Books in the Wiley Series on Mass Spectrometry series

Mass spectrometry is a powerful analytical technique used to identify unknown compounds, to quantify known materials, and to elucidate the structural and chemical properties of molecules. Inorganic mass spectrometry focuses on the analysis of metals and elements rather than organic compounds.

Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases.

Resolves points of error and misinterpretation that have plagued the use of mass spectrometry in supramolecular chemistry. Provides a brief introduction to mass spectrometry and supramolecular chemistry in order to orient the audience. Offers supramolecular chemists a detailed introduction to mass spectrometric methodology.

Mass spectrometry (MS) is a crucial method in ensuring the production, quality, and safety of grape, wine, and grape-derivative products. This book concisely presents the applications of mass spectrometry in the analysis of wine, from traditional to more recent developments.

* Mass Spectrometry is a major tool to characterize, identify and detect hundreds of known and unknown drugs.

Provides an overview of the use of mass spectrometry (MS) for the analysis of pesticide residues and their metabolites.

* Comprehensive chromatography represents one of the most powerful tools in the separation of complex mixtures * The book is both broad covering many areas of techniques and applications while still being focused to a specific topic.

The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics.

* Provides a single source for readers interested in the development of analytical methods to measure antibiotic residues in food. * Topics include general issues related to analytical quality control and quality assurance, measurement uncertainty, screening and confirmatory methods.

Ion scattering spectrometry, a powerful analytical tool used to determine the structure and composition of a substance, addresses critical problems in semiconductors, thin film growth, coatings, computer chips, magnetic storage devices, bioreactive surfaces, catalytic surfaces, and electrochemical surfaces (including the large battery industry).

This book describes the importance of the emerging technique Cluster Secondary Ion Mass Spectrometry (SIMS), which is used for the analysis of a range of solid materials, including everything from organic and polymeric materials, to cells and semiconductors.

With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists.

* Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation* Discussion of the chemistry behind each modification, along with key methods and references* Contributions from some of the leading researchers in the field* A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research

Provides a single-source reference for readers interested in the development of analytical methods for analyzing non-antimicrobial veterinary drug residues in food Antibiotics are used in a variety of production industries around the world. Some of the industries include dairy, livestock, poultry, and honey production. They are used in animals to promote growth and prevent disease. However the frequent use of antibiotics can cause residues to be found in products of animal origin, such as meat and milk. The presence of excess residues above the allowable maximums is illegal and can cause health problems including allergic reactions and carcinogenicity. Chemical Analysis of Non-antimicrobial Veterinary Drug Residues in Food provides a single-source reference for readers interested in developing analytical methods for analyzing non-antimicrobial veterinary drug residues in food. To ensure the safety of the food supply and to facilitate international trade, government agencies and international bodies establish standards, guidelines, and regulations that food producers and trade partners need to meet, respect, and follow. A primary goal of national and international regulatory frameworks for the use of veterinary drugs is to ensure that authorized products are used in a manner that will not lead to non-compliance residues. However, analytical methods are required to rapidly and accurately detect, quantify, and confirm antibiotic residues in food to verify that regulatory standards have been met and to remove foods that do not comply with these standards from the marketplace. This book covers key aspects of the analysis for these residues combining disciplines including sample preparation, the application of high resolution mass spectrometry in the development of multi-residue, multi-class analytical methods, regulatory standards setting, method validation, and quality assurance and control issues specifically related to multi-residue methods (MRMs). Chemical Analysis of Non-antimicrobial Veterinary Drug Residues in Food features: A comprehensive set of information in the area of consumer food safety and international trade General issues related to measurement uncertainty, screening, and confirmatory methods Techniques ranging from nanotechnology and aptamer based assays covering current and potential applications for non-antimicrobial veterinary drugs Guidance for analysis of banned drugs including natural and synthetic steroids, Resorcylic acid lactones, and Beta-agonists This book can be used by analysts, scientists, managers and/or laboratories that conduct chemical analysis of antibiotic residues in food, drinking water, or even biological and environmental samples. It can also serve as a reference book for students, at universities and colleges, who take subjects related to chemical residue analysis. Jack F. Kay works in the UK Department for Environment, Food and Rural Affairs. He has actively participated in the Codex Committee on Residues of Veterinary Drugs in Food for more than ten years. James D. MacNeil retired as head of the Centre for Veterinary Drug Residues of the Canadian Food Inspection Agency in 2007. He is the former scientific editor for "Drugs, Cosmetics, and Forensics" of the Journal of AOAC International. Jian Wang is currently a research scientist leading a research and development unit for the Canadian Food Inspection Agency in Calgary, Alberta. He has written over thirty publications for various journals and books.

A guide for scientists, pediatricians and students involved in metabolic studies in pediatric research Addresses the availability of modern analytical techniques and how to apply these techniques in metabolic studies Covers the whole range of available mass spectrometric techniques used for metabolic studies including Stable Isotope Methodology Presents the relevance of mass spectrometry and stable isotope methodology in pediatric research covering applications in Nutrition, Obesity, Metabolic Disorders, and Kidney Disorders Focuses on the interactions between nutrients and the endogenous metabolism within the body and how these factors affect the health of a growing infant

Protein carbonylation has attracted the interest of a great number of laboratories since the pioneering studies at the Earl Stadtman s lab at NIH started in early 1980s.

Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can not only serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry--from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. Provides a description of mass spectrometry basics, applications and perspectives of the technique Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation Includes a list of key terms, and test questions, for easier and faster understanding of the material Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.

One of the primary goals of current proteomic research is the description of the composition, dynamics, and connections of the multi-protein "modules" and "machineries" that perform a wide range of biological functions in the cell. This is one of the first books to focus on the dynamic aspect of proteomes.

The last few years have seen an unprecedented drive toward the application of proteomics to resolving challenging biomedical and biochemical tasks. Separation techniques combined with modern mass spectrometry are playing a central role in this drive. This book discusses the increasingly important role of mass spectrometry in proteomic research, and emphasizes recent advances in the existing technology and describes the advantages and pitfalls as well.* Provides a scientifically valid method for analyzing the approximatey 500,000 proteins that are encoded in the human genome* Explains the hows and whys of using mass spectrometry in proteomic analysis* Brings together the latest approaches combining separation techniques and mass spectrometry and their application in proteome analysis* Comments on future challenges and how they may be addressed* Includes sections on troubleshooting

With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices.

Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to explore the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed. Integration of Omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting. Describes a range of state of the art omics analytical platforms Covers all aspects of the systems biology approach-from sample preparation to data integration and bioinformatics analysis Contains specific examples of omics methods applied in the investigation of human diseases (Chronic Kidney Disease, Bladder Cancer) Integration of Omics Approaches and Systems Biology for Clinical Applications will appeal to a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, and bioinformaticians working on the different molecular platforms. It is also an excellent text for students interested in these fields.

Covers the area of lipidomics from fundamentals and theory to applications* Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics* Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids* Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation* Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes

With its detailed and systematic coverage of the current state of biophysical mass spectrometry (MS), here is one of the first systematic presentations of the full experimental array of MS-based techniques used in biophysics, covering both fundamental and practical issues.

Provides comprehensive coverage of the interpretation of LC-MS-MS mass spectra of 1300 drugs and pesticides* Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes* This is the reference book for the interpretation of MS-MS mass spectra of small organic molecules* Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others* Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups* Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns

In the arena of new drug development, the rate of sample generation far exceeds the rate of sample analysis. LC/MS is an analytical tool that helps the researcher select the most promising sample for scrutiny, accelerating the discovery of new drugs. This book is the first to describe in detail the procedures and benefits of LC/MS applications.

This volume describes the complete process of analyzing protein sequences by mass spectrometry including sample preparation, analysis, and data interpretation at a practical level. It provides sufficient experimental detail to carry out the experiments and consistently achieve good results.

Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis.

Principles of Mass Spectrometry Applied to Biomolecules teaches readers how to use what they know about Mass Spectrometry's advantages and limitations to develop novel ways of using the technique for the analysis of proteins and other biomolecules.

A concise and authoritative overview of mass spectrometry instrumentation, techniques, and applications in a very readable, user-friendly format filled with chapter summaries, exercises and answers, and references to useful outside resources. * Includes numerous exercises in every chapter, with the answers at the back of the book.