Protein Folding and Metal Ions

Discussing the role of metal ions in protein folding, this volume provides case examples of protein folding and stability studies in particular systems as well as proteins that comprise different metal ions or cofactors. It reviews those proteins that shuttle metal ions within the cell to a particular target metalloprotein and illustrates how metal binding can be linked to pathological protein conformations in unrelated diseases. The final section addresses the redesign of metal-containing proteins by computational methods, folding simulation studies, and work on model peptides.