuses on new technologies (UAV and sensors) and innovative data elaboration methodologies (object recognition and machine vision) for applications in forestry.

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ-mainly the two families of claudins and TAMPs-several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.

Coatings here provides a selection of 10 papers, published in 2019, from researchers and institutions based in various countries around the world (nine European, one American, and one Asian), allowing us to appreciate the variety and significance of ongoing research in the wide field of protective and functional coatings.

This book presents a sample of theoretical and practical advances in applied sciences in the study of technical historical and/or industrial heritage. It covers several applications, such as geometric modelling and virtual reconstruction, computer-aided design and kinematic simulation, history of manufacturing, digital techniques in industrial heritage areas, building efficient management models, proposal for heritage intervention in a BIM environment, three-dimensional modelling using unmanned aerial vehicle imagery, computer-aided design, computer-aided engineering, and multi-criteria cataloging of the immovable items of industrial heritage. The contributions included in this book describe the state-of-the-art advances in this field and indicate the potential of studies of technical historical or industrial heritage in multidisciplinary applications in the fields of engineering and architecture.

This Special Issue focuses on the state-of-the-art results from the definition and design of filters for low- and high-frequency applications and systems. Different technologies and solutions are commonly adopted for filter definition, from electrical to electromechanical and mechanical solutions, from passive to active devices, and from hybrid to integrated designs. Aspects related to both theoretical and experimental research in filter design, CAD modeling and novel technologies and applications, as well as filter fabrication, characterization and testing, are covered. The proposed research articles deal with different topics as follows: Modeling, design and simulation of filters; Processes and fabrication technologies for filters; Automated characterization and test of filters; Voltage and current mode filters; Integrated and discrete filters; Passive and active filters; Variable filters, characterization and tunability.

Modern technology has eliminated barriers posed by geographic distances between people around the globe, making the world more interdependent. However, in spite of global collaboration within research domains, fragmentation among research fields persists and even escalates. Disintegrated knowledge has become subservient to the competition in the technological and economic race, leading in the direction chosen not by reason and intellect but rather by the preferences of politics and markets. To restore the authority of knowledge in guiding humanity, we have to reconnect its scattered isolated parts and offer an evolving and diverse but shared vision of objective reality connecting the sciences and other knowledge domains and informed by and in communication with ethical and esthetic thinking and being. This collection of articles responds to the second call from the journal Philosophies to build a new, networked world of knowledge with domain specialists from different disciplines interacting and connecting with the rest of the knowledge-producing and knowledge-consuming communities in an inclusive, extended natural-philosophic, human-centric manner. In this process of reconnection, scientific and philosophical investigations enrich each other, with sciences informing philosophies about the best current knowledge of the world, both natural and human-made, while philosophies scrutinize the ontological, epistemological, and methodological foundations of sciences.

Materials of extreme wetting properties have received significant attention, as they offer new perspectives providing numerous potential applications. Water- and oil-repellent surfaces can be used, for instance, in the automobile, microelectronics, textile and biomedical industries; in the protection and preservation of constructions, buildings and cultural heritage; and in several other applications relevant to self-cleaning, biocide treatments, oil-water separation and anti-corrosion, just to name a few. The papers included in this book present innovative production methods of advanced materials with extreme wetting properties that are designed to serve some of the abovementioned applications. Moreover, the papers explore the scientific principles behind these advanced materials and discuss their applications to different areas of coating technology.

Periodontitis is an infection-induced inflammatory disease accounting for huge healthcare costs and socio-economic impacts. Bacteria from the indigenous oral flora colonize the interspace between the tooth and the connective tissue, which induces an inflammatory response. If the bacteria proliferate and release virulence factors, they cause an imbalance in the host inflammatory response that induces degenerative processes in the surrounding tissues. This process is often slow, and the disease affects mainly older people, but the process could be rapid and affect young individuals if certain pathogens colonize the area. The two most studied periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans, express virulence factors, including proteases and exotoxins. Periodontal bacteria and their products can be translocated to the peripheral circulation and are therefore linked to the risk pattern of several systemic diseases. However, it is not known if the increased risk for systemic disease associated with periodontitis is an effect of the invading bacteria and/or their released products, the release of components from the local inflammatory response, or a common host susceptibility pattern. The most studied periodontitis-associated systemic diseases are cardiovascular diseases and rheumatoid arthritis. Here, we want to shed light on mechanisms behind the associations of periodontal infections with systemic inflammation.

This book presents a compendium of the 10 articles published in the recent Special Issue "Distance and Domination in Graphs". The works appearing herein deal with several topics on graph theory that relate to the metric and dominating properties of graphs. The topics of the gathered publications deal with some new open lines of investigations that cover not only graphs, but also digraphs. Different variations in dominating sets or resolving sets are appearing, and a review on some networks'' curvatures is also present.

Nerve sheath tumors can be a significant cause of morbidity for many patients. These include benign tumors such as schwannomas, diffuse and plexiform neurofibromas, and atypical neurofibromas, as well as the aggressive soft tissue sarcoma known as the malignant peripheral nerve sheath tumor (MPNST). Nerve sheath tumors occur sporadically and in the context of the clinical neuro-genetic tumor predisposition syndromes neurofibromatosis type 1 (NF1) and type 2 (NF2). Historically, the mainstay of treatment for nerve sheath tumors has been surgery. However, for both benign and malignant nerve sheath tumors, there is a high recurrence rate, highlighting the pressing need for novel therapies. As we have entered the genomic era, the hope is that an improved understanding of the genetics, and therefore the biology, of these tumors will ultimately lead to therapies that result in better outcomes. In this Special Issue, we include both review articles and original research related to the genomic understanding and modeling of schwannomas, plexiform and diffuse neurofibromas, atypical neurofibromas, and malignant peripheral nerve sheath tumors as well as genomic methods being developed and applied to advance our understanding of these tumors.

TB is considered as one of the oldest documented infectious diseases in the world and is believed to be the leading cause of mortality due to a single infectious agent. Mtb, the causative agent responsible for TB, continues to afflict millions of people worldwide. Furthermore, one-third of the entire world''s population has latent TB. Consequently, there has been a worldwide effort to eradicate and limit the spread of Mtb through the use of antibiotics. However, management of TB is becoming more challenging with the emergence of drug-resistant and multi-drug resistant strains of Mtb. Furthermore, when administered, many of the anti-TB drugs commonly present severe complications and side effects. Novel approaches to enhance the host immune responses to completely eradicate Mtb infection are urgently needed. This Special Issue will therefore cover most recent advances in the area of host-directed therapies for TB.

This collection of 11 papers introduces broad topics covering various professional disciplines related to the research arena of land use and water quality. The papers exemplify the important links between agriculture and water quality in surface and ground waters as well as the pollution problems around urban areas. Advancement of new technologies for analyzing links between land use and water quality problems as well as insights into new tools for analyzing large monitoring datasets are highlighted in this collection of papers.

This Nutrients Special Issue focuses on neonatal nutritional advances for inflammatory disorders affecting infants such as necrotizing enterocolitis (NEC). Nutrition can significantly impact the development of certain diseases that afflict infants. This Special Issue aims to bring together the latest research on the role of nutrition in preventing or impacting neonatal disorders. Specifically, this Special Issue focuses on the role of breast milk or donor breast milk and the various components in milk that have been demonstrated to protect against NEC and other inflammatory diseases. This issue provides a comprehensive composite of the advances in nutritional strategies that can modulate or prevent neonatal intestinal disorders.

Pharmaceuticals, due to their pseudo-persistence and biological activity as well as their extensive use in human and veterinary medicine, are a class of environmental contaminants that is of emerging concern. In contrast to some conventional pollutants, they are continuously delivered at low levels, which might give rise to toxicity even without high persistence rates. These chemicals are designed to have a specific physiological mode of action and to resist frequently inactivation before exerting their intended therapeutic effect. These features, among others, result in the bioaccumulation of pharmaceuticals which are responsible for toxic effects in aquatic and terrestrial ecosystems. It is extremely important to know how to remove them from the environment and/or how to implement procedures or treatments resulting in their biological inactivation. Although great advances have been made in their detection in aquatic matrices, there remains limited analytical methodologies available for the trace analysis of target and non-target pharmaceuticals in matrices such as soils, sediments, or biota. There are still many gaps in the data on their fate and behavior in the environment as well as on their threats to ecological and human health. This book has included nine current research and three review articles in this field.

The Industrial Internet of Things (Industrial IoT-IIoT) has emerged as the core construct behind the various cyber-physical systems constituting a principal dimension of the fourth Industrial Revolution. While initially born as the concept behind specific industrial applications of generic IoT technologies, for the optimization of operational efficiency in automation and control, it quickly enabled the achievement of the total convergence of Operational (OT) and Information Technologies (IT). The IIoT has now surpassed the traditional borders of automation and control functions in the process and manufacturing industry, shifting towards a wider domain of functions and industries, embraced under the dominant global initiatives and architectural frameworks of Industry 4.0 (or Industrie 4.0) in Germany, Industrial Internet in the US, Society 5.0 in Japan, and Made-in-China 2025 in China. As real-time embedded systems are quickly achieving ubiquity in everyday life and in industrial environments, and many processes already depend on real-time cyber-physical systems and embedded sensors, the integration of IoT with cognitive computing and real-time data exchange is essential for real-time analytics and realization of digital twins in smart environments and services under the various frameworks'' provisions. In this context, real-time sensor networks and systems for the Industrial IoT encompass multiple technologies and raise significant design, optimization, integration and exploitation challenges. The ten articles in this Special Issue describe advances in real-time sensor networks and systems that are significant enablers of the Industrial IoT paradigm. In the relevant landscape, the domain of wireless networking technologies is centrally positioned, as expected.