Books published by Springer Nature Singapore

The aim of this book is to introduce the clinical applications of various flaps in oncoplastic surgery. After a brief introduction of the background and anatomical basis of breast reconstruction, the book shows surgical reconstruction procedures using different types of flaps, for example, deep inferior epigastric perforator (DIEP) flap, profunda artery perforator flap and omentum flap. The great number of representative clinical cases together with high quality operative pictures constitute one of the highlights of this book. These pictures provided with details in flap design, elevation, harvest, transfer, and complications management. Furthermore, the use of Indocyanine green angiography and three-dimensional shaping with autologous tissue transplantation is discussed. Written by a group of experienced oncoplastic surgeons, this book offers a valuable reference work for medical researchers and practitioners in microsurgery, plastic and reconstructive surgery.

This book aims to present the latest research on drug delivery systems. It summarizes emerging drug delivery strategies and new technologies for cancer treatment, viewed through the lens of cancer pathology. Topics include immunotherapy strategies, biomimetic drug delivery strategies, live cell drug delivery strategies, nanocrystal technology, and 3D printing technology. The book is intended for researchers, R&D engineers, and graduate students in the pharmaceutical field. Additionally, it is expected to inspire collaboration among experts from different disciplines to advance the development of drug delivery systems.

This book constitutes the refereed proceedings of the 5th China Conference on Intelligent Networked Things, CINT 2022, held in Urumqi, China, during August 7-8, 2022. The 45 full papers included in this book were carefully reviewed and selected from 130 submissions. They were organized in topical sections as follows: Access, Perception, and Prediction in Intelligent Networked Things, Control of Intelligent Networked Things and Modeling, Simulation and Optimization of Intelligent Networked Things.

This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.¿

This book mainly introduces the research overview, research results, and follow-up prospects of ¿Key Basic Scientific Problems on Near-Space Vehicles¿, a major research plan of National Natural Science Foundation of China (hereinafter referred to as the Plan). The Plan is the first systematic basic hypersonic research program in China. From its inception in 2007 to its successful completion in 2016, the Plan lasted nine years, funded a total of 173 projects, and the funding totaled 190 million yuan. From the perspective of major national needs and scientific discipline development, the book focuses on four key scientific issues: aerodynamics in a near-space flight environment; advanced propulsion theories and methods; ultralight materials/structures, thermal environment prediction and thermal protection; and intelligent autonomous control theories and methods for hypersonic vehicles. The book also demonstrates Chinäs systematic and innovative achievements in interdisciplinarytheories and methods and innovative techniques, paving the way for a distinctively Chinese basic research framework and further breakthroughs of near-space hypersonic vehicles.

This book focuses on Chinese cases on the CISG decided by Chinese courts of all levels, mainly from 2006 to 2010. During this period, the number of cases grew gradually. The total number of cases still remained low, the reasons of which might be the following: parties were not familiar with the CISG and therefore decided to opt out of it; in addition, the case collection and report systems in China at that time were not as developed as now, rendering many cases inaccessible.This book provides a comprehensive and detailed analysis of selected cases. The analysis of those cases will be on a case by case basis. For each case, an English summary of the judgments will be provided. In the summary, the People¿s Court¿s approach to the interpretation and application of the CISG will be emphasised. Following the summary are comments of the individual case written either by an academic or a current or former judge from international and comparative perspective to discuss the successes and pitfalls of the interpretation and application of the CISG.This book deals with the cases from 2006 to 2010 in China. These cases reflect how People¿s Court of all levels started to deal with various issues arising from the CISG and will help understand whether and how the People¿s Courts change their approaches to the interpretation and application of the CISG in future.

This is the third in a series of three volumes of proceedings of the 23rd Pacific Basin Nuclear Conference (PBNC 2022) which was held by Chinese Nuclear Society. As one in the most important and influential conference series of nuclear science and technology, the 23rd PBNC was held in Beijing and Chengdu, China in 2022 with the theme ¿Nuclear Innovation for Zero-carbon Future¿. For taking solid steps toward the goals of achieving peak carbon emissions and carbon neutrality, future-oriented nuclear energy should be developed in an innovative way for meeting global energy demands and coordinating the deployment mechanism. It brought together outstanding nuclear scientists and technical experts, senior industry executives, senior government officials and international energy organization leaders from all across the world. The proceedings highlight the latest scientific, technological and industrial advances in Nuclear Safety and Security, Operations and Maintenance, New Builds, Waste Management, Spent Fuel, Decommissioning, Supply Capability and Quality Management, Fuel Cycles, Digital Reactor and New Technology, Innovative Reactors and New Applications, Irradiation Effects, Public Acceptance and Education, Economics, Medical and Biological Applications, and also the student program that intends to raise students¿ awareness in fully engaging in this career and keep them updated on the current situation and future trends. These proceedings are not only a good summary of the new developments nuclear science and technology, but also a useful guideline for the researchers, engineers and graduate students.

In the context of global population aging , the aging population of China is not only a China-specific problem but also a global concern. Based on in-depth analysis, this book focuses on the increasingly serious issue of aging population of China at the present time, and explores the possible path and solution from the new type of demographic dividend that is innovation. With 1/5 of the global aging population in the world, China has the largest aging population and is aging faster and deeper, which produces and , profound and far-reaching impact on the economic growth, social security, health care and other related areas.

This book on biogas is about the production and use of biogas with an emphasis on the raw materials and processes suitable for use in Southeast Asia. It is a gas formed when organic matter decomposes in an anaerobic digestion process. It can be made from any organic substance but the most economic are organic products from waste such as agricultural or general household waste, sewage, manure, municipal waste or food waste. As this raw material can be renewed indefinitely, biogas produced from it, is considered a renewable energy source. Worldwide interest in renewable energy sources is gathering momentum especially as concern for climate change mounts. Biogas generation helps reduce reliance on the use of fossil fuels. Producing biogas through biodigestion is non-polluting as there is no combustion or energy addition especially in the warmer climes of Southeast Asia. In this region, poorly managed landfills allow toxic liquids to drain into underground water sources. If instead, these wastes were used in a biogas plant, water pollution would be reduced. The same argument could be made for the local air quality. Therefore, biogas generation, in addition to producing renewable energy, also improves local water and air quality. The solid end-waste product of the biogas generation process is enriched natural organic matter (digestate), which can be substituted for chemical fertilizers, providing another environmental benefit to biogas. This book is primarily concerned with the production of biogas. From the raw material pre-treatment to the reactor design and operation to the post-treatment system, this book covers all aspects of production. There are many types of biogas reactors, each with their own advantages. Which reactor to select depends on the type and quantity of raw material, land area available and climate, among other factors. This book provides information on selecting and operating a suitable biogas system for interested parties bethey governmental, NGO¿s, private companies or individuals. Biogas contains primarily methane (CH4) and carbon dioxide (CO2). It may also contain small quantities of carbon monoxide (CO), hydrogen sulfide (H2S), moisture and siloxanes. Extracting the methane from all other gases is called biogas upgrading and the output is then referred to as biomethane. These upgrading processes are not the subject of this book as they are already the subject of a previously published book.

This book puts forward the concept of ¿subjective anthropology¿ and outlines a theoretical system that will allow subjective anthropology to qualify as a new academic discipline in its own right. In an effort to respond to the field¿s proper role as the science of humanity, subjective analysis has been introduced into the study of anthropology. The book fills two distinct gaps in our knowledge and understanding of modern man, offering detailed descriptions of personality and of groups, while also advancing the theory of ¿structure and choice.¿ The book formulates seven basic principles of subjective anthropology and divides anthropology into three major branches: subjective anthropology, cultural anthropology, and biological (or physical) anthropology, which can be further divided into sub-branches. The book pursues three key goals: advancing and developing the theoretical system of subjective anthropology, reconstructing the discipline of anthropology, and establishing a Chinese anthropology with Chinese characteristics, Chinese visions, and Chinese styles.

This book provides a broad overview of the theory and practice of creativity and innovation. It is an interdisciplinary study that synthesizes the popular, complex and contemporary discourses on the topic. The approach of the book is centred on praxis, that is, it is grounded strongly in research-based theories, but aims to offer ideas on how to apply creativity and innovation in the everyday context. The authors present an expansive and well-informed perspective on creativity and innovation that transcends any single discipline or specialist area, making the book accessible, readable and memorable. Above all, the reader will be able read the book with a high degree of ease, grasp and retain key and critical concepts of creativity (and the creative process) and innovation (and the innovative process) as well as consider ways of applying them in their everyday lives across all vocations and professional contexts.

Thyroid nodules with benign signs might be subjectively diagnosed as malignant, leading to over treatment, and nodules with malignant signs might be regarded as benign causing insufficient curing. In order to improve the accuracy rate of thyroid nodules, this book analysed ultrasound diagnosis for thyroid nodules in multiple difficult and misdiagnosed cases from thyroid surgeons¿ perspective and closely combined ultrasound imaging with clinical information, including ultrasound images and palpation of thyroid nodules, ultrasound detection video, gross specimen and pathologic diagnosis to interpret the ultrasound images of thyroid nodules, which can be a reference for thyroid surgeons and beginner.This is the first book which has systematically summarized the ultrasound thyroid nodules from the perspective of surgeons, closely combining the imaging and clinical characteristics.Contains abundant clinical cases, and can be used as a teaching book for beginner and an expert-led training course.Help surgeons to better carry out clinical work, making up for the lack of knowledge in anatomy and clinical pathology.Helps surgeons to perform the preoperative ultrasound evaluation, in order to decrease the missed and misdiagnosed nodules.

The book discusses the latest developments and outlines future trends in the fields of microelectronics, electromagnetics and telecommunication. It contains original research works presented at the International Conference on Microelectronics, Electromagnetics and Telecommunication (ICMEET 2022), held in Bheemavaram, West Godavari (Dist), Andhra Pradesh, India during 22 ¿ 23 July 2022. The papers were written by scientists, research scholars and practitioners from leading universities, engineering colleges and R&D institutes from all over the world, and share the latest breakthroughs in and promising solutions to the most important issues facing today¿s society.

The second edition of this book systematically summarizes the latest research findings on high-speed railway track dynamics, made by the author and his research team over the past decade. It explores cutting-edge issues concerning the basic theory of high-speed railways, covering the dynamic theories, models, algorithms and engineering applications of the high-speed train and track coupling system.Presenting original concepts, systematic theories and advanced algorithms, the book places great emphasis on the precision and completeness of its content. The chapters are interrelated yet largely self-contained, allowing readers to either read through the book as a whole or focus on specific topics. It also combines theories with practice to effectively introduce readers to the latest research findings and developments in high-speed railway track dynamics. It offers a valuable resource for researchers, postgraduates and engineers in the fields of civil engineering, transportation, highway and railway engineering.

This highly informative and carefully presented book focuses on the fields of ergonomics/human factors and discusses the future of the community vis-a-vis health problems, productivity, aging, etc. Ergonomic intercession must be seen in light of its effect on productivity because ergonomic solutions will improve productivity as the reduction of environmental stressors, awkward postures and efforts lead to a reduction in task execution time. The book provides promising evidence that the field of ergonomics continues to thrive and develop deeper insights into how work environments, products and systems can be developed to meet needs, demands and limitations of humans and how they can support productivity improvements. Some of the themes covered are anthropometry and workplace design, biomechanics and modelling in ergonomics, cognitive and environmental ergonomics, ergonomic intervention and productivity, ergonomics in transport, mining, agriculture and forestry, health systems, work physiology and sports ergonomics, etc. This book is beneficial to academicians, policymakers and the industry alike.</p>^

Preparatory Considerations.- I / The Structures and the Sphere of Objective Formal Logic.- 1. Formal logic as apophantic analytics.- 2. Formal apophantics, formal mathematics.- 3. Theory of deductive systems and theory of multiplicities.- 4. Focusing on objects and focusing on judgments.- 5. Apophantics, as theory of sense, and truthlogic.- II / From Formal to Transcendental Logic.- 1. Psychologism and the laying of a transcendental foundation for logic.- 2. Initial questions of transcendental-logic: problems concerning fundamental concepts.- 3. The idealizing presuppositions of logic and the constitutive criticism of them.- 4. Evidential criticism of logical principles carried back to evidential criticism of experience.- 5. The subjective grounding of logic as a problem belonging to transcendental philosophy.- 6. Transcendental phenomenology and intentional psychology. The problem of transcendental psychologism.- 7. Objective logic and the phenomenology of reason.- Conclusion.- Appendix I / Syntactical Forms and Syntactical Stuffs; Core-Forms and Core-Stuffs.- § 1. The articulation of predicative judgments.- § 2. Relatedness to subject-matter in judgments.- § 3. Pure forms and pure stuffs.- § 4. Lower and higher forms. Their sense-relation to one another.- § 5. The self-contained functional unity of the self-sufficient apophansis. Division of the combination-forms of wholes into copulatives and conjunctions.- § 6. Transition to the broadest categorial sphere.- a. Universality of the combination-forms that we have distinguished.- b. The distinctions connected with articulation can be made throughout the entire categorial sphere.- c. The amplified concept of the categorial proposition contrasted with the concept of the proposition in the old apophantic analytics.- § 7. Syntactical forms, syntactical stuffs, syntaxes.- § 8. Syntagma and member. Self-sufficient judgments, and likewise judgments in the amplified sense, as syntagmas.- § 9. The "judgment-content" as the syntactical stuff of the judgment qua syntagma.- § 10. Levels of syntactical forming.- § 11. Non-syntactical forms and stuffs - exhibited within the pure syntactical stuffs.- § 12. The core-formation, with core-stuff and core-form.- § 13. Pre-eminence of the substantival category. Substantivation.- § 14. Transition to complications.- § 15. The concept of the "term" in traditional formal logic.- Appendix II / The Phenomenological Constitution of the Judgment. Originally Active Judging and Its Secondary Modifications.- § 1. Active judging, as generating objects themselves, contrasted with its secondary modifications.- § 2. From the general theory of intentionality.- a. Original consciousness and intentional modification. Static intentional explication. Explication of the "meaning" and of the meant "itself." The multiplicity of possible modes of consciousness of the Same.- b. Intentional explication of genesis. The genetic, as well as static, originality of the experiencing manners of givenness. The "primal instituting" of "apperception" with respect to every object-category.- c. The time-form of intentional genesis and the constitution of that form. Retentional modification Sedimentation in the inconspicuous substratum (unconsciousness).- § 3. Non-original manners of givenness of the judgment.- a. The retentional form as the intrinsically first form of "secondary sensuousness". The livingly changing constitution of a many-membered judgment.- b. Passive recollection and its constitutional effect for the judgment as an abiding unity.- c. The emergence of something that comes to mind apperceptionally is analogous to something coming to mind after the fashion of passive recollection.- § 4. The essential possibilities of activating passive manners of givenness.- § 5. The fundamental types of originally generative judging and of any judging whatever.- § 6. Indistinct verbal judging and its function.- § 7. The superiority of retentional and recollectiona

Studies on the Archaeology of the Netherlands Antilles: I.- Studies on the Archaeology of the Netherlands Antilles: II.