Delivery of Phytosterol Based Drugs Against Colon Cancer

The delivery of drug molecules in the human system for therapeutic purposes is an imperative truth in clinical research. The recent advancements in the pharmaceutical sciences have shown significant progression in the drug delivery systems. Looking back into the last decades, there is a significant requirement in the pharmaceutical area for more patient compatible and certified effective medicine distribution dosage forms in cancer and other diseases. The drug properties like absorption, solubility, bioavailability and also carrier properties (e.g., retention time at the specific target-site) are the bottleneck for effective drug distribution. The novel medicine distribution dosage is able to manage the drawbacks of the conventional drugs that provide the medication over longer duration and improve medication solubility, maintaining medicine activity, achieving target-specificity and decreasing the possibilities of side-effects etc. The aim of novel medication distribution mechanisms is to deliver the drug molecules to the target locations without medicine depletion by keeping the plasma drug amount for an extended period of time and improving patient compliances. Currently, many researchers across the globe are looking into the development of new reliable targeted drug delivery systems to improve and enhance the efficacy of the treatment by restricting side-effects.

During the year 1909, Paul Ehrlich started the work for the development of targeted delivery of particles by anticipating the medication delivery procedure that would target the affected disease cells directly. Paul Ehrlich recommended that medicine distribution to be a 'miracle bullet'. According to him, target- specific drug delivery is an occasion in which a drug launching provider complex or conjugate would deliver drug molecules solely to the pre-identified cells in a particular predicted manner.

The 'drug targeting' is specified as the ability to instruct the medication molecules, particularly to the sites of activity with small or absence of any type of interaction with the non-required tissues