Books published by Springer Verlag, Singapore

This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes¿ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

This volume offers detailed information on the behaviour of various water pollutants, and on the principles and concepts of groundwater flow and transport. It will help readers to understand and execute the planning, supervision, and review of solute transport and groundwater modeling projects. The book also discusses the role and fate of elements that have been identified as major contaminants in surface and subsurface waters, and their adverse effects on ecology and human health. The book explores this theme throughout four sections ¿ a. Understanding Soil-Water Systems, b. Fate and Transport of Pollutants, c. Physico-Chemical Treatment of Wastewater and d. Microbial Techniques Used to Decontaminate Soil-Water Systems. Introducing readers to a range of recent advances concerning the fundamentals of subsurface water treatment, it offers a valuable guide for teachers, researchers, policymakers, and undergraduate and graduate students of hydrology, environmental microbiology, biotechnology and the environmental sciences. It also provides field engineers and industrial practitioners with essential support in the effective remediation and management of polluted sites.

This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies.

This book reviews the application of Nanobiotechnology in the development of Nanomedicine, while also discussing the latest trends and challenges in the clinical translation of Nanomedicine. Nanomedicine refers to the application of Nanotechnology to medicine and holds tremendous potential for achieving improved efficiency, bioavailability, dose response, personalized medicine and enhanced safety as compared to conventional medicines.The book first introduces readers to the basic concepts of Nanomedicine, and to technological advances in and applications of Nanotechnology in treatment, diagnosis, monitoring, and drug delivery. In turn, it reviews the current status of multi-functionalization strategies for using Nanoparticles in the targeted delivery of therapeutic agents. The book¿s third and final section focuses on the regulatory and safety challenges posed by Nanomedicine, including industry and regulatory agencies¿ efforts to address them.

The First Edition of the book is a collection of articles, all by the author, on the Indian mathematical genius Srinivasa Ramanujan as well as on some of the greatest mathematicians in history whose life and works have things in common with Ramanujan. It presents a unique comparative study of Ramanujan¿s spectacular discoveries and remarkable life with the monumental contributions of various mathematical luminaries, some of whom, like Ramanujan, overcame great difficulties in life. Also, among the articles are reviews of three important books on Ramanujan¿s mathematics and life. In addition, some aspects of Ramanujan¿s contributions, such as his remarkable formulae for the number pi, his path-breaking work in the theory of partitions, and his fundamental observations on quadratic forms, are discussed. Finally, the book describes various current efforts to ensure that the legacy of Ramanujan will be preserved and continue to thrive in the future.This Second Edition is an expanded version of the first with six more articles by the author. Of note is the inclusion of a detailed review of the movie The Man Who Knew Infinity, a description of the fundamental work of the SASTRA Ramanujan Prize Winners, and an account of the Royal Society Conference to honour Ramanujan¿s legacy on the centenary of his election as FRS.

This volume comprises select papers presented during the Indian Geotechnical Conference 2018. This volume focuses on discussing the many challenges encountered in geoenvironmental engineering. The book covers sustainability aspects related to geotechnical engineering, problematic soils and ground improvement, use of geosynthetics and concepts of soil dynamics. The contents of this book will be useful to researchers and professionals working in geo-environmental engineering and to policy makers interested in understanding geotechnical concerns related to sustainable development.

This volume comprises select papers presented during the Indian Geotechnical Conference 2018. This volume discusses concepts of soil dynamics and studies related to earthquake geotechnical engineering, slope stability, and landslides. The papers presented in this volume analyze failures connected to geotechnical and geological origins to improve professional practice, codes of analysis and design. This volume will prove useful to researchers and practitioners alike.

This book comprehensively reviews the various automated and semi-automated signal and image processing techniques, as well as deep-learning-based image analysis techniques, used in healthcare diagnostics.It highlights a range of data pre-processing methods used in signal processing for effective data mining in remote healthcare, and discusses pre-processing using filter techniques, noise removal, and contrast-enhanced methods for improving image quality.The book discusses the status quo of artificial intelligence in medical applications, as well as its future. Further, it offers a glimpse of feature extraction methods for reducing dimensionality and extracting discriminatory information hidden in biomedical signals. Given its scope, the book is intended for academics, researchers and practitioners interested in the latest real-world technological innovations.

This book gathers a collection of essays that describe recent innovations in food technology including food processing, packaging, food safety, and novel ingredients. By 2050, the world will face the challenge of having to feed an estimated 9 billion people. In order to meet that challenge, innovations in food research are of the utmost importance. The book is divided into four sections, each of which explores an important aspect like food processing, food microbiology, and nutritional security. Written by respected scholars in the field, the respective chapters discuss a range of new and enhanced food materials, as well as processing innovations to extend shelf life and reduce toxic effects. The book also addresses the health potential of various nutraceuticals, bio-absorption of metals and their positive impacts on living systems, as well as methods for reducing food wastage, preventing the loss of nutritive value, and preserving or enhancing palatability.Given its scope, the book will be highly interesting for food scientists, both in academia and the food industry. It will also benefit advanced graduate students and senior researchers.