Books in the Theoretical Biology series

This book helps the reader make use of the mathematical models of biological phenomena starting from the basics of programming and computer simulation. Computer simulations based on a mathematical model enable us to find a novel biological mechanism and predict an unknown biological phenomenon. Mathematical biology could further expand the progress of modern life sciences. Although many biologists are interested in mathematical biology, they do not have experience in mathematics and computer science. An educational course that combines biology, mathematics, and computer science is very rare to date. Published books for mathematical biology usually explain the theories of established mathematical models, but they do not provide a practical explanation for how to solve the differential equations included in the models, or to establish such a model that fits with a phenomenon of interest. MATLAB is an ideal programming platform for the beginners of computer science. This book starts from the very basics about how to write a programming code for MATLAB (or Octave), explains how to solve ordinary and partial differential equations, and how to apply mathematical models to various biological phenomena such as diabetes, infectious diseases, and heartbeats. Some of them are original models, newly developed for this book. Because MATLAB codes are embedded and explained throughout the book, it will be easy to catch up with the text. In the final chapter, the book focuses on the mathematical model of the proneural wave, a phenomenon that guarantees the sequential differentiation of neurons in the brain. This model was published as a paper from the author¿s lab (Sato et al., PNAS 113, E5153, 2016), and was intensively explained in the book chapter ¿Notch Signaling in Embryology and Cancer¿, published by Springer in 2020. This book provides the reader who has a biological background with invaluable opportunities to learn and practice mathematical biology.

This book shows that evolutionary game theory can unravel how mutual cooperation, trust, and credit in a group emerge in organizations and institutions. Some organizations and institutions, such as insurance unions, credit unions, and banks, originated from very simple mutual-aid groups. Members in these early-stage mutual-aid groups help each other, making rules to promote cooperation, and suppressing free riders. Then, they come to ¿trust¿ not only each other but also the group they belong to, itself. The division of labor occurs when the society comes to have diversity and complexity in a larger group, and the division of labor also requires mutual cooperation and trust among different social roles. In a larger group, people cannot directly interact with each other, and the reputation of  unknown people helps other decide who is a trustworthy person. However, if gossip spreads untruths about a reputation, trust and cooperation are destroyed. Therefore, how to suppress untrue gossip is also important for trust and cooperation in a larger group. If trustworthiness and credibility can be established, these groups are successfully sustainable. Some develop and evolve and then mature into larger organizations and institutions. Finally, these organizations and institutions become what they are now. Therefore, not only cooperation but also trust and credit are keys to understanding these organizations and institutions.The evolution of cooperation, a topic of research in evolutionary ecology and evolutionary game theory, can be applied to understanding how to make institutions and organizations sustainable, trustworthy, and credible. It provides us with the idea that evolutionary game theory is a good mathematical tool to analyze trust and credit. This kind of research can be applied to current hot topics such as microfinance and the sustainable use of ecosystems.

This textbook provides an introduction to the mathematical models of population dynamics in mathematical biology. The focus of this book is on the biological meaning/translation of mathematical structures in mathematical models, rather than simply explaining mathematical details and literacies to analyze a model. In some recent usages of the mathematical model simply with computer numerical calculations, the model includes some inappropriate mathematical structure concerning the reasonability of modeling for the biological problem under investigation. For students and researchers who study or use mathematical models, it is important and helpful to understand what mathematical setup could be regarded as reasonable for the model with respect to the relation between the biological factors involved in the assumptions and the mathematical structure of the model.Topics covered in this book are; modeling with geometric progression, density effect in population dynamics, deriving continuous time models from discrete time models, basic modeling for birth-death stochastic processes, continuous time models, modeling interspecific reaction for the continuous time population dynamics model, competition and prey-predator dynamics, modeling for population dynamics with a heterogeneous structure of population, qualitative analysis on the discrete time dynamical system, necessary knowledge about fundamental mathematical theories to understand the dynamical nature of continuous time models. The book includes popular topics in ecology and mathematical biology, as well as classic theoretical topics.By understanding the biological meaning of modeling for simple models, readers will be able to derive a specific mathematical model for a biological problem by reasonable modeling. The contents of this book is made accessible for readers without strong Mathematical background.

This book presents new theoretical perspectives on ecological community dynamics and in so doing casts fresh light on the enduring complexity-stability debate.

This book presents a unique fusion of two different research topics. Although the combination is simple and straightforward, the book describes the emergence of rather intricate behavior, provoking the interest of readers for further developments and applications of related topics.