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In 1970 American neurosurgeon Robert White and his team carried out the first full head transplant in living monkeys. However, the resulting chimera was left tetraplegic and died a few days later. Fifty years on, the technology to perform a human cephalosomatic anastomosis is finally available. In this groundbreaking book, the pioneers of this new medical frontier bring together an international team of scientists to reveal for the first time the entire body of animal and human research and experimentation that made this breakthrough possible. Readers -- professionals, journalists, educated laypersons- will get unadulterated access to the published and unpublished body of evidence that has shocked the world since 2013. Only a deep appreciation of this technology can inform the ethical debate that has raged since 2013. Above all, the possibility of extending life raises profound dilemmas. This book brings clarity to the current debate and provides the instruments to make an informed decision on the most sensitive of subjects: overcoming death.
The Small Business Administration (SBA) administers several types of programs to support small businesses, including loan guaranty and venture capital programs to enhance small business access to capital; contracting programs to increase small business opportunities in federal contracting; direct loan programs for businesses, homeowners, and renters to assist their recovery from natural disasters; and small business management and technical assistance training programs to assist business formation and expansion. This has grown especially acute in recent months due to the widespread, adverse impact of the novel coronavirus (COVID-19) pandemic on the national economy. This book looks at some of the issues small businesses may face during the pandemic.
Volume 65 opens with an experimental study examining whether the language mindset of English as a Foreign Language pre-service teachers significantly relates to their task-oriented state-anxiety, changes in epigenetic activity, and task performance on a translation task. Following this, the authors review published research studies focusing on the use of Facebook, Instagram, and Twitter by students and teachers in higher education. This compilation also examines intellectual maturity, taking into account the specific features of interaction between teaching staff and learners in conditions of anthropological crisis. The authors analyse the new research models in education sciences born from the emergence of information and communication technologies, with the objective of determining the structures presenting in the last decade. The phenomenon of Massive Open Online Course courses is described, seeking to objectively determine what their advantages and disadvantages are, as well as how to improve their implementation. The concluding chapter reports on the results of a pilot study introducing a chatbot to assist with the development of learning communities at a small, largely international London university.
The role of CYP2D6 in the pharmacokinetic and/or pharmacodynamic differences in opiates and opioid consumers is discussed, as well as the associated genetic implications and consequences in the scope of clinical and forensic toxicology. Studies conducted on postmortem pharmacogenetic cases are investigated, and the benefits of CYP2D6 profiling during forensic investigations are discussed. The authors discuss recent advances in the split crest technique, underlining the importance of soft tissue management, especially at the level of the upper jaw where bone augmentation may be sufficient to install dental implants, but soft tissue grafting is necessary to achieve adequate aesthetic results. Hyaluronan or hyaluronic acid, an extracellular polysaccharide usually found associated with the cell surfaces, is explored. The subsequent article deals with the various stages, pathology, etiology and recent treatments associated with rheumatoid arthritis. Additionally, a comparative survey of current cardiovascular imaging practices/methodologies is provided, including magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT), and ultrasonography. The closing study highlights the fundamentals of pharmaceutical gels, their morphological and rheological properties, formulation considerations, and analytical and stability aspects.
Metabolic disorder caused by altered levels of metabolism resulting pathophysiological abnormalities often leads to childhood death. Several new developments on metabolic diseases research have been emerging. Gaucher disease is a lysosomal storage disorder caused by glucocerebrosidase gene mutations resulting glucocerebrosidase deficiency. Current studies show that the same gene mutations also contribute to the Parkinson''s disease. Tetrahydrobiopterin (BH4) has been widely used in treating patients with Phenylketonuria over a decade. Recent studies reveal that patients treated with BH4 over one-year period showed reduced levels of serum B12, folate and iron intake and therefore patients under chronic BH4 treatment needed to be advised to have additional micronutrients along with BH4. Macrocephaly was used as one of the important features to diagnose Canavan disease. However, a recent study showing a child with aspartoacylase gene mutation developed microcephaly. Hence, Canavan disease phenotype can be either macrocephaly or microcephaly. These are a few examples of recent developments on metabolic diseases research. Therefore, this book was aimed to compose current developments on metabolic diseases research for the use by broad spectrum of experts including Physicians, Neuroscientists, Neurologists, Biomedical researchers, Biochemists, Molecular biologists, Basic Science Researchers and Medical Students.
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