Clamp Loader of Escherichia Coli Dna Polymerase III

Abstract:

Sliding clamps tether DNA polymerases to DNA to increase the processivity of synthesis. The Escherichia coli ¿ complex loads the ¿ sliding clamp onto DNA in an ATP-dependent reaction in which ATP binding and hydrolysis modulate the affinity of the ¿ complex for ¿ and DNA. This dissertation covers research describing the kinetic mechanism of clamp loading by gamma complex.

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