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Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

About Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

This book explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies. For clustered studies, the authors provide sample size formulas that account for variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas that account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the authors describe how randomization impacts trial administration, analysis, and sample size requirement.

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  • Language:
  • English
  • ISBN:
  • 9781466556263
  • Binding:
  • Hardback
  • Pages:
  • 260
  • Published:
  • December 9, 2014
  • Dimensions:
  • 157x241x18 mm.
  • Weight:
  • 522 g.
Delivery: 2-3 weeks
Expected delivery: October 19, 2024

Description of Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

This book explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies. For clustered studies, the authors provide sample size formulas that account for variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas that account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the authors describe how randomization impacts trial administration, analysis, and sample size requirement.

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