Books published by Morgan & Claypool Publishers

Working with the National Institute of Mental Health (NIMH), the Rutgers Cell and DNA Repository (RUCDR) has begun banking iPSC source cells and converting those source cells into iPSC for distribution to the scientific community. This book provides detailed protocols for reprogramming either fibroblasts with retroviral vectors or cryopreserved lymphocytes with Sendai viral vectors.

Provides a simple approach to understand the essential elements of the angiogenic process, critiques the most powerful angiogenesis assays that are used to discover proangiogenic and antiangiogenic substances, and provides an in-depth physiological perspective on how angiogenesis is regulated in normal, healthy tissues of the human body.

Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly.

Summarizes our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behaviour, and the pathophysiology of edema formation.

Different regulatory networks are activated in different posterior neural regions, and these networks induce specific neural cell types in each region. Elucidating how each of these networks specify different cell fates is crucial for understanding the basic tenets of how Wnt morphogenetic activity induces the posterior nervous system during the earliest stages of vertebrate development.

The function of the cardiovascular system is strongly affected by the operation of the renal sodium excretion-body fluid volume-arterial pressure negative feedback system that maintains arterial blood pressure at a controlled value over long periods. This volume integrates the basic knowledge of these cardiovascular system components into an understanding of cardiac output regulation.

Reviews the current status of our knowledge of fluid transport across the intestine, including the complexities of transcellular and paracellular ion transport down the length of the intestine and how aberrations of normal physiological processes lead to disease.

Proprotein convertases (PCs) are a family of proteases including PC1, PC2, Furin, PC4, PACE4, PC5, and PC7. This title discusses a number of previous and recent findings on the PCs features, their implication in the regulation of multiple cellular functions that impact on the invasive/metastatic potential of cancer cells, and their clinical relevance in cancer patients.

X-linked adrenoleukodystrophy (X-ALD) is the most common leukodystrophy and the most frequent peroxisomal disorder, with an estimated incidence of 1:17,000. This complex neurodegenerative disorder is characterized by a huge clinical variability both in the age of onset and in symptoms.

Epilepsy affects approximately 3% of the population, and is usually defined as a tendency to experience recurrent seizures arising from periodic neuronal hyperexcitability of unknown causes. Different genetic factors, through various mechanisms, can cause this abnormal neuronal behaviour. The etiology of epilepsy is a major determinant of clinical course and prognosis.

Describes the unique anatomy and physiology of the vascular beds that serve the eye. The need for an unobstructed light path from the cornea to the retina and a relatively fixed corneal curvature and distance between refractive structures pose significant challenges for the vasculature to provide nutrients and remove metabolic waste.

Applying for and obtaining a patent is a process that can be unpredictable and intimidating, although it does not necessarily need to be. Novice and experienced inventors often have questions regarding patenting and the patenting process. This book answers many questions regarding the patenting process. It also describes the technologies typically patented in connection with regenerative medicine.

Discusses properties and interactions of membrane molecules that lead to nanodomain formation, new and emerging technologies by which nanodomains can be studied, and experimental examples that illustrate both highlights and current limitations of our present knowledge of the properties of membrane nanodomains in various cell types.

I had the good fortune to work at the National Cancer Institute from 1965 to 2005. The National Cancer Institute provided an environment that permitted my curiosity to flourish. The work described in this manuscript was performed during a period of rapid advances in genetics. I was able to apply my clinical training and new genetic tools to study human kidney cancer.

This book is intended to be a course about the creation and evolution of the universe at large, including the basic macroscopic building blocks (galaxies) and the overall large-scale structure.This text covers a broad range of topics for a graduate-level class in a physics department where students' available credit hours for astrophysics classes are limited. The sections cover galactic structure, external galaxies, galaxy clustering, active galaxies, general relativity and cosmology.

This book introduces the reader into the field of the physics of processes occurring in porous media. It targets Master and PhD students who need to gain fundamental understanding the impact of confinement on transport and phase change processes. The book gives brief overviews of topics like thermodynamics, capillarity and fluid mechanics in order to launch the reader smoothly into the realm of porous media. In-depth discussions are given of phase change phenomena in porous media, single phase flow, unsaturated flow and multiphase flow. In order to make the topics concrete the book contains numerous example calculations. Further, as much experimental data as possible is plugged in to give the reader the ability to quantify phenomena.

Nitric oxide (NO) is a key regulator of various cellular signaling pathways throughout the body and plays an important role in renal function under normal physiological and pathophysiological conditions. The goal of this book is to highlight the actions of NO within the kidney and its effects on the regulation of renal blood flow and tubular transport.

This review draws attention to the potential diagnostic and therapeutic implications of genomic and transcriptional profiling in heart failure and translational genomics research that is likely to permit greater personalization of prevention and treatment strategies to address the complexities of managing clinical heart failure.

Stem cells have great potential in regenerative medicine and tissue injury. Regulation of stem cell homeostasis in a 3D microenvironment is controlled by the niche components that influence stem cell fate, regulation, and function. It is therefore necessary to understand the mechanisms of cell-cell interaction, molecular cross talk between stem cells and their extracellular matrix environment.

Recent genome-wide association studies have identified various loci and genes that confer susceptibility to ischemic stroke or intracranial aneurysm. Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage.

Addresses the evidence for endocrine disrupting chemical (EDC) action on the developing brain. Topics covered include background about EDCs, evidence for exposures, concerns about EDC effects in the developing organism, and particularly on the developing nervous system, how EDCs perturb the brain's neuroendocrine systems, and transgenerational epigenetic effects of EDCs.